Protein Alignment mus301 and DDX60

DIOPT Version :9

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_060101.3
• Gene: DDX60 / 55601
• HGNCID: 25942
• Length: 1712
• Species: Homo sapiens
• Alignment Length: 1300
• Identity: 226/1300 - (17%)
• Similarity: 397/1300 - (30%)
• Gaps: 505/1300 - (38%)

  Fly    92 SAQSVPPNSASKPDEASAPTDK--HQ--IDLADEENADKLF--------KKINLNDLSIAEM--E 142
            |::.:...:.....:.|.|..|  |:  .::...||..:||        :|.|....||.|.  |
Human   550 SSKIIVTQTIKSKKDFSGPKSKKAHETKAEIIARENKKRLFAREEQKEEQKWNALSFSIEEQLKE 614

  Fly   143 DIFHGADDFSD--------------PMVQNT-------------------QLFLDAMTFKK-PKT 173
            ::..|.....|              .||..|                   .|.:.....|: ...
Human   615 NLHSGIKSLEDFLKSCKSSCVKLQVEMVGLTACLKAWKEHCRSEEGKTTKDLSIAVQVMKRIHSL 679

  Fly   174 PEKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCEELKNQSL---------------------LDP 217
            .||....|::|....|::.:        :|:..:||.: ||                     :.|
Human   680 MEKYSELLQEDDRQLIARCL--------KYLGFDELAS-SLHPAQDAENDVKVKKRNKYSVGIGP 735

  Fly   218 VNWETQAFADFEKNNQDIDKFPSKGEFYGLPDKVKKMILEHKGINSLYEWQDECLNLPAIRQRKN 282
            ..::.|....:...::..|..|...:|  :||                .||.|.|::  :.:.::
Human   736 ARFQLQYMGHYLIRDERKDPDPRVQDF--IPD----------------TWQRELLDV--VDKNES 780

  Fly   283 LIYALPTSGGKTLVAEILMLRELLCRERN---VLFILPYVSIVQEKVSAMSPFAIDLDFIVEEYT 344
            .:...|||.|||..:...|  |.:.:|.:   |:::.|..::|.:..:.:.      :...:...
Human   781 AVIVAPTSSGKTYASYYCM--EKVLKESDDGVVVYVAPTKALVNQVAATVQ------NRFTKNLP 837

  Fly   345 AGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDVQ--------RPH------EIGLVVVDELHL 395
            :|:..|         .:|.......|:....||.|.        .||      :|..|:.||:|.
Human   838 SGEVLC---------GVFTREYRHDALNCQVLITVPACFEILLLAPHRQNWVKKIRYVIFDEVHC 893

  Fly   396 IGEKGRGATLEAFLTKVMFLNANIQIVGMSATIGNLSEISSFL---------------------- 438
            :     |..:.|.:.:.:.:......:.:||||.|...::.:|
Human   894 L-----GGEIGAEIWEHLLVMIRCPFLALSATISNPEHLTEWLQSVKWYWKQEDKIIENNTASKR 953

  Fly   439 -----------------------------------------NADVYTRGFRPV------ELKEYI 456
                                                     :.|::...|.|.      .::.|
Human   954 HVGRQAGFPKDYLQVKQSYKVRLVLYGERYNDLEKHVCSIKHGDIHFDHFHPCAALTTDHIERY- 1017

  Fly   457 KCG--PDL-LEINSAGQTLEEIF------------VPSRSVEYNYSEAVKRAD--------PDHL 498
              |  ||| |....:.|..:.:|            .|...:.:|....:|:.|        ...|
Human  1018 --GFPPDLTLSPRESIQLYDAMFQIWKSWPRAQELCPENFIHFNNKLVIKKMDARKYEESLKAEL 1080

  Fly   499 AGLI------------------SECAPEHCCLVF------------CPS----------RKNCEN 523
            ...|                  ::.:||:...:|            .|:          ....|:
Human  1081 TSWIKNGNVEQARMVLQNLSPEADLSPENMITMFPLLVEKLRKMEKLPALFFLFKLGAVENAAES 1145

  Fly   524 VALLL--------------------------SRIVPKHKFFEHRRSEKL--------------DL 548
            |:..|                          .:.:.|.|..:.:..:|.              :|
Human  1146 VSTFLKKKQETKRPPKADKEAHVMANKLRKVKKSIEKQKIIDEKSQKKTRNVDQSLIHEAEHDNL 1210

  Fly   549 MDALDKMCGI----------------LSPVLAKT------------LPYGIAYHHSGLTTDERKY 585
            :..|:|...|                |..|..:.            ...||.||||.::..|::.
Human  1211 VKCLEKNLEIPQDCTYADQKAVDTETLQKVFGRVKFERKGEELKALAERGIGYHHSAMSFKEKQL 1275

  Fly   586 IETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGES 650
            :|..:|.|.:.|:..|.|||.|||:|.|.|:.....|   :|....|:||.|||||.|
Human  1276 VEILFRKGYLRVVTATGTLALGVNMPCKSVVFAQNSV---YLDALNYRQMSGRAGRRG------- 1330

  Fly   651 ILIAQSKDNLLVGQMLF--SPMDKALSSLDQNEAVGLQSLILSVVGLNLAECR----RDLNRLVN 709
                  :|  |:|.:.|  .|..|            :..||.|    |:.|.|    ..:..::.
Human  1331 ------QD--LMGDVYFFDIPFPK------------IGKLIKS----NVPELRGHFPLSITLVLR 1371

  Fly   710 STLLSVQAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSDIITSQ------DVSQANR 768
            ..||:.:....|.|..:::     .:.|:.:|...:|:....:....:.:.|      .:.|...
Human  1372 LMLLASKGDDPEDAKAKVL-----SVLKHSLLSFKQPRVMDMLKLYFLFSLQFLVKEGYLDQEGN 1431

  Fly   769 PAGDRRLL--IGQSTPFKLTNIGRAAFKA-GIDYKRANAIHKELKQAQQQLILTNYLHLLYLVVC 830
            |.|...|:  :....|   :|:...:|.. |:.:.......|..|...|.::....|.|.:|.
Human  1432 PMGFAGLVSHLHYHEP---SNLVFVSFLVNGLFHDLCQPTRKGSKHFSQDVMEKLVLVLAHLF-- 1491

  Fly   831 FNSNERGDELFP---ADASILFGVYTS------LPLDSQAMFKQLGFTEAHAARLFKTQSVQGPL 886
                  |...||   .||.  |..|.|      ||.|         |::|
Human  1492 ------GRRYFPPKFQDAH--FEFYQSKVFLDDLPED---------FSDA--------------- 1524

  Fly   887 SLQLNRLYKVLILADILNLLPIPSVASKYNVE-----------------RGTLQHLISQSTAAAS 934
               |:. |.:.|:.|....|.|.|..:..|.|                 ...:.||:|
Human  1525 ---LDE-YNMKIMEDFTTFLRIVSKLADMNQEYQLPLSKIKFTGKECEDSQLVSHLMS------- 1578

  Fly   935 AIVRLCEE----LEEFWCYKPLFERILHKMD-----RCGTFELE----PLMELPAVKINRARQL- 985
                 |:|    :..|.|....|:..|.:::     ..||..:.    |:: |.....||.|::
Human  1579 -----CKEGRVAISPFVCLSGNFDDDLLRLETPNHVTLGTIGVNRSQAPVL-LSQKFDNRGRKMS 1637

  Fly   986 ---YAAGFQTIGDIA------RVRPSHLVQSLEHMPLRVATEIVSAAKIILMKKLDHLEEETENL 1041
               ||..|...|.:.      |:........|:...|.:.:..||..::        .|.|.:|:
Human  1638 LNAYALDFYKHGSLIGLVQDNRMNEGDAYYLLKDFALTIKSISVSLREL--------CENEDDNV 1694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	BRR2	247..998	CDD:224125	181/1031 (18%)
		DEXHc_POLQ-like	247..449	CDD:350784	42/281 (15%)
DDX60	NP_060101.3	Dob10	762..>1373	CDD:333050	118/689 (17%)
		DEVH box	889..892		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900