Protein Alignment mus301 and poln

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_001093496.1
• Gene: poln / 566857
• ZFINID: ZDB-GENE-100917-1
• Length: 1146
• Species: Danio rerio
• Alignment Length: 1208
• Identity: 211/1208 - (17%)
• Similarity: 348/1208 - (28%)
• Gaps: 431/1208 - (35%)

  Fly    78 SDDGLGLFADTSFPSAQSVPPNSASKPDEASAPTDKHQIDLADEENADKL----FKKINLNDLSI 138
            :|.....::|..|..||.......:....:....|.:..:||:..|:.:|    ..|..|| |.|
Zfish    33 ADRSRATWSDQGFGMAQQQDGEDRNVELHSGNSRDLNLNELAEHSNSSELEDMAIDKFALN-LPI 96

  Fly   139 AEMEDIFHGADDFSDPMVQN-----------------------------TQLFLDAMTFKKPKTP 174
            .| ..:|..||:...|:.|:                             ||..:...||:|.|..
Zfish    97 IE-RFVFDHADNIITPIGQHFTPSVQGEDSLQTFCLTSMGSPQARADVITQSEIHGRTFRKRKWI 160

  Fly   175 EKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFP 239
            :....|.:|             ||..:|..| ..:|..:.:.|::....||.:..|....:||..
Zfish   161 QPASPPEQD-------------LVGCSQPET-PPMKKFNFMLPIDNCQPAFGEEGKMIDIVDKRN 211

  Fly   240 SKGEFYGLPDK------------------------------VKKMILEHKGINSLYEWQD----- 269
            :.|:.: ||:|                              ..|.:||     :.:.|::
Zfish   212 NNGQPW-LPEKENSDSVSEDRAAFIEVQLGSLRCISNVDMITSKCVLE-----TSHYWEESRNCQ 270

  Fly   270 --------------------ECLNLPAIRQRK-------------------NLIYALPTSGGKTL 295
                                ||....|.|..|                   .|..:.|.|...|:
Zfish   271 LSVPMENSPDAKRCESISVFECQQDTANRSDKMMDSSREKVDNGTERRDITKLRTSSPQSDDNTV 335

  Fly   296 VAEILMLRELLC---RERNVL--FILPYVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCP---- 351
            |..:|. .|:.|   ..||.:  .|.|:...|:  |::.|..            |||.:.|
Zfish   336 VMPVLE-GEMECAASSSRNAMQHSIQPHSQAVE--VTSFSKH------------AGKWEPPGPSQ 385

  Fly   352 ---------------------------------PQP--RRKRR---------------------- 359
                                             |||  :|:||
Zfish   386 KALCKKTFRNPRFPIQLFHQVNGSMRLLKQRKAPQPMVKRQRRLLRPQKIFKSKRGKKQNKLTKT 450

  Fly   360 --SLFIASIEKGAVLMD----------------SLIDVQRPHEIGLVVVDELH-LIGEKGRGATL 405
              |....|.|...:|.:                |||...|..:.|.|..:|.. ::.|.|:.
Zfish   451 SDSSLSGSKESSHILSETDRKEDGTTTTLKGAFSLISDPRVCDTGRVSQEERECILEETGKA--- 512

  Fly   406 EAFLTKVMFLNANIQIVG----MSATIGNLSEISSFLNA-------------------------- 440
            :||:..:::.:...|:..    .....|.|..:.|.||:
Zfish   513 KAFVVTMVYQDGTTQLDSEQKLCPPVCGLLILLKSELNSEEPLERPPERVLYLRLEQTPAWAQQD 577

  Fly   441 -----DVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPSRSVEYNYSEAVKRADPDHLAG 500
                 |.|.|     |:...|.||........|...|..:....|.:.:......:..||...|.
Zfish   578 FTQKQDAYAR-----EMLLKIMCGTKTFVCFKAKDLLRTVLRHFRDLSWTQVLGCQVMDPQIAAW 637

  Fly   501 LISECAPEHCCLVFCPSRKNCENVALLLSRIVPKHKFFE--------HRRSEKLDLMDALDKMCG 557
            |:.......|...........:.....|..::.:.|..:        |:..|:|........:..
Zfish   638 LLDPADSSSCFQTLLSKHYTHQFTPTTLQPVLEQAKVTQVISNLSLLHKLMEELHYKLRTQGLWQ 702

  Fly   558 ILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPYV 622
            :.|.:..|.:|...|.....:..|:....:|:...|
Zfish   703 LYSGIEQKMIPVLAAMESYKMHVDKEALKKTSEMLG----------------------------- 738

  Fly   623 GQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQSKDNLLVGQMLFSPMDKALSSLDQN----EAV 683
                   .|.||:...|.:|    ||:..|::.|....|:   ||..:  .|..|.:|    :.|
Zfish   739 -------SKLKQLEQEAHQA----AGQKFLVSSSAQLRLI---LFEKL--RLHELCENKKLPKTV 787

  Fly   684 GLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLEVAVNEIVLRILREMFKNKV-------- 740
            ..|........|.|    :.|:.|....|...|...::....:.:|...|:.|.:..
Zfish   788 KQQQSTSETALLQL----QKLHPLPKIILEYRQIHKIKTTFVDGILSCTRKTFISSTWNQTSTVS 848

  Fly   741 --LQLAEP--QAKSKI------------NSSDIIT----------------SQDVSQ------AN 767
              |....|  ||..|:            .:|||:|                |.|..|      |:
Zfish   849 GRLSAKHPNFQALPKLPLQISKKQYIHGKASDIVTVHPRAMFIPREGWTFLSADFCQVELRLLAH 913

  Fly   768 RPAGDRRLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLILTNYLHLLYLVVCFN 832
            ..|..:.|.|.||.......:..|.:| |:...|.:...:|  ||::         ::|.||...
Zfish   914 LSADPQLLRIFQSPEADAFTMLAAQWK-GVSEDRVSLEDRE--QAKR---------IVYSVVYGA 966

  Fly   833 SNERGDELFPADA-------SILFGVYTSLPLDSQAMFKQL---GFTEAHAAR---LFKTQSVQG 884
            ..||...:....|       ......|..:|...|...:..   ||..:...|   |....|...
Zfish   967 GRERLSGILGVSAEEASRFQDSFLKTYREVPAFIQHTIQHCQSHGFVRSIMGRRRFLPHIHSADW 1031

  Fly   885 PLSLQLNRLYKVLIL----ADILNLLPIPSVASKYNVERGTLQHLISQSTAAASAIVRLCEELEE 945
            .|..|..|.....:|    ||:..|..| .:.|:           :|..:..|..:.::.:||
Zfish  1032 SLRNQAERQAVNFVLQGSAADLAKLAMI-RICSQ-----------VSSDSQTARLVAQIHDEL-- 1082

  Fly   946 FWCYKPLFERILHKMDRCGTF---ELEPLMELPAVKIN 980
                  |||..:.::|:....   .:|.|..:..:.:|
Zfish  1083 ------LFEVEISQLDQFAALVKKTMESLQHIEYLNVN 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	61/395 (15%)
		BRR2	255..828	CDD:440817	133/794 (17%)
poln	NP_001093496.1	DNA_pol_P_Exo	492..696	CDD:465627	33/211 (16%)
		DNA_pol_A_theta	723..1132	CDD:176475	88/473 (19%)