DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmt and Nmt2

DIOPT Version :9

Sequence 1:	NP_523969.1	Gene:	Nmt / 38909	FlyBaseID:	FBgn0020392	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_032734.1	Gene:	Nmt2 / 18108	MGIID:	1202298	Length:	529	Species:	Mus musculus

Alignment Length:	511	Identity:	275/511 - (53%)
Similarity:	343/511 - (67%)	Gaps:	58/511 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ENAEDLSGQEL-------KQKAKEVADASEAMLEKVVAGLNIQDTASTNAAGNEDAEQPDGAKNE 61
            |:|:...|.:|       |||.|:         ||..:|    .|.|.:|:.:::.:....:|:.
Mouse    33 EHAKGSPGGDLGAKKKKKKQKRKK---------EKPNSG----GTKSDSASDSQEIKIQQSSKHN 84

  Fly    62 A---SVSANASK-----------------------------QALLQAVSDAMASTRQM----AKK 90
            |   .:||.|:.                             |..::.:|......|.:    .::
Mouse    85 AIWQQISAGAAMGGDTMEGEWIDLRMYHKNPTIPIQKLQDIQRAMELLSACQGPARNIDEATKRR 149

  Fly    91 FAFWSTQPVTKLDEQVTTNECIEPNKEISEIRALPYTLPGGFKWVTLDLNDANDLKELYTLLNEN 155
            :.||.||||.||:|.:|::..|||:|:  .||..||:||.||.|.||||::|..|||||||||||
Mouse   150 YQFWDTQPVPKLNEVITSHGAIEPDKD--NIRQEPYSLPQGFMWDTLDLSNAEVLKELYTLLNEN 212

  Fly   156 YVEDDDAMFRFDYQPEFLKWSLQPPGWKRDWHVGVRVEKSGKLVGFISAIPSKLKSYDKVLKVVD 220
            ||||||.||||||.||||.|:|:||||...||.||||..:.||||||||||:.::.||.|.::|:
Mouse   213 YVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKRMVE 277

  Fly   221 INFLCVHKKLRSKRVAPVLIREITRRVNLTGIFQAAYTAGVVLPTPVATCRYWHRSLNPKKLVDV 285
            |||||||||||||||||||||||||||||.|||||.||||||||.||||||||||||||:|||:|
Mouse   278 INFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEV 342

  Fly   286 RFSHLARNMTMQRTMKLYKLPDQPKTKGYRRITAKDMDKAHKLLEDYLKRFQLSPVFSKEEFRHW 350
            :||||:||||:|||||||:|||..||.|.|.:..||:....:|:..|||:|.|:||....|..||
Mouse   343 KFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKAVRELINIYLKQFHLAPVMDDAEVAHW 407

  Fly   351 FTPKEGIIDCFVVADEKGNITDLTSYYCLPSSVMHHPVHKTVRAAYSFYNVSTKTPWLDLMNDAL 415
            |.|:|.|||.|||.:..|.:||..|:|.|||:|||||.||:::|||||||:.|:||.||||||||
Mouse   408 FLPREHIIDTFVVENPSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMNDAL 472

  Fly   416 ISARNVQMDVYNALDLMENKKYFAPLKFGAGDGNLQYYLYNWRCPSMQPEEIALIL 471
            |.|:....||:|||||||||.:...||||.|||||||||||||||....|::.|:|
Mouse   473 IIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmt	NP_523969.1	NMT	112..268	CDD:279562	114/155 (74%)
Nmt	NP_523969.1	NMT_C	284..459	CDD:280893	107/174 (61%)
Nmt2	NP_032734.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82		14/61 (23%)
		Myristoyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:P30419	151..153		0/1 (0%)
		NMT	171..325	CDD:279562	114/155 (74%)
		Myristoyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:P30419	281..283		1/1 (100%)
		Myristoyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:P30419	289..293		3/3 (100%)
		NMT_C	341..516	CDD:280893	107/174 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837601
Domainoid	1	1.000	246	1.000	Domainoid score	I2167
eggNOG	1	0.900	-	-		E1_COG5092
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1188
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53825
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002110
OrthoInspector	1	1.000	-	-		otm42660
orthoMCL	1	0.900	-	-		OOG6_101234
Panther	1	1.100	-	-	O	PTHR11377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R818
SonicParanoid	1	1.000	-	-		X1227
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790