DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmt and NMT1

DIOPT Version :9

Sequence 1:	NP_523969.1	Gene:	Nmt / 38909	FlyBaseID:	FBgn0020392	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_066565.1	Gene:	NMT1 / 4836	HGNCID:	7857	Length:	496	Species:	Homo sapiens

Alignment Length:	433	Identity:	265/433 - (61%)
Similarity:	319/433 - (73%)	Gaps:	14/433 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EDAEQPDGAKNEASVSANASKQALLQAVSDAM---------ASTRQMAKK--FAFWSTQPVTKLD 103
            |...:.|.|::: .|..|:.....:|.:..|:         |.|.:.|.|  :.||.||||.||.
Human    66 EKGSETDSAQDQ-PVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLG 129

  Fly   104 EQVTTNECIEPNKEISEIRALPYTLPGGFKWVTLDLNDANDLKELYTLLNENYVEDDDAMFRFDY 168
            |.|.|:..:||:|:  .||..|||||.||.|..|||.|...|||||||||||||||||.||||||
Human   130 EVVNTHGPVEPDKD--NIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDY 192

  Fly   169 QPEFLKWSLQPPGWKRDWHVGVRVEKSGKLVGFISAIPSKLKSYDKVLKVVDINFLCVHKKLRSK 233
            .||||.|:|:||||...||.||||..|.||||||||||:.:..||...|:|:|||||||||||||
Human   193 SPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSK 257

  Fly   234 RVAPVLIREITRRVNLTGIFQAAYTAGVVLPTPVATCRYWHRSLNPKKLVDVRFSHLARNMTMQR 298
            ||||||||||||||:|.|||||.||||||||.||.|||||||||||:||::|:||||:|||||||
Human   258 RVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQR 322

  Fly   299 TMKLYKLPDQPKTKGYRRITAKDMDKAHKLLEDYLKRFQLSPVFSKEEFRHWFTPKEGIIDCFVV 363
            |||||:||:.|||.|.|.:..||:...|:||..|||:|.|:||.|:||..|||.|:|.|||.|||
Human   323 TMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVV 387

  Fly   364 ADEKGNITDLTSYYCLPSSVMHHPVHKTVRAAYSFYNVSTKTPWLDLMNDALISARNVQMDVYNA 428
            .:..|.:||..|:|.|||::|:||.||:::||||||||.|:||.||||:|||:.|:....||:||
Human   388 ENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNA 452

  Fly   429 LDLMENKKYFAPLKFGAGDGNLQYYLYNWRCPSMQPEEIALIL 471
            |||||||.:...||||.||||||||||||:||||..|::.|:|
Human   453 LDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmt	NP_523969.1	NMT	112..268	CDD:279562	113/155 (73%)
Nmt	NP_523969.1	NMT_C	284..459	CDD:280893	109/174 (63%)
NMT1	NP_066565.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82		4/16 (25%)
		NMT1	86..484	CDD:227423	253/399 (63%)
		Myristoyl-CoA binding. /evidence=ECO:0000269\|PubMed:25255805, ECO:0000269\|Ref.17	118..120		0/1 (0%)
		Myristoyl-CoA binding. /evidence=ECO:0000269\|PubMed:25255805, ECO:0000269\|Ref.17	248..250		1/1 (100%)
		Myristoyl-CoA binding. /evidence=ECO:0000269\|PubMed:25255805, ECO:0000269\|Ref.17	256..260		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147522
Domainoid	1	1.000	247	1.000	Domainoid score	I2156
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69027
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1182
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53825
OrthoDB	1	1.010	-	-		D1025421at2759
OrthoFinder	1	1.000	-	-		FOG0002110
OrthoInspector	1	1.000	-	-		otm40585
orthoMCL	1	0.900	-	-		OOG6_101234
Panther	1	1.100	-	-	LDO	PTHR11377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R818
SonicParanoid	1	1.000	-	-		X1227
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940