DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus301 and POLN

DIOPT Version :9

Sequence 1:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster
Sequence 2:	NP_861524.2	Gene:	POLN / 353497	HGNCID:	18870	Length:	900	Species:	Homo sapiens

Alignment Length:	833	Identity:	152/833 - (18%)
Similarity:	276/833 - (33%)	Gaps:	262/833 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KHNLCK------KRSLDLSEESTSESHAKRQCTENLFWPEGEDDDSFFSNA-------------- 48
            ||.|.:      |.|::|..:..:.::...:.::.:...|..||...:.|:
Human   137 KHFLMENINNENKGSINLKRKHITYNNLSEKTSKQMALEEDTDDAEGYLNSGNSGALKKHFCDIR 201

  Fly    49 HLED-----LLDGRKEELFGTQATTSTNKMTQSGSDD-------GLGLFADTSFPSAQSVPPNSA 101
            ||:|     |::..|:..........|:..||.|:|.       |:.:............|...|
Human   202 HLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSSVRGIVVLVKRQAEGGHGCPDAPA 266

  Fly   102 SKPDEASAPTD--------KHQIDLADEENADKLFKKINLNDLSIAEMEDIFHGADDFSDPMVQN 158
            ..|......:|        :|......|:.|.:.|.:..|......:...|...|.||...::
Human   267 CGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARNVLFQTMKCKCPVICFNAKDFVRIVL-- 329

  Fly   159 TQLFLDAMTFK--------KPKTPEKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCEELKNQSLL 215
             |.|.:..::|        .|:....|:.| .|.:.||      |.||:  :|  ||    :|:.
Human   330 -QFFGNDGSWKHVADFIGLDPRIAAWLIDP-SDATPSF------EDLVE--KY--CE----KSIT 378

  Fly   216 DPVNWETQAFADFEKN--NQDIDK-----------FPSKGEFYGLPDKVKKM---------ILEH 258
            ..||   ..:.:..:|  ||::.:           ..||.:.|||....:.:         ::|.
Human   379 VKVN---STYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMES 440

  Fly   259 KGINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLREL--------LCRERNVL-- 313
            ..|....|..::...|...|.::....|...:|.:.|:.....|||:        |..:||.|
Human   441 HAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPR 505

  Fly   314 -FILPYVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFI----ASIEKGAV-- 371
             .:..|.|..:..::|:.... .|..|:.||         :...|.:|.|:    |.::||::
Human   506 TGLQKYPSTSEAVLNALRDLH-PLPKIILEY---------RQVHKIKSTFVDGLLACMKKGSISS 560

  Fly   372 ------LMDSLIDVQRPHEIGLVVVDELHLI------GEKGRGATLEAFLTKVMFLNANIQIVGM 424
                  .:...:..:.|:..|:    ..|.|      ..||:...:.....:.||::
Human   561 TWNQTGTVTGRLSAKHPNIQGI----SKHPIQITTPKNFKGKEDKILTISPRAMFVS-------- 613

  Fly   425 SATIGNLSEISSFLNADVYTRGFRPVELK--EYIKCGPDLLEINSAGQTLEEIF---------VP 478
                   |:..:||.||     |..:||:  .::...|:||::....:. :::|         ||
Human   614 -------SKGHTFLAAD-----FSQIELRILTHLSGDPELLKLFQESER-DDVFSTLTSQWKDVP 665

  Fly   479 SRSVEYNYSEAVKR--------ADPDHLAGLISECAPEHCCLVFCPSRKNCENVALLLSRIVPKH 535
            ...|.:...|..|:        |..:.||..:.  .|             .:..|..|...:.|:
Human   666 VEQVTHADREQTKKVVYAVVYGAGKERLAACLG--VP-------------IQEAAQFLESFLQKY 715

  Fly   536 KFFEHRRSEKLDLMDALDKMC---GILSPVLAKTLPY-GIAYHHSGLTTD-ERKYIETAYRFGVV 595
            |..:       |...|....|   |.:..::.:..|. .|..|...|... ||:.:....: |..
Human   716 KKIK-------DFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQ-GSA 772

  Fly   596 TVIC------CTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGESILIA 654
            ..:|      ..:.:||...|.|:                                      |:|
Human   773 ADLCKLAMIHVFTAVAASHTLTAR--------------------------------------LVA 799

  Fly   655 QSKDNLLVGQMLFSPMD-----------KALSSLDQNEAVGLQSLILSVVGLN 696
            |..|     ::||...|           :.:.||:|.:|:.||..:...|.|:
Human   800 QIHD-----ELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLS 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	BRR2	247..998	CDD:224125	93/529 (18%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	43/239 (18%)
POLN	NP_861524.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..90
		DnaQ_like_exo	273..436	CDD:299142	36/183 (20%)
		DNA_pol_A_theta	443..855	CDD:176475	91/506 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900