Protein Alignment mus301 and POLG

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_002684.1
• Gene: POLG / 5428
• HGNCID: 9179
• Length: 1239
• Species: Homo sapiens
• Alignment Length: 714
• Identity: 145/714 - (20%)
• Similarity: 227/714 - (31%)
• Gaps: 235/714 - (32%)

  Fly   438 LNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPSRSVEYNYSEAVKRADPDHLAGLI 502
            |..|...:.||.:..|:.:   |.|    .|...|.:..:|.:...:.::|...|..|:..|  :
Human   130 LYGDNLDQHFRLLAQKQSL---PYL----EAANLLLQAQLPPKPPAWAWAEGWTRYGPEGEA--V 185

  Fly   503 SECAPEHCCLVF----CPSRKNCENVALLLSRIVP-------KHKFFEHRRSEKLDLMDA----L 552
            ....||...|||    |.:...|..:|:.:|   |       ..:..|.|.|....|..|    |
Human   186 PVAIPEERALVFDVEVCLAEGTCPTLAVAIS---PSAWYSWCSQRLVEERYSWTSQLSPADLIPL 247

  Fly   553 DKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVII 617
            :...|..||.                   :|.:.|               .|..|.|:...|..|
Human   248 EVPTGASSPT-------------------QRDWQE---------------QLVVGHNVSFDRAHI 278

  Fly   618 RAPYVGQ----EFLTLCKYKQMVGRAGRAGLGEAGESILIAQSKDNLLVGQMLFSPMDK------ 672
            |..|:.|    .||........:     :||.....|:.||..:     |:....|..|
Human   279 REQYLIQGSRMRFLDTMSMHMAI-----SGLSSFQRSLWIAAKQ-----GKHKVQPPTKQGQKSQ 333

  Fly   673 -------ALSSLDQNEAVGLQSLILSVVGLN-LAECRRDLNRLVNSTLLSVQAKSLEVAVNEI-- 727
                   |:||.|.          |.:..:| |||..|          |.|....||....|:
Human   334 RKARRGPAISSWDW----------LDISSVNSLAEVHR----------LYVGGPPLEKEPRELFV 378

  Fly   728 --VLRILREMFKNKVLQLAEPQAKSKINSSDIITSQDVSQANRPAGDRRLLIGQSTPFKLTNIGR 790
              .::.:||.|::.:...|:          |:..:.:|.|...|      |..:..|..:|..|
Human   379 KGTMKDIRENFQDLMQYCAQ----------DVWATHEVFQQQLP------LFLERCPHPVTLAG- 426

  Fly   791 AAFKAGIDYKRAN---------------AIHKELKQAQQQLILTNYLHLLYLVVCFNSNERGDEL 840
             ..:.|:.|...|               .:.:|:|::...| ..:...||       |.||..|
Human   427 -MLEMGVSYLPVNQNWERYLAEAQGTYEELQREMKKSLMDL-ANDACQLL-------SGERYKE- 481

  Fly   841 FPADASILFGVYTSLPLDSQAMFKQLGFTEAHAARL----------FKTQSVQGPLSLQLNRLYK 895
                ...|:.:...|....|...|::....|.|::|          ...|...||.|.:......
Human   482 ----DPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQEDLGPCSEEEEFQQD 542

  Fly   896 VLILADILNLLPIPSVASKYNVERGTL-------QHLISQSTAAASAIVRLCEELEE-FWCYKP- 951
            |:..|.:..|             :||.       |||    ........:||..|:: .|...|
Human   543 VMARACLQKL-------------KGTTELLPKRPQHL----PGHPGWYRKLCPRLDDPAWTPGPS 590

  Fly   952 ---LFERI-------------LHKMDRCGTFELEPLMELPAVKINRARQLYAAGFQTIGDIARVR 1000
               |..|:             ||..:|.|...|.|.......|:.....|.:||.        |.
Human   591 LLSLQMRVTPKLMALTWDGFPLHYSERHGWGYLVPGRRDNLAKLPTGTTLESAGV--------VC 647

  Fly  1001 PSHLVQSL--EH---------MPLR--VATEIV---SAAKIILMKKLDHLEEETENLKDCLKTS 1048
            |...::||  :|         ||..  :|.|.:   ::|....:::||:||.|.|...:.|:.:
Human   648 PYRAIESLYRKHCLEQGKQQLMPQEAGLAEEFLLTDNSAIWQTVEELDYLEVEAEAKMENLRAA 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	3/10 (30%)
		BRR2	255..828	CDD:440817	88/441 (20%)
POLG	NP_002684.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68
		Does not contribute to polymerase and exonuclease enzymatic activities. /evidence=ECO:0000269|PubMed:10827171	43..55
		DNApol_Exo	121..414	CDD:465664	76/375 (20%)
		Exo I. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268	196..200		2/3 (67%)
		Exo II. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268	267..275		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..340		3/21 (14%)
		Exo III. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268	395..403		2/17 (12%)
		DNA_pol_A	431..>473	CDD:470638	6/42 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..531		4/24 (17%)
		Accessory-interacting determinant. /evidence=ECO:0000269|PubMed:26056153	510..571		14/77 (18%)
		DNA_pol_gammaA	785..1203	CDD:176478
		Trigger loop. /evidence=ECO:0000269|PubMed:37202477	858..864
		Pol A. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268	887..896
		Pol B. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268	943..958
		Pol C. /evidence=ECO:0000303|PubMed:15189144, ECO:0000303|PubMed:8884268	1134..1141