Protein Alignment mus301 and Hfm1

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_001399493.1
• Gene: Hfm1 / 690161
• RGDID: 1584010
• Length: 1474
• Species: Rattus norvegicus
• Alignment Length: 622
• Identity: 145/622 - (23%)
• Similarity: 261/622 - (41%)
• Gaps: 137/622 - (22%)

  Fly   199 QGTQYVTCEELKNQSL----LDPVNWETQAFADFEKNNQDIDKFPSKG-----EFYGLPDKVKKM 254
            |..||.|.:...|.:.    ::...:|..:|: .....:||....|.|     ....:|.|.:.:
  Rat   210 QKLQYSTDKSKANDAFSASGIEKDIFEAPSFS-AASQPRDIQGITSNGLGSLKAVTEIPAKFRSV 273

  Fly   255 ILEHKGINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILPYV 319
            ..|....|.:   |.:..: ..:...:|.:...||..|||:|.|:.:.|.|:...      ||::
  Rat   274 FKEFPYFNYI---QSKAFD-DLLYTDRNFVICAPTGSGKTVVFELAITRLLMEAP------LPWL 328

  Fly   320 SIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIE-KGAVLMDSLIDVQR-- 381
            ::   ||..|:|...   ...:.:...|.|..|        :.:...| .|..:||.|.::|.
  Rat   329 NM---KVVYMAPIKA---LCSQRFDDWKEKFGP--------IGLTCKELTGDTVMDDLFEIQHAN 379

  Fly   382 -----PHE----------------IGLVVVDELHLIGEKGRGATLEAFLTKVMFLN--------- 416
                 |.:                :.|.::||:|:|.::.||.|||..::::..:.
  Rat   380 IIMTTPEKWDSMTRKWRDNSFIQLVRLFLIDEVHVIKDENRGPTLEVVVSRMKTVQSLSKTLENA 444

  Fly   417 --ANIQIVGMSATIGNLSEISSFLNAD-------VYTRGFRPVELKEYIKCGPDLLEINSAGQTL 472
              |.::.|.:||||.|..:|:.:|:..       ......|||:|::.:...|     :|:.||
  Rat   445 SPAPVRFVAVSATIPNAEDIAEWLSDGERPAVCLKMDESHRPVKLQKVVLGFP-----SSSNQT- 503

  Fly   473 EEIFVPSRSVEYNYSEAVKRADPDHLAGLISECAPEHCCLVFCPSRKNCENVALLLSRIVPKHKF 537
                      |:.:..|:..    .:..:|...:.:...||||.:||..:..|   |.:|...||
  Rat   504 ----------EFKFDLALNY----KVYSVIRTYSDQKPTLVFCATRKGVQQAA---SVLVKDAKF 551

  Fly   538 FEHRRSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTS 602
            . ....:||.|..:   ...|....|..||.||:.|||:|:...:||.:|..:..|.:.|:..||
  Rat   552 I-ITVEQKLRLQKS---AYSIRDSKLKDTLVYGVGYHHAGMELSDRKLVEELFTSGDLPVLFTTS 612

  Fly   603 TLAAGVNLPAKRVIIRAP--YVGQEFLTLCKYK-----QMVGRAGRAGLGEAGESILIAQSKDNL 660
            |||.||||||..|:|::.  |.|..|.   :|.     ||:|||||........::::.:.....
  Rat   613 TLAMGVNLPAHLVVIKSTMHYTGGAFE---EYSETDILQMIGRAGRPQFDTTATAVIMTRLSTRE 674

  Fly   661 LVGQMLFSPMDKALSSLDQN--EAVGLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQA------ 717
            ...||| :..|...|||.::  |.:..:.::.::..:::|     |: .:.||||.::|
  Rat   675 KYVQML-ACNDTVESSLHRHLIEHLNAEIVLHTITDVSIA-----LD-WIRSTLLYIRALKNPSH 732

  Fly   718 ---------KSLEVAVNEIVLRILREMFKNKVLQLAE 745
                     ..:|..:.|:.|:.|:::....::::.|
  Rat   733 YGFISGLNKDGIEAKLQELCLKNLKDLSSLDLIKMDE 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	50/243 (21%)
		BRR2	255..828	CDD:440817	132/557 (24%)
Hfm1	NP_001399493.1	BRR2	263..795	CDD:440817	134/568 (24%)
		DEXHc_HFM1	279..486	CDD:350781	47/230 (20%)
		Sec63	775..1088	CDD:460740