DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmt and Nmt1

DIOPT Version :9

Sequence 1:	NP_523969.1	Gene:	Nmt / 38909	FlyBaseID:	FBgn0020392	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_032733.1	Gene:	Nmt1 / 18107	MGIID:	102579	Length:	496	Species:	Mus musculus

Alignment Length:	469	Identity:	270/469 - (57%)
Similarity:	331/469 - (70%)	Gaps:	25/469 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AEDLSGQELKQKAKEVADASEAMLEKVVAGLNIQDTASTNAAGNEDAEQPDGAKNEASVSANASK 70
            |.|...::.|:|.|          :|...|.:::.|          .:||....:..:......:
Mouse    49 ANDTGAKKKKKKQK----------KKKEKGSDMEST----------QDQPVKMTSLPAERIQEIQ 93

  Fly    71 QAL-LQAVSDAMASTRQMAKK--FAFWSTQPVTKLDEQVTTNECIEPNKEISEIRALPYTLPGGF 132
            :|: |.:|....|.|.:.|.|  :.||.||||.||.|.|.|:..:||:|:  .||..|||||.||
Mouse    94 KAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKD--NIRQEPYTLPQGF 156

  Fly   133 KWVTLDLNDANDLKELYTLLNENYVEDDDAMFRFDYQPEFLKWSLQPPGWKRDWHVGVRVEKSGK 197
            .|..|||.|...|||||||||||||||||.||||||.||||.|:|:||||...||.||||..|.|
Mouse   157 TWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRK 221

  Fly   198 LVGFISAIPSKLKSYDKVLKVVDINFLCVHKKLRSKRVAPVLIREITRRVNLTGIFQAAYTAGVV 262
            |||||||||:.:..||...|:|:|||||||||||||||||||||||||||:|.|||||.||||||
Mouse   222 LVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVV 286

  Fly   263 LPTPVATCRYWHRSLNPKKLVDVRFSHLARNMTMQRTMKLYKLPDQPKTKGYRRITAKDMDKAHK 327
            ||.||.|||||||||||:||::|:||||:||||||||||||:||:.|||.|.|.:..||:...|:
Mouse   287 LPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMEKKDIPVVHQ 351

  Fly   328 LLEDYLKRFQLSPVFSKEEFRHWFTPKEGIIDCFVVADEKGNITDLTSYYCLPSSVMHHPVHKTV 392
            ||..|||:|.|:||.::||..|||.|:|.|||.|||.:..|.:||..|:|.|||::|:||.||::
Mouse   352 LLSRYLKQFHLTPVMNQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSL 416

  Fly   393 RAAYSFYNVSTKTPWLDLMNDALISARNVQMDVYNALDLMENKKYFAPLKFGAGDGNLQYYLYNW 457
            :||||||||.|:||.||||:|||:.|:....||:|||||||||.:...||||.||||||||||||
Mouse   417 KAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNW 481

  Fly   458 RCPSMQPEEIALIL 471
            :||||..|::.|:|
Mouse   482 KCPSMGAEKVGLVL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmt	NP_523969.1	NMT	112..268	CDD:279562	113/155 (73%)
Nmt	NP_523969.1	NMT_C	284..459	CDD:280893	108/174 (62%)
Nmt1	NP_032733.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82		10/52 (19%)
		NMT1	86..484	CDD:227423	253/399 (63%)
		Myristoyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:P30419	118..120		0/1 (0%)
		Myristoyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:P30419	248..250		1/1 (100%)
		Myristoyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:P30419	256..260		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837600
Domainoid	1	1.000	246	1.000	Domainoid score	I2167
eggNOG	1	0.900	-	-		E1_COG5092
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69027
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1188
Isobase	1	0.950	-	0	Normalized mean entropy	S743
OMA	1	1.010	-	-		QHG53825
OrthoDB	1	1.010	-	-		D1025421at2759
OrthoFinder	1	1.000	-	-		FOG0002110
OrthoInspector	1	1.000	-	-		otm42660
orthoMCL	1	0.900	-	-		OOG6_101234
Panther	1	1.100	-	-	LDO	PTHR11377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R818
SonicParanoid	1	1.000	-	-		X1227
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750