DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus301 and CG5589

DIOPT Version :9

Sequence 1:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster
Sequence 2:	NP_649009.1	Gene:	CG5589 / 39979	FlyBaseID:	FBgn0036754	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	764	Identity:	154/764 - (20%)
Similarity:	265/764 - (34%)	Gaps:	216/764 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 ADTSFPSAQSVPPNSASK----PDEASAPTDKHQIDLADEENADKLFKKINLNDLSIAEMEDIFH 146
            |...|.......|:|..:    |:     ..||:..:..|| :||       :|..|.|.. :..
  Fly    12 AGVRFTKKSKKEPSSKQQLQPLPE-----VSKHEEPVKSEE-SDK-------DDEDITEFR-LLD 62

  Fly   147 GADDFSDPMVQNTQLFLDAMTFKKPKTPEKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCEELKN 211
            | |..:.|            ..|||| .||.|:|                          :||:.
  Fly    63 G-DSSNQP------------KRKKPK-KEKTLSP--------------------------KELEI 87

  Fly   212 QSLLDPVNWETQ---AFADFEKN-NQDIDKFPSKGEFYGLPDKVKKMILEHKGINSLYEWQDECL 272
            |...:..| ||:   ......|| ...:|.|.:....:.:..::::.:|..   |..:....:..
  Fly    88 QKAAEEAN-ETRKQYGIRVLGKNVPPPVDSFGTLTRDFKMLPRLQQNLLSR---NFDHPTPIQMQ 148

  Fly   273 NLPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRER---NVLFILPYVSIVQ----EKVSAMS 330
            .||.:.||:.|:...||..||||.....::..|...:.   ..|.:.|...:.|    |......
  Fly   149 ALPVLLQRRALMACAPTGSGKTLAFLTPIINGLRAHKTTGLRALVLAPTRELAQQIYRECAELTR 213

  Fly   331 PFAIDLDFI--VEEYTAGKG-KCPPQPRRKRRSLFIASIEKGAVLMDS---LIDVQRPHEIGLVV 389
            ...:...||  |.|.....| :|     ::|..:.:::..:...|:..   |:|:.   .:...|
  Fly   214 ETGLRTHFISKVSEAKQKHGAEC-----KQRYDILVSTPNRVRFLLQQEPPLLDLS---HVEWFV 270

  Fly   390 VDELHLIGEKGRGATLEAFLTKVMFLNANIQIVGMSATIGNLSEISSFLNADVYTRGFRPVELKE 454
            :||...:.|:|:.             |...|:..:.|...|.::..:|.:| .||   .|| .|.
  Fly   271 LDEADRLMEEGQN-------------NFKEQLDDIYAACSNPTKCVAFFSA-TYT---VPV-AKW 317

  Fly   455 YIKCGPDLLEI-----NSAGQTLEE--IFVPSRSVEYNYSEAVKRADPDHLAGLISECAPEHCCL 512
            .::...:|:.|     |||.:|:::  :||.|...:......:.|      .||      :...|
  Fly   318 ALRHLKNLVRITIGVQNSATETVQQELLFVGSEGGKLVAIRDLVR------QGL------QPPVL 370

  Fly   513 VFCPSRKNCENVALLLSRIVPKHKFFEHRRSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSG 577
            ||..|::..:             :.||..      |.|      ||...|:           |:.
  Fly   371 VFVQSKERAK-------------QLFEEL------LYD------GINVDVI-----------HAE 399

  Fly   578 LTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRA 642
            .:..:|.....|:|.|.:.|:.||..:..|::.....::|...:..    |...|...:||.|||
  Fly   400 RSQHQRDNCVKAFREGSIWVLICTELMGRGIDFKGVNLVINYDFPP----TTISYIHRIGRTGRA 460

  Fly   643 GLGEAGESILIAQSKD--NLLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAE----CR 701
              |..|.:|.....:|  ||           :.::.:.:|....:...:|.:..:..:|    .:
  Fly   461 --GRPGRAITFFTQEDTSNL-----------RGIALIIKNSGGTVPEYMLQMKKVRKSEAKMRAK 512

  Fly   702 RDLNRLVNSTLLSVQAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSDIITSQDVSQA 766
            :.|:|...||.:..:.|..|               |:|..:|.:.:...||            ..
  Fly   513 KPLDREDISTKIRPETKGDE---------------KHKSTKLKKVERTEKI------------LK 550

  Fly   767 NRPAGDRRLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQ 815
            ||...::.|   .|...||.||......||   ||...:.|:.|....|
  Fly   551 NRKGYEKDL---NSKQKKLGNIKTELKPAG---KRKGNVEKKTKNKNNQ 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	BRR2	247..998	CDD:224125	119/595 (20%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	41/214 (19%)
CG5589	NP_649009.1	SrmB	87..594	CDD:223587	127/635 (20%)
		P-loop_NTPase	123..329	CDD:304359	45/234 (19%)
		HELICc	349..469	CDD:238034	35/173 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100