Protein Alignment mus301 and Snrnp200

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: NP_796188.2
• Gene: Snrnp200 / 320632
• MGIID: 2444401
• Length: 2136
• Species: Mus musculus
• Alignment Length: 1144
• Identity: 253/1144 - (22%)
• Similarity: 414/1144 - (36%)
• Gaps: 329/1144 - (28%)

  Fly    14 DLSEESTSESHAKRQCT--ENLFWPEGE------------DDDSFFSNAHLEDLLDGRKEELFGT 64
            :.|::......|..:||  .||. ..||            |.|:|:....|....|   :.:...
Mouse   223 EASDDDMEGDEAVVRCTLSANLV-ASGELMSSKKKDLHPRDIDAFWLQRQLSRFYD---DAIVSQ 283

  Fly    65 QATTSTNKMTQSGSDD-----------GLGLFAD---------------TSFPSAQSVPPNSASK 103
            :......::.::.|||           |...| |               |...||||.|
Mouse   284 KKADEVLEILKTASDDRECENQLVLLLGFNTF-DFIKVLRQHRMMILYCTLLASAQSEP------ 341

  Fly   104 PDEASAPTDKHQIDLADEENADKLFKKINLNDLSIAEMEDIFHGADDFSDPMVQNTQLFLDAMTF 168
                    :|.:|  ..:..||....|. |..|...|.||:.. .:......|:.:::..|..|.
Mouse   342 --------EKERI--VGKMEADPELSKF-LYQLHETEKEDLIR-EERSRRERVRQSRMDTDLETM 394

  Fly   169 KKPKTPEKLLAPLKDDSMSFISKSV--IEGLV--QGTQYVTCEELKNQSLLDPVNWETQAFADFE 229
            ...:..| .|||          :.|  :|.||  ||:.::.   .|...|.|      .:|....
Mouse   395 DLDQGGE-ALAP----------RQVLDLEDLVFTQGSHFMA---NKRCQLPD------GSFRRQR 439

  Fly   230 KNNQDIDKFPSKGEFYG-----LP-DKVKKMI-LEHKGINSLYEWQDECLNLPAIRQRKNLIYAL 287
            |..:::.....|.:.:|     || :|:.|.. ...:|..:|...|.: |...|:...:||:...
Mouse   440 KGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSK-LYRAALETDENLLLCA 503

  Fly   288 PTSGGKTLVAEILMLRE----------LLCRERNVLFILPYVSIVQEKVSAMSPFAIDLDFIVEE 342
            ||..|||.||.:.||||          :...:..:::|.|..|:|||.|.:...........|.|
Mouse   504 PTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAE 568

  Fly   343 YTAGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDVQRPHEIGLVVVDELHLIGEKGRGATLEA 407
            .|.....|  :.......:.:.:.||..::.....:......:.|:|:||:||:.: .||..|||
Mouse   569 LTGDHQLC--KEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIVLDEIHLLHD-DRGPVLEA 630

  Fly   408 FLTK----VMFLNANIQIVGMSATIGNLSEISSFLNAD------VYTRGFRPVELKEYIKCGPDL 462
            .:.:    :.....:::::|:|||:.|..::::||..|      .:...||||.|:
Mouse   631 LVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLE--------- 686

  Fly   463 LEINSAGQTLEEIFVPSRSVEYNYSEAVKRADPDHLAGLISECAPEHC----CLVFCPSRKNCEN 523
                   ||.         |.....:|:||.  ..:..::.|...||.    .|||..|||....
Mouse   687 -------QTY---------VGITEKKAIKRF--QIMNEIVYEKIMEHAGKNQVLVFVHSRKETGK 733

  Fly   524 VALLLSRIVPKHK---FFEHRRSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKY 585
            .|..:..:..:..   .|....|...:::....:.|..|.  |...||||.|.||:|:|..:|..
Mouse   734 TARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLE--LKDLLPYGFAIHHAGMTRVDRTL 796

  Fly   586 IETAYRFGVVTVICCTSTLAAGVNLPAKRVIIR-----APYVGQ-EFLTLCKYKQMVGRAGRAGL 644
            :|..:....:.|:..|:|||.||||||..|||:     :|..|: ..|......||:|||||...
Mouse   797 VEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQY 861

  Fly   645 GEAGESILIAQSKDNLLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVN 709
            ...||.|||...      |::.:     .||.|  |:.:.::|.::|           .|..::|
Mouse   862 DTKGEGILITSH------GELQY-----YLSLL--NQQLPIESQMVS-----------KLPDMLN 902

  Fly   710 STLLSVQAKSLEVAVN-----EIVLRILRE---------------MFKNKVLQLAEPQAKSKINS 754
            :.::....::.:.|||     .:.:|:||.               :...:.|.|....|.
Mouse   903 AEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAAL----- 962

  Fly   755 SDIITSQDVSQANRPAGDRRLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLILT 819
              ::...::.:.::..|:          |::|.:||.|    ..|...|    :..|...||
Mouse   963 --MLDKNNLVKYDKKTGN----------FQVTELGRIA----SHYYITN----DTVQTYNQL--- 1004

  Fly   820 NYLHLLYLVVCFNSNERGDELFPADASI-LFGVYTSLPLDSQAMFKQLGFTEAHAARLFKTQSVQ 883
                                |.|..:.| ||.|::   |.|:                ||..:|:
Mouse  1005 --------------------LKPTLSEIELFRVFS---LSSE----------------FKNITVR 1030

  Fly   884 GPLSLQLNRLYKVLILADILNLLPIP------SVASKYNVERGTLQHLISQ-------------- 928
            ....|:|.:|         |..:|||      ..::|.||   .||..|||
Mouse  1031 EEEKLELQKL---------LERVPIPVKESIEEPSAKINV---LLQAFISQLKLEGFALMADMVY 1083

  Fly   929 STAAASAIVRLCEE--LEEFWCY---------KPLFERILHKMDRCGTFELEPLMELPAVKINRA 982
            .|.:|..::|...|  |...|..         |.:.:|:...|  |...:...|.|....||.:.
Mouse  1084 VTQSAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQSM--CPLRQFRKLPEEVVKKIEKK 1146

  Fly   983 ----RQLYAAGFQTIGDIARV--------RPSHLVQSLE 1009
                .:||......||::.|:        :..||...||
Mouse  1147 NFPFERLYDLNHNEIGELIRMPKMGKTIHKYVHLFPKLE 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	55/223 (25%)
		BRR2	255..828	CDD:440817	145/626 (23%)
Snrnp200	NP_796188.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..81
		Helicase_PWI	254..363	CDD:436309	23/129 (18%)
		Interaction with C9orf78 and WBP4. /evidence=ECO:0000250|UniProtKB:O75643	395..2129		215/949 (23%)
		BRR2	462..1017	CDD:440817	154/659 (23%)
		DEXHc_Brr2_1	464..677	CDD:350777	52/216 (24%)
		DEAH box	615..618		2/2 (100%)
		Sec63	982..1285	CDD:460740	58/268 (22%)
		Interaction with TSSC4. /evidence=ECO:0000250|UniProtKB:O75643	1282..2136
		BRR2	1309..1849	CDD:440817
		DEXHc_Brr2_2	1325..1515	CDD:350779
		DEAH box	1454..1457
		SEC63	1809..2125	CDD:214744