DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmt and Nmt2

DIOPT Version :9

Sequence 1:	NP_523969.1	Gene:	Nmt / 38909	FlyBaseID:	FBgn0020392	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_997473.1	Gene:	Nmt2 / 291318	RGDID:	1303175	Length:	529	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	275/511 - (53%)
Similarity:	343/511 - (67%)	Gaps:	58/511 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ENAEDLSGQEL-------KQKAKEVADASEAMLEKVVAGLNIQDTASTNAAGNEDAEQPDGAKNE 61
            |:|:...|::|       |||.|:         ||..:|    .|.|.:|:.:::.:....:|:.
  Rat    33 EHAKGSPGRDLGAKKKKKKQKRKK---------EKPNSG----GTKSDSASDSQEIKIQQSSKHN 84

  Fly    62 A---SVSANASK-----------------------------QALLQAVSDAMASTRQM----AKK 90
            |   .:||.|:.                             |..::.:|......|.:    .::
  Rat    85 AIWQQISAGAAMGGDTMEGEWIDLRMYHKNPTIPIQKLQDIQRAMELLSACQGPARNIDEATKRR 149

  Fly    91 FAFWSTQPVTKLDEQVTTNECIEPNKEISEIRALPYTLPGGFKWVTLDLNDANDLKELYTLLNEN 155
            :.||.||||.||:|.:|::..|||:|:  .||..||:||.||.|.||||::|..|||||||||||
  Rat   150 YQFWDTQPVPKLNEVITSHGAIEPDKD--NIRQEPYSLPQGFMWDTLDLSNAEVLKELYTLLNEN 212

  Fly   156 YVEDDDAMFRFDYQPEFLKWSLQPPGWKRDWHVGVRVEKSGKLVGFISAIPSKLKSYDKVLKVVD 220
            ||||||.||||||.||||.|:|:||||...||.||||..:.||.|||||||:.::.||.|.::|:
  Rat   213 YVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLEGFISAIPANIRIYDSVKRMVE 277

  Fly   221 INFLCVHKKLRSKRVAPVLIREITRRVNLTGIFQAAYTAGVVLPTPVATCRYWHRSLNPKKLVDV 285
            |||||||||||||||||||||||||||||.|||||.||||||||.||||||||||||||:|||:|
  Rat   278 INFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEV 342

  Fly   286 RFSHLARNMTMQRTMKLYKLPDQPKTKGYRRITAKDMDKAHKLLEDYLKRFQLSPVFSKEEFRHW 350
            :||||:||||:|||||||:|||..||.|.|.:..||:....:|:..|||:|.|:||...||..||
  Rat   343 KFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIRAVRELINVYLKQFHLAPVMGDEEVAHW 407

  Fly   351 FTPKEGIIDCFVVADEKGNITDLTSYYCLPSSVMHHPVHKTVRAAYSFYNVSTKTPWLDLMNDAL 415
            |.|:|.|||.|||....|.:||..|:|.|||:|||||.||:::|||||||:.|:||.||||||||
  Rat   408 FLPREHIIDTFVVESPSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMNDAL 472

  Fly   416 ISARNVQMDVYNALDLMENKKYFAPLKFGAGDGNLQYYLYNWRCPSMQPEEIALIL 471
            |.|:....||:|||||||||.:...||||.|||||||||||||||....|::.|:|
  Rat   473 IIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmt	NP_523969.1	NMT	112..268	CDD:279562	113/155 (73%)
Nmt	NP_523969.1	NMT_C	284..459	CDD:280893	108/174 (62%)
Nmt2	NP_997473.1	NMT	171..325	CDD:279562	113/155 (73%)
Nmt2	NP_997473.1	NMT_C	341..516	CDD:280893	108/174 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341321
Domainoid	1	1.000	246	1.000	Domainoid score	I2104
eggNOG	1	0.900	-	-		E1_COG5092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1157
OMA	1	1.010	-	-		QHG53825
OrthoDB	1	1.010	-	-		D1025421at2759
OrthoFinder	1	1.000	-	-		FOG0002110
OrthoInspector	1	1.000	-	-		otm44726
orthoMCL	1	0.900	-	-		OOG6_101234
Panther	1	1.100	-	-	O	PTHR11377
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1227
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810