Protein Alignment mus301 and SLH1

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_011787.4
• Gene: SLH1 / 853187
• SGDID: S000003503
• Length: 1967
• Species: Saccharomyces cerevisiae
• Alignment Length: 1179
• Identity: 243/1179 - (20%)
• Similarity: 431/1179 - (36%)
• Gaps: 315/1179 - (26%)

  Fly    15 LSEESTSESHAKRQCTENLFWPEGEDDDSFFSNAHLEDLLDGRKEELFGTQATTSTNKMTQS--- 76
            ||:||     .:.|....|..|:|:      :|..|:..:.  :..:|.:..::.:|.:.|:
Yeast   854 LSDES-----VECQIGSQLDTPQGK------ANVLLQAYIS--QTRIFDSALSSDSNYVAQNSVR 905

  Fly    77 --------GSDDGLGLFADTSFPSAQSVP---------------PNSASKPDEASAPTDKHQIDL 118
                    |.:...|.|::......:|:.               |.:..:....:.|:.:|.::|
Yeast   906 ICRALFLIGVNRRWGKFSNVMLNICKSIEKRLWAFDHPLCQFDLPENIIRRIRDTKPSMEHLLEL 970

  Fly   119 -ADE--------ENADKLFK------KINLNDLSIAEMEDI------FH---GADDFSDPMVQNT 159
             |||        :...:|:|      |||:.    ||:..|      .|   |.|...|..:...
Yeast   971 EADELGELVHNKKAGSRLYKILSRFPKINIE----AEIFPITTNVMRIHIALGPDFVWDSRIHGD 1031

  Fly   160 QLFLDAMTFKKPKTP----EK---------------LLAPLKDDSMSFISKSVIEGLVQGTQYVT 205
            ..|......:..|:.    ||               .:.||.|.    :...|:..:|..| ::.
Yeast  1032 AQFFWVFVEESDKSQILHFEKFILNRRQLNNQHEMDFMIPLSDP----LPPQVVVKVVSDT-WIG 1091

  Fly   206 CEE---LKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKGEFYGLPDKVKKM------ILEHKGI 261
            ||.   :..|.|:.|.| ||                        |..|:.|:      .|::..|
Yeast  1092 CESTHAISFQHLIRPFN-ET------------------------LQTKLLKLRPLPTSALQNPLI 1131

  Fly   262 NSLYEWQ-----DECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLREL-LCRERNVLFILPYVS 320
            .|:|.::     ............:|.....||..|||:|||:.:.... ....:.:::|.|..:
Yeast  1132 ESIYPFKYFNPMQTMTFYTLYNTNENAFVGSPTGSGKTIVAELAIWHAFKTFPGKKIVYIAPMKA 1196

  Fly   321 IVQEKV----SAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKR-RSLFIASIEKGAVLMDSLIDVQ 380
            :|:|:|    ..::|...|.   |.|.|   |...|.|:... .::.|.:.||...:..:....:
Yeast  1197 LVRERVDDWRKKITPVTGDK---VVELT---GDSLPDPKDVHDATIVITTPEKFDGISRNWQTRK 1255

  Fly   381 RPHEIGLVVVDELHLIGEKGRGATLEAFLTKVMFLNAN----IQIVGMSATIGNLSEISSFLNAD 441
            ...::.|:::||:||:. ..||..||..::::.::::.    ::::|||..:.|..:::.:|...
Yeast  1256 FVQDVSLIIMDEIHLLA-SDRGPILEMIVSRMNYISSQTKQPVRLLGMSTAVSNAYDMAGWLGVK 1319

  Fly   442 -----VYTRGFRPVELKEYIKCGPDLLEINSAGQTLEE-IFVPSRSVEYNYSEAVKRADPDHLAG 500
                 .:....|||.||.||...||.|......:|:.: :|:           |:|:..||..|
Yeast  1320 DHGLYNFPSSVRPVPLKMYIDGFPDNLAFCPLMKTMNKPVFM-----------AIKQHSPDKPA- 1372

  Fly   501 LISECAPEHCCLVFCPSRKNCENVALLLSRIV-----PKHKFFEHRRSEKLDLMDALDKMCGILS 560
                       |:|..||:.....||.|..:.     |: :|......|:|...     :..:..
Yeast  1373 -----------LIFVASRRQTRLTALDLIHLCGMEDNPR-RFLNIDDEEELQYY-----LSQVTD 1420

  Fly   561 PVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIR------A 619
            ..|..:|.:||..||:||...:|......::...:.::..|||||.||||||..|||:      |
Yeast  1421 DTLKLSLQFGIGLHHAGLVQKDRSISHQLFQKNKIQILIATSTLAWGVNLPAHLVIIKGTQFFDA 1485

  Fly   620 PYVGQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQS------KDNLLVGQMLFSPMDKAL---- 674
            ...|...:.|....||:|||||......|.:|:..:.      |..|.||..:.|.:.|.|
Yeast  1486 KIEGYRDMDLTDILQMMGRAGRPAYDTTGTAIVYTKESKKMFYKHFLNVGFPVESSLHKVLDDHL 1550

  Fly   675 -------SSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLEVAVNEIVLRIL 732
                   |..::.||:...|.....        ||..:   |.|...::..:....|:|.:..::
Yeast  1551 GAEITSGSITNKQEALDFLSWTFLF--------RRAHH---NPTYYGIEDDTSTAGVSEHLSSLI 1604

  Fly   733 REMFKNKVLQLAEPQAKSKINSSDIITSQDVSQANRPAGDRRLLIGQSTPFKLTNIGRAAFKAGI 797
            ....:|    |.|.|. ..::..||:                     :|||    :..:::.
Yeast  1605 DSTLEN----LRESQC-VLLHGDDIV---------------------ATPF----LSISSYY--- 1636

  Fly   798 DYKRANAIHKELKQAQQQLILTNYLHLLYLVVCFNS-NERGDELFPADASILFGVYTSLPLDSQA 861
             |.....|.:.|||..........|..|.|.|.:|. ..||.|:...:           .:..|:
Yeast  1637 -YISHLTIRQLLKQIHDHATFQEVLRWLSLAVEYNELPVRGGEIIMNE-----------EMSQQS 1689

  Fly   862 MFK-QLGFTEAHAARLFKTQSVQGPLSLQLNRLYKVLILADILNLLPIPSVASKYNVERGTLQHL 925
            .:. :..||:.....::... |:..|.||.:.....|.:||.:               :.|:. :
Yeast  1690 RYSVESTFTDEFELPMWDPH-VKTFLLLQAHLSRVDLPIADYI---------------QDTVS-V 1737

  Fly   926 ISQSTAAASAIVRLCEELEEFWCYKPLFERILHKMDRC----GTFELEPLMELPAVKINRARQ-- 984
            :.||.....|.:.:..||..|.....:.     ||.:|    ..:|.:|:..||.:::.|.:.
Yeast  1738 LDQSLRILQAYIDVASELGYFHTVLTMI-----KMMQCIKQGYWYEDDPVSVLPGLQLRRIKDYT 1797

  Fly   985 LYAAGF------------QTIGDIARVRPSHLVQSLEHMPLRVATEIVSAAK--IILMKKLDHLE 1035
            ....||            .|:.:|.|.....|:...:.:...: ||.....|  :.:.::|..||
Yeast  1798 FSEQGFIEMTPQQKKKKLLTLEEIGRFGYKKLLNVFDQLTFGM-TESEDTKKRFVSVCQRLPVLE 1861

  Fly  1036 ----EETEN 1040
                ||.||
Yeast  1862 GMKFEEQEN 1870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	46/227 (20%)
		BRR2	255..828	CDD:440817	139/621 (22%)
SLH1	NP_011787.4	BRR2	283..832	CDD:440817
		DEXHc_ASCC3_1	287..489	CDD:350778
		Sec63	795..1099	CDD:460740	48/266 (18%)
		BRR2	1136..1655	CDD:440817	133/599 (22%)
		DEXHc_ASCC3_2	1139..1327	CDD:350780	39/194 (20%)
		SEC63	1623..1967	CDD:214744	59/311 (19%)