Protein Alignment mus301 and PolG1

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_476821.1
• Gene: PolG1 / 34792
• FlyBaseID: FBgn0004406
• Length: 1145
• Species: Drosophila melanogaster
• Alignment Length: 736
• Identity: 151/736 - (20%)
• Similarity: 244/736 - (33%)
• Gaps: 231/736 - (31%)

  Fly    90 FPSAQSVPPNSASKPDEASAPTDK-----HQIDLADEENADKLFKKINLNDLSIAEMEDIFHGA- 148
            ||.|    |.|.|:...|||...|     |.:|:  |.:|.....::.|..|..|.:|:.||..
  Fly    70 FPQA----PRSISEQQVASAKVYKDELRRHGVDI--ESSAPVSDVQLKLPALRGANIEEHFHNIA 128

  Fly   149 -------DDFSDPMVQNTQLFLDAMTFKKPK-----------TPEKLLA-----PLKDDSMSFIS 190
                   ::...|:||..||      .|:||           .||...|     ||:...:..:.
  Fly   129 KEQVQPYEELLLPLVQCEQL------PKRPKRWAFHTGWTAYDPEDGTATPVDHPLEKGLVFDVE 187

  Fly   191 KSVIEGLVQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKGEFYGLPDKVKKMI 255
            ..|.||  |.....|....|        .|.:...:...|:...::|
  Fly   188 VCVSEG--QAPVLATAVSTK--------RWYSWVSSKLTKHRLSVEK------------------ 224

  Fly   256 LEHKGINSLYE----WQDECLNL----PAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERNV 312
            ||...:::..|    ..||.:.|    |.:....|:.|      .:..:.|..:..:...|..:.
  Fly   225 LEPLDVDTDSERPHYTTDELIPLGTTGPGLVVGHNVSY------DRARLKEQYLTEDTGTRFVDT 283

  Fly   313 LFILPYVSIVQEKVSAM-----SPFAIDLDFI----------VEEYTAGKGKCPPQPRRKRRSLF 362
            :.:...||.|.....||     .|.|.||.::          |.....|......:|    |::|
  Fly   284 MSLHMCVSGVTSYQRAMLKSKKEPAAEDLGWLEQSSLNSLVEVHRLYCGGDTLSKEP----RNIF 344

  Fly   363 I-ASIEKGAVLMDSLI-----DVQRPHEIGLVVVDELH---------LIGEKGRGATL------- 405
            : .::|:......||.     ||:..|.| |.|:..|:         |.|....|:..
  Fly   345 VEGTLEQVRQSFQSLTNYCASDVEATHRI-LRVLYPLYAERFPHPASLAGMLEMGSAYLPVNSNW 408

  Fly   406 EAFLTKVMFLNANIQIVGMSATIGNLSEISSFLNADVYTRGF---------RPVELKEYIKCGP- 460
            |.::.:......::.|...........|..|.|..|.|.:..         :.::||:..|..|
  Fly   409 ERYIREAQLTYEDLSIEAKYHLGRRAEEACSLLLDDQYRQNLWLWDEDWSVQELKLKQPPKRKPL 473

  Fly   461 DLLEINSAGQTLEEIFVPSRSVEYNYSE-------------------------AVKRAD------ 494
            ..:|:..:|.|.||..:.:: .::.|.:                         ..||||
  Fly   474 PTVELKDSGNTPEERRLQAK-FQHLYDQQALLPARRPLLPGYPLWYRKLCRKPPAKRADEILEDD 537

  Fly   495 -----PDHLAGLIS---ECAPEHCCLVFC------------------PSRKNCENV------ALL 527
                 |.  |..||   :.||:  .|..|                  |.|.:.|.|      .||
  Fly   538 EEPWSPG--ASEISTGMQIAPK--LLSLCWEGYPLHYEREQGWGFLVPFRSDSEGVDRLPMEQLL 598

  Fly   528 LSRIVPKHKFFEHRRSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYR- 591
            ....||:   |....:.|.:...|.|.:.|.:...|.|      ..|:..|:..::: :||.|:
  Fly   599 AHCPVPE---FARLSASKAESDMAFDMLPGQVEQHLGK------REHYKKLSQKQQR-LETQYQG 653

  Fly   592 FGV----VTVICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGESIL 652
            .||    |...||........|.|:.||   ...:.::||.  |:.:.|..:|......|...|.
  Fly   654 SGVWCNKVLDDCCFFLKLPHKNGPSFRV---GNPLSKDFLN--KFAENVLSSGDPSCQAAARVID 713

  Fly   653 IAQ-------SKDNLLVGQML 666
            ||:       ::|.:: |||:
  Fly   714 IARMMSYWRNNRDRIM-GQMV 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	45/255 (18%)
		BRR2	255..828	CDD:440817	109/542 (20%)
PolG1	NP_476821.1	DNApol_Exo	107..381	CDD:465664	62/318 (19%)
		DNA_pol_A	398..>440	CDD:470638	4/41 (10%)
		DNA_pol_gammaA	705..1107	CDD:176478	8/30 (27%)