Protein Alignment mus301 and HFM1

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_011263.2
• Gene: HFM1 / 852641
• SGDID: S000003220
• Length: 1187
• Species: Saccharomyces cerevisiae
• Alignment Length: 1079
• Identity: 246/1079 - (22%)
• Similarity: 397/1079 - (36%)
• Gaps: 348/1079 - (32%)

  Fly    80 DGLGLFADTSFPSAQSVPPNSAS---KPDEASAPTDKHQIDLA--------DEENADKLFKKINL 133
            |.||. ...|.||..::..|..|   |.::.::.....::.|:        |:||
Yeast     6 DRLGT-GKRSRPSPNNIDFNDQSATFKRNKKNSRQPSFKVGLSYNSLLDDCDDEN---------- 59

  Fly   134 NDLSIAEMEDIFHGA--------DDFS---DPMVQNTQLF---LDAMTFKKPKTPEKLLAPLKDD 184
                  |.|:||.|.        |:||   |.....::||   |:....::.|.|:|:  .::..
Yeast    60 ------ETEEIFEGRGLQFFDKDDNFSITADDTQVTSKLFDHDLEQTPDEEAKKPKKV--TIRKS 116

  Fly   185 SMSFISKSVIEGLVQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKGEFYGLPD 249
            :...:|.:::....:|                       .|...|.|....:.||
Yeast   117 AKKCLSTTILPDSFRG-----------------------VFKFTEFNKMQSEAFP---------- 148

  Fly   250 KVKKMILEHKGINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERN--- 311
                         |:||..:.|            |.:.||..|||::.|:.:||  |.:|.|
Yeast   149 -------------SIYESNENC------------IISSPTGSGKTVLFELAILR--LIKETNSDT 186

  Fly   312 ----VLFILPYVSIVQEKVSAMSPFAI---------DLDFIVEEYTAGKGKCPPQPRRKRRSLFI 363
                :::|.|..|:..|......|..:         |..|:..|            :.|:.::.|
Yeast   187 NNTKIIYIAPTKSLCYEMYKNWFPSFVNLSVGMLTSDTSFLETE------------KAKKCNIII 239

  Fly   364 ASIEKGAVLMDSLIDVQRPHE-IGLVVVDELHLIGEKGRGATLEAFLTKVMFLNANIQIVGMSAT 427
            .:.||..:|.....|..|..| :.||:|||:|.|.|| |||:||..||::..:..||:.|.:|||
Yeast   240 TTPEKWDLLTRRWSDYSRLFELVKLVLVDEIHTIKEK-RGASLEVILTRMNTMCQNIRFVALSAT 303

  Fly   428 IGNLSEISSFL--------NADVYTRGFRPVELKEYI-----KCGPDLLEINSAGQTLEEIFVPS 479
            :.|:.:::.:|        |...:...:|.|:|.:::     .|..|.                .
Yeast   304 VPNIEDLALWLKTNNELPANILSFDESYRQVQLTKFVYGYSFNCKNDF----------------Q 352

  Fly   480 RSVEYNYSEAVKRADPDHLAGLISECAPEHCCLVFCPSRKNCENVA--LLLSRIVPK-HKFFEHR 541
            :...||          ..|..:|.:.|.....|:|||:|.:..:.|  ||.:.|..| .|...|.
Yeast   353 KDAIYN----------SKLIEIIEKHADNRPVLIFCPTRASTISTAKFLLNNHIFSKSKKRCNHN 407

  Fly   542 RSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAA 606
            .|:|                :|.:.:..|||:||:|::.::|..:|..:..|.:.::|.|||||.
Yeast   408 PSDK----------------ILNECMQQGIAFHHAGISLEDRTAVEKEFLAGSINILCSTSTLAV 456

  Fly   607 GVNLPAKRVIIRAPYVG-----QEFLTLCKYKQMVGRAGRAGLGEAGESILIAQSK-----DNLL 661
            ||||||..|||:.....     ||:..| ...||:|||||......|.::::..||     :||:
Yeast   457 GVNLPAYLVIIKGTKSWNSSEIQEYSDL-DVLQMIGRAGRPQFETHGCAVIMTDSKMKQTYENLI 520

  Fly   662 VGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLEVAVNE 726
            .|      .|...|||.                |||.|      .|...|.|.. ..|:|.|||
Yeast   521 HG------TDVLESSLH----------------LNLIE------HLAAETSLET-VYSIETAVN- 555

  Fly   727 IVLRILREMF------KNKVLQLAEPQAKSKINSSDIITSQDVSQANRPAGDRRLLIGQSTPFKL 785
                .||..|      ||       |.|..::|......|.:.||.|:..   :.|:......|:
Yeast   556 ----WLRNTFFYVRFGKN-------PAAYQEVNRYVSFHSVEDSQINQFC---QYLLDTLVKVKI 606

  Fly   786 TNIGRAAFKAGIDYKRANAIH-------KELKQAQQQLILTNYLHLL-----YLVVCFNSNERGD 838
            .:|....:|: ..|..|...|       |:...|::.|.|...|:||     :.|:....||:
Yeast   607 IDISNGEYKS-TAYGNAMTRHYISFESMKQFINAKKFLSLQGILNLLATSEEFSVMRVRHNEK-- 668

  Fly   839 ELFPADASILFGVYTSLPLDSQAMFKQLGFTEAHAARLFKTQSVQGPLSLQLNRLYKVLILADIL 903
                                  .:||::..:.. ....|.|:..|..:..::::...:||..: |
Yeast   669 ----------------------KLFKEINLSPL-LKYPFLTEKKQSQIIDRVSQKVSLLIQYE-L 709

  Fly   904 NLLPIPSV--ASKYNVERGTLQHLISQSTAAASAIVRLCEELEEFWCYKPLFERILHKMDRCGT- 965
            ..|..||.  |||.:      |.|:...    ..:.|.|     |...|.:.:..:.|.|  ||
Yeast   710 GGLEFPSYEGASKLH------QTLVQDK----FLVFRHC-----FRLLKCMVDTFIEKSD--GTS 757

  Fly   966 -----FELEPL-----MELPAVKINRARQLYAAGFQTIGDIARVRPSHLVQSLEHM--------- 1011
                 |.|..|     ...|.|    .|||...|..::..:.|    |.:.:||.|
Yeast   758 LKNTLFLLRSLNGHCWENTPMV----LRQLKTIGLVSVRRLIR----HGITNLEEMGHLSDTQIE 814

  Fly  1012 ---------PLRVATEIVSAAKIILMKKLDHLEEETENL 1041
                     .:::..:|.....:.:..||::.:.|.|.|
Yeast   815 YYLNLKIGNGIKIKNDISLLPCLNIRTKLENCKIENEEL 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	57/226 (25%)
		BRR2	255..828	CDD:440817	164/633 (26%)
HFM1	NP_011263.2	BRR2	121..653	CDD:440817	170/692 (25%)
		SEC63	613..953	CDD:214744	58/293 (20%)