Protein Alignment mus301 and polA

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_418300.1
• Gene: polA / 948356
• ECOCYCID: EG10746
• Length: 928
• Species: Escherichia coli
• Alignment Length: 1079
• Identity: 191/1079 - (17%)
• Similarity: 342/1079 - (31%)
• Gaps: 418/1079 - (38%)

  Fly    85 FADTSFPSAQSVPPNSASKPDEASAPTDKHQIDLADEENADKLFKKINLNDLSIAEMEDIFHGAD 149
            |.|..|...:|..|   ..||:..|     ||     |....:.|.:.|..|:::.:|     ||
E. coli    69 FRDELFEHYKSHRP---PMPDDLRA-----QI-----EPLHAMVKAMGLPLLAVSGVE-----AD 115

  Fly   150 DFSDPMVQNTQLFLDAMTFKKP---KTPEKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCEELKN 211
            |....:.:      :|....:|   .|.:|.:|.|...:::.|  :.:...:.|.     ||:.|
E. coli   116 DVIGTLAR------EAEKAGRPVLISTGDKDMAQLVTPNITLI--NTMTNTILGP-----EEVVN 167

  Fly   212 QSLLDPVNWETQAFADF----EKNNQDIDKFPSKGEFYGLPDKVKKMILEH-KGINSLYEWQDEC 271
            :..:.|     :...||    ..::.:|...|..||      |..:.:|:. .|:::||...::
E. coli   168 KYGVPP-----ELIIDFLALMGDSSDNIPGVPGVGE------KTAQALLQGLGGLDTLYAEPEK- 220

  Fly   272 LNLPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILPYV--SIVQEKVSAMSPFAI 334
                        |..|...|.||:.|::...:|:......:..|...|  .:..|::....|.|.
E. coli   221 ------------IAGLSFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELELTCEQLEVQQPAAE 273

  Fly   335 DLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIEKGAVLM-DSLIDVQRPHEIGLVVVDE------ 392
            :|..:.::|           ..||   :.|.:|.|..|. .......:|.|..  |.||
E. coli   274 ELLGLFKKY-----------EFKR---WTADVEAGKWLQAKGAKPAAKPQETS--VADEAPEVTA 322

  Fly   393 --------LHLIGEKGRGATLEAFLTKV----MFL---------NANIQIVGMSATI-----GNL 431
                    :.::.|:    ||:|::.|:    :|.         |.:..:||:|..|     ..:
E. coli   323 TVISYDNYVTILDEE----TLKAWIAKLEKAPVFAFDTETDSLDNISANLVGLSFAIEPGVAAYI 383

  Fly   432 SEISSFLNADVYTRGFRPVEL-------KEYIKCGPDLLE----INSAGQTLEEIFVPSRSVEYN 485
            .....:|:|.......|.:||       ::.:|.|.:|..    :.:.|..|..|...:....|.
E. coli   384 PVAHDYLDAPDQISRERALELLKPLLEDEKALKVGQNLKYDRGILANYGIELRGIAFDTMLESYI 448

  Fly   486 YSEAVKRADPDHLAGLISECAPEHCCLVFCPSRKNCENVA------LLLSRI------------- 531
            .:....|.|.|.||    |...:|..:.|       |.:|      |..::|
E. coli   449 LNSVAGRHDMDSLA----ERWLKHKTITF-------EEIAGKGKNQLTFNQIALEEAGRYAAEDA 502

  Fly   532 -------------VPKHKFFEHRRSEKLDLMDALDKMCGILSPVLAKTLPYG------IAYHHS- 576
                         :.|||       ..|::.:.::..   |.|||::....|      :.::||
E. coli   503 DVTLQLHLKMWPDLQKHK-------GPLNVFENIEMP---LVPVLSRIERNGVKIDPKVLHNHSE 557

  Fly   577 ----GLTTDERKYIETAYRFGVVTVICCTSTLAA------GVNLPAKRVIIRAPYVGQEFLT--- 628
                .|...|:|..|.|   |....:..|..|..      |:. |.|:....||...:|.|.
E. coli   558 ELTLRLAELEKKAHEIA---GEEFNLSSTKQLQTILFEKQGIK-PLKKTPGGAPSTSEEVLEELA 618

  Fly   629 --------------LCK-----------------------YKQMVGRAGRAGLGEAGESILIAQS 656
                          |.|                       |.|.|...||....:.....:..::
E. coli   619 LDYPLPKVILEYRGLAKLKSTYTDKLPLMINPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRN 683

  Fly   657 KDNLLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLE 721
            ::...:.|...:|.|..:.|.|
E. coli   684 EEGRRIRQAFIAPEDYVIVSAD------------------------------------------- 705

  Fly   722 VAVNEIVLRILREMFKNKVLQLAEPQAKS--KINSSDI-------ITSQDVSQANRPAGDRRLLI 777
              .::|.|||:..:.::|.|..|..:.|.  :..::::       :||:....|.  |.:..|:.
E. coli   706 --YSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLETVTSEQRRSAK--AINFGLIY 766

  Fly   778 GQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLILTNYLHLLYLVVCFNSNERGDELFP 842
            |.|.                 :..|..::...|:||:      |:.|.:            |.:|
E. coli   767 GMSA-----------------FGLARQLNIPRKEAQK------YMDLYF------------ERYP 796

  Fly   843 ADASILFGVYTSLPLDSQAMFKQLGFTEAHAARLFKTQSVQGPLSLQLNRLYKVLILADILNLLP 907
                   ||...:. .::|..|:.|:.|                :|...|||
E. coli   797 -------GVLEYME-RTRAQAKEQGYVE----------------TLDGRRLY------------- 824

  Fly   908 IPSVASKYNVER-------------GTLQHLISQSTAAASA-----------IVRLCEELEEFWC 948
            :|.:.|.....|             ||...:|.::..|..|           |:::.:||
E. coli   825 LPDIKSSNGARRAAAERAAINAPMQGTAADIIKRAMIAVDAWLQAEQPRVRMIMQVHDEL----- 884

  Fly   949 YKPLFERILHK-------------MDRCGTFELEPLMEL 974
               :||  :||             |:.|...::..|:|:
E. coli   885 ---VFE--VHKDDVDAVAKQIHQLMENCTRLDVPLLVEV 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	43/237 (18%)
		BRR2	255..828	CDD:440817	123/717 (17%)
polA	NP_418300.1	PRK05755	6..928	CDD:235591	191/1079 (18%)