DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmt and nmt1a

DIOPT Version :9

Sequence 1:	NP_523969.1	Gene:	Nmt / 38909	FlyBaseID:	FBgn0020392	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_001018316.1	Gene:	nmt1a / 323956	ZFINID:	ZDB-GENE-050522-477	Length:	487	Species:	Danio rerio

Alignment Length:	506	Identity:	274/506 - (54%)
Similarity:	335/506 - (66%)	Gaps:	61/506 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NENAEDLSGQELKQKAKEVADASEAMLEKVVAGLNIQDTASTNAAGNEDAEQPDGAKNEASVSAN 67
            ||.|      .|.:|.:||.                :|....:...||:....||.|.:......
Zfish     5 NETA------PLPEKEEEVE----------------EDHGHCSNCENEEHHSDDGEKGDTGAKKK 47

  Fly    68 ASKQA--------------------------LLQAVSDAM---------ASTRQMA--KKFAFWS 95
            ..||.                          .||.:..|:         |.|.:.|  :.:.||.
Zfish    48 KKKQKKKNKDKSGAKDAAQDPLAKVNSLPADKLQEIQKAIELFSVGQGPAKTMEEATRRSYQFWD 112

  Fly    96 TQPVTKLDEQVTTNECIEPNKEISEIRALPYTLPGGFKWVTLDLNDANDLKELYTLLNENYVEDD 160
            ||||.||.|.||::.||||:|:  .||..||:||.||.|.||||.:|..||||||||||||||||
Zfish   113 TQPVPKLGETVTSHGCIEPDKD--NIREEPYSLPQGFTWDTLDLGNAAVLKELYTLLNENYVEDD 175

  Fly   161 DAMFRFDYQPEFLKWSLQPPGWKRDWHVGVRVEKSGKLVGFISAIPSKLKSYDKVLKVVDINFLC 225
            |.||||||.||||.|:|:||||...||.||||..:.||||||||||:.::.||...|:|:|||||
Zfish   176 DNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVNSNQKLVGFISAIPANIRIYDIEKKMVEINFLC 240

  Fly   226 VHKKLRSKRVAPVLIREITRRVNLTGIFQAAYTAGVVLPTPVATCRYWHRSLNPKKLVDVRFSHL 290
            ||||||:|||||||||||||||||.|||||.||||||||.||.|||||||||||:||::|:||||
Zfish   241 VHKKLRAKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHL 305

  Fly   291 ARNMTMQRTMKLYKLPDQPKTKGYRRITAKDMDKAHKLLEDYLKRFQLSPVFSKEEFRHWFTPKE 355
            :||||||||||||:||:.|||.|.|.:|.||:...|:||::||.:|.|.||.|.||.:||..|:|
Zfish   306 SRNMTMQRTMKLYRLPEAPKTAGLRPMTIKDIPLVHRLLKEYLNQFNLVPVMSPEEVQHWLLPQE 370

  Fly   356 GIIDCFVVADEKGNITDLTSYYCLPSSVMHHPVHKTVRAAYSFYNVSTKTPWLDLMNDALISARN 420
            .|||.:||....|.:||:.|:|.|||::|:||||::::||||||||.|.||.:|||.||||.|::
Zfish   371 NIIDTYVVETTDGKVTDILSFYTLPSTIMNHPVHRSLKAAYSFYNVHTTTPLVDLMGDALILAKS 435

  Fly   421 VQMDVYNALDLMENKKYFAPLKFGAGDGNLQYYLYNWRCPSMQPEEIALIL 471
            ...||:|||||||||.:...||||.||||||||||||:||||..|::.|:|
Zfish   436 KGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGSEKVGLVL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmt	NP_523969.1	NMT	112..268	CDD:279562	113/155 (73%)
Nmt	NP_523969.1	NMT_C	284..459	CDD:280893	107/174 (61%)
nmt1a	NP_001018316.1	NMT1	77..475	CDD:227423	252/399 (63%)
		NMT	129..282	CDD:279562	112/154 (73%)
		NMT_C	299..474	CDD:280893	107/174 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581260
Domainoid	1	1.000	245	1.000	Domainoid score	I2146
eggNOG	1	0.900	-	-		E1_COG5092
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69027
Inparanoid	1	1.050	539	1.000	Inparanoid score	I1148
OMA	1	1.010	-	-		QHG53825
OrthoDB	1	1.010	-	-		D1025421at2759
OrthoFinder	1	1.000	-	-		FOG0002110
OrthoInspector	1	1.000	-	-		otm26452
orthoMCL	1	0.900	-	-		OOG6_101234
Panther	1	1.100	-	-	LDO	PTHR11377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R818
SonicParanoid	1	1.000	-	-		X1227
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800