DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus301 and polq

DIOPT Version :9

Sequence 1:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster
Sequence 2:	NP_001184156.2	Gene:	polq / 733897	XenbaseID:	XB-GENE-996022	Length:	2671	Species:	Xenopus tropicalis

Alignment Length:	1122	Identity:	300/1122 - (26%)
Similarity:	471/1122 - (41%)	Gaps:	281/1122 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 HNLCKKR----SLDLSEESTSESHAKRQCTENLFWPEGEDDDSFFSNAHLEDLLDGRKEELFGTQ 65
            ||..|:.    |...||.|||.|..||........|...                        |.
Frog    50 HNSRKRNRPTSSSPGSESSTSPSSPKRATVGRQNRPRPH------------------------TS 90

  Fly    66 ATTSTNKMTQSGSD---DGLGLFADTSFPSAQSVPPNSASKPDEASAPTDKHQIDLADEENADKL 127
            ..:...:.::||||   :|             ||.| ||.:.....:||  ||..:..::..
Frog    91 RASQRRRRSESGSDTLQNG-------------SVAP-SAHRDFILFSPT--HQASILGKQKG--- 136

  Fly   128 FKKINLNDLSIAEMEDIFHGADDFSDPMVQNTQLFLDAMTFKKPKTPEKLLAPLKDDSMSFISKS 192
                                    .:|......|.:..:|     .|..|...|.|.|.  :::|
Frog   137 ------------------------QEPQRSRANLSVSVLT-----PPAGLERSLIDSSR--LNES 170

  Fly   193 VIEGLVQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKGEFYGLPDKVKKMILE 257
            |. |..||......:.|.::.:|  .:|                         |||    |.:||
Frog   171 VC-GSGQGPHMAVPDALADKLML--ASW-------------------------GLP----KTVLE 203

  Fly   258 ---HKGINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILPYV 319
               ..|::.::|||.|||.|..:.:.|||:|:.|||.|||||||:|:|:.:|...|..|||||:|
Frog   204 KYGSLGVSQMFEWQAECLMLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLETRRKALFILPFV 268

  Fly   320 SIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDVQRPHE 384
            |:.:||...:.....::...|:.|   .|...|........:.:.:|||...|::.||:..:...
Frog   269 SVAKEKTFYLQNLFQEVGVKVDGY---MGSSSPAGGFCSLDVAVCTIEKANGLVNRLIEENKIDL 330

  Fly   385 IGLVVVDELHLIGEKGRGATLEAFLTKVMFLN--------------AN-IQIVGMSATIGNLSEI 434
            :|::||||||::|:..||..||..||||.::.              || :||||||||:.||..:
Frog   331 LGMMVVDELHMLGDSHRGYLLELLLTKVRYVTQKGAVGRKAEGAGPANDVQIVGMSATLPNLGLL 395

  Fly   435 SSFLNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPSRSVEYNYSEAVKRADPDHLA 499
            :::|:|::|...||||.|.|.:|.|..:.:.|.......|..:|            .:.|.||:.
Frog   396 AAWLDAELYHTDFRPVPLLERVKIGRTVYDSNMVAVREFEPLLP------------VKGDDDHIV 448

  Fly   500 GLISECA-PEHCCLVFCPSRKNCENVALLLSRIVPKHKFFE--HRRSEK---------------- 545
            .|..|.. ..|..|:||||:..||.:|..::|     :|:.  ||..::
Frog   449 SLSYETVRGGHSILIFCPSKNWCEKLADTIAR-----EFYNLFHRAQQRGDAGGSDSFVPPVALD 508

  Fly   546 ----LDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAA 606
                .|:||.|.:....|..||.:|:|:|:|:||:|||.|||..:|.|:|.|.|.|:..||||::
Frog   509 RDGIRDVMDQLKRSPAGLDAVLGRTVPWGVAFHHAGLTFDERDIVEGAFRQGFVRVLAATSTLSS 573

  Fly   607 GVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQSKDNLLVGQMLFSPMD 671
            ||||||:|||||:|......|.:..||||.|||||.|:...|||||:.::.:......:|...:.
Frog   574 GVNLPARRVIIRSPLFNGRLLDILTYKQMAGRAGRKGVDTEGESILVCKNPERAKGISLLQGSLK 638

  Fly   672 KALSSLDQNEAVGLQS----LILSVVGLNLAECRRDLNRLVNSTLLSVQAK-------------S 719
            ...|.|.:.|..|:..    .||.::...:|:...|:....:.|||:...|             :
Frog   639 PVQSCLLRKEGAGVTGSMIRAILEIIVGGVADTPEDVRIYASCTLLAASMKQGGGDQEEEHGGGA 703

  Fly   720 LEVAVNEIVLRILREMFKNKVLQ-LAEPQAKSKINSSDIITSQDVSQANRPAGDRRLLIGQSTPF 783
            :|..|:.::        :|:.:| |.|.:..:|            ::..||
Frog   704 IEACVDWLL--------RNEFIQILEEDRGGTK------------AEVYRP-------------- 734

  Fly   784 KLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLILTNYLHLLYLVVCFNSNERGDELFPADASIL 848
              |.:|.|...:.:....|..|..:|::|.:..:|.|.||:||||....     :|....|....
Frog   735 --TKLGAATLSSSLSPSEALGIFADLQRAMKGFVLENDLHILYLVTPVY-----EEWTTIDWYQF 792

  Fly   849 FGVYTSLPLDSQAMFKQLGFTEAHAARLFKTQSVQGPLSLQLN----------RLYKVLILADIL 903
            |.::..||...:.:.:.:|..|...||     ||.|.:..:.:          |.:..|:|.|::
Frog   793 FCLWEKLPTSMKRVAELVGIEEGFLAR-----SVNGKIVAKNDRQHRQIAIHRRFFTSLVLLDLI 852

  Fly   904 NLLPIPSVASKYNVERGTLQHLISQSTAAASAIVRLCEE----------LEEFWCYKPLFERILH 958
            :.:.:..:..||...||.||.| .||.|..:.:|.:...          |.:|.      .|:..
Frog   853 SEVSLKELTKKYGCSRGQLQSL-QQSAATYAGMVTVFSNRLGWHNMELLLSQFQ------SRLTF 910

  Fly   959 KMDRCGTFELEPLMELPAVKINRARQLYAAGFQTIGDIARVRPSHLVQSLEH-MPLRVATEIVSA 1022
            .:.|    ||..|:.:..:...|||.||.||..|:.::||.....:..:|:: :|.:...:.|
Frog   911 GVQR----ELCDLVRVDLLNAQRARALYNAGLVTVAELARAHVIDVETALKNAVPFKSGRQAV-- 969

  Fly  1023 AKIILMKKLDHLEEETE 1039
                     |..||..|
Frog   970 ---------DEEEEAAE 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	BRR2	247..998	CDD:224125	246/829 (30%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	82/219 (37%)
polq	NP_001184156.2	BRR2	179..953	CDD:224125	252/881 (29%)
		DEXHc_POLQ-like	197..410	CDD:350784	82/219 (37%)
		Med15	<1034..>1279	CDD:312941
		DnaQ_like_exo	1984..2171	CDD:385652
		DNA_pol_A_theta	2177..2666	CDD:176475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103838at33208
OrthoFinder	1	1.000	-	-		FOG0001214
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010