Protein Alignment mus301 and Polq

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_084253.1
• Gene: Polq / 77782
• MGIID: 2155399
• Length: 2544
• Species: Mus musculus
• Alignment Length: 864
• Identity: 262/864 - (30%)
• Similarity: 415/864 - (48%)
• Gaps: 154/864 - (17%)

  Fly   245 YGLPDKVKKMILE--HK-GINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRELL 306
            :|||    |.:||  |. |:..::|||.|||.|..:.:.|||:|:.|||.|||||||:|:|:.:|
Mouse    73 WGLP----KAVLEKYHSFGVRKMFEWQAECLLLGHVLEGKNLVYSAPTSAGKTLVAELLILKRVL 133

  Fly   307 CRERNVLFILPYVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIEKGAV 371
            ...:..|||||:||:.:||...:.....::...|:.|   .|...|..:.....:.:.:||:...
Mouse   134 ETRKKALFILPFVSVAKEKKCYLQSLFQEVGLKVDGY---MGSTSPTGQFSSLDIAVCTIERANG 195

  Fly   372 LMDSLIDVQRPHEIGLVVVDELHLIGEKGRGATLEAFLTKVMF---------------LNANIQI 421
            |::.||:..:...:|:|||||||::|:..||..||..|||:.:               |:..:||
Mouse   196 LVNRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYVTRKSASHQAESASTLSNAVQI 260

  Fly   422 VGMSATIGNLSEISSFLNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPSRSVEYNY 486
            ||||||:.||..::|:|||::|...||||.|.|.||.|..:.:   :...|...|.|...|
Mouse   261 VGMSATLPNLQLVASWLNAELYHTDFRPVPLLESIKIGNSIYD---SSMKLVREFQPLLQV---- 318

  Fly   487 SEAVKRADPDHLAGLISECAPE-HCCLVFCPSRKNCENVALLLSRIVPKHKFFE-HRRSE----- 544
                 :.|.||:..|..|...: |..|:||||:|.||.||.:::|     :|:. |.:.|
Mouse   319 -----KGDEDHIVSLCYETIQDNHSVLIFCPSKKWCEKVADIIAR-----EFYNLHHQPEGLVKS 373

  Fly   545 ------------KLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTV 597
                        .|::||.|.:....|..||..|:|:|:|:||:|||.:||..||.|:|.|.:.|
Mouse   374 SEFPPVILDQKSLLEVMDQLKRSPSGLDSVLKNTVPWGVAFHHAGLTFEERDIIEGAFRQGFIRV 438

  Fly   598 ICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQSKDN--- 659
            :..||||::||||||:|||||.|....:.|.:..||||||||||.|:...|||||:.::.:.
Mouse   439 LAATSTLSSGVNLPARRVIIRTPIFSGQPLDILTYKQMVGRAGRKGVDTMGESILVCKNSEKSKG 503

  Fly   660 --LLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVNSTLLSV------- 715
              ||.|.:  .|:...|....:..|..:::::..:|| .:|...:|:......|.|:.
Mouse   504 IALLQGSL--EPVHSCLQRQGEVTASMIRAILEIIVG-GVASTSQDMQTYAACTFLAAAIQEGKQ 565

  Fly   716 -----QAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSDIITSQDVSQANRPAGDRRL 775
                 |..:...|::..|..:|    :|:.:|:|||
Mouse   566 GMQRNQDDAQLGAIDACVTWLL----ENEFIQVAEP----------------------------- 597

  Fly   776 LIGQSTPFKL---TNIGRAAFKAGIDYKRANAIHKELKQAQQQLILTNYLHLLYLVV-CFNSNER 836
              |..|..|:   |::|.|...:.:.......|..:|::|.:..:|.|.||::|||. .|
Mouse   598 --GDGTGGKVYHPTHLGSATLSSSLSPTDTLDIFADLQRAMKGFVLENDLHIVYLVTPVF----- 655

  Fly   837 GDELFPADASILFGVYTSLPLDSQAMFKQLGFTEAHAARLFK------TQSVQGPLSLQLNRLYK 895
             ::....|....|.::..||...:.:.:.:|..|...||..|      |:.....:::. .|.:.
Mouse   656 -EDWISIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIH-KRFFT 718

  Fly   896 VLILADILNLLPIPSVASKYNVERGTLQHLISQSTAAASAIVRLCEELEEFWCYKPLFERILHKM 960
            .|:|.|:::.:|:..:..||...||.:|.|...:...|..|......|.  |   ...|.:|.:.
Mouse   719 SLVLLDLISEIPLKDINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLG--W---HNMELLLSQF 778

  Fly   961 DRCGTF----ELEPLMELPAVKINRARQLYAAGFQTIGDIARVRPSHLVQSLEH-MPLRVATEIV 1020
            .:..||    ||..|:.:..:...|||.|||:||.|:.|:||...:.:..:|:: :|.:.|
Mouse   779 QKRLTFGIQRELCDLIRVSLLNAQRARFLYASGFLTVADLARADSAEVEVALKNSLPFKSA---- 839

  Fly  1021 SAAKIILMKKLDHLEEETE 1039
                   .|.:|..||..|
Mouse   840 -------RKAVDEEEEAAE 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	82/219 (37%)
		BRR2	255..828	CDD:440817	203/629 (32%)
Polq	NP_084253.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57
		BRR2	75..660	CDD:440817	209/652 (32%)
		Helicase activity. /evidence=ECO:0000305	101..551		168/472 (36%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	215..218		2/2 (100%)
		Interaction with RAD51. /evidence=ECO:0000250|UniProtKB:O75417	844..890		4/8 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	896..955
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1022..1058
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1167
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1266..1288
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1331..1353
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1478..1501
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1557..1591
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1606..1697
		DnaQ_like_exo	1853..2040	CDD:447876
		DNA_pol_A_theta	2046..2539	CDD:176475
		DNA polymerase activity. /evidence=ECO:0000305	2052..2538
		Loop 1. /evidence=ECO:0000250|UniProtKB:O75417	2097..2132
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2104..2124
		Loop 2. /evidence=ECO:0000250|UniProtKB:O75417	2212..2276
		Loop 3. /evidence=ECO:0000250|UniProtKB:O75417	2445..2489