DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus301 and helq-1

DIOPT Version :9

Sequence 1:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster
Sequence 2:	NP_001022911.1	Gene:	helq-1 / 175210	WormBaseID:	WBGene00021905	Length:	923	Species:	Caenorhabditis elegans

Alignment Length:	968	Identity:	323/968 - (33%)
Similarity:	502/968 - (51%)	Gaps:	135/968 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 AEMEDIFHGADDFSDPMVQNTQLFLDAMTFKKPKTPEKLLAPLKDDSMSFISKSV---------- 193
            ||:|:     |.|| |:.:.::|       :.|:|..:.:.|||..|....|.|.
Worm    12 AEIEE-----DPFS-PIPKFSRL-------RTPRTSREYVCPLKSTSPQSPSSSTENEPPPVSVT 63

  Fly   194 -----IEGLVQGT-----QYVTCEELKNQSLLDPVN-WETQAFADFEKNNQDIDKF--------- 238
                 ...|.:.|     |.:....||..||....: :.|.|:.:.|..|.| |.|
Worm    64 SPPARKRALEESTVTPIQQKIGPPVLKRSSLSKLADGFRTAAYLNNESENDD-DPFGLSFRNEQV 127

  Fly   239 -------------------PSKGEFYGLPDKVKKMILEHKGINSLYEWQDECLNLPAIRQRKNLI 284
                               |||    .||::..:|..:.|.::..|:||.|||:...:...:|.|
Worm   128 LMSKCAPAPEKRPETLTLDPSK----CLPERDMEMYRKIKKLDKFYDWQQECLSDKRLLDGENCI 188

  Fly   285 YALPTSGGKTLVAEILMLRELLCRERNVLFILPYVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGK 349
            .:|||..||||:||:|||||.:.|:||.:.:||||:|||||:||::||.......:|||.:.||:
Worm   189 LSLPTGAGKTLIAEVLMLREAIVRKRNAILVLPYVAIVQEKISALAPFEDAFGINIEEYASNKGR 253

  Fly   350 CPPQPRRKRRSLFIASIEKGAVLMDSLIDVQRPHEIGLVVVDELHLIGEKGRGATLEAFLTKVMF 414
            .||..||||.|:::|:|||..:|::|||...:...:|:|||||||:||:.||||.||..|.|.::
Worm   254 FPPIKRRKRVSVYVATIEKANMLINSLITQGQLDRVGMVVVDELHMIGDGGRGAILEQLLAKFLY 318

  Fly   415 LNANIQIVGMSATIGNLSEISSFLNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPS 479
            .... ||||||||:.|:.::...|.|.||:..||||||.|::|.|..:.:::..|.......:|:
Worm   319 KGTG-QIVGMSATLPNIDDLKFALRAFVYSTNFRPVELTEFVKIGQTMHQVSENGDLNPAGDLPT 382

  Fly   480 RSVEYNYSEAVKRADPDHLAGLISECAPEHCCLVFCPSRKNCENVALLLSRIVPKH--------- 535
            .:        :|..|||.:..|:::..|::..::|||::|||||||:|:::.:|.|
Worm   383 NN--------LKSTDPDGICQLLAKLIPKNSAVIFCPNKKNCENVAVLIAKTLPAHIRQAKRAES 439

  Fly   536 -KFFEHRRSEKLD-LMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVI 598
             .|.:...|:..| .|||:.|.| |||         |:||||||||.||||.:|.|:..|::.|:
Worm   440 DAFLQSYLSDNDDERMDAVLKQC-ILS---------GVAYHHSGLTQDERKCVEAAFMEGLIYVV 494

  Fly   599 CCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGESI-LIAQSKDNLLV 662
            |.|||||||||||.:||||:||.||:|.|...:|.||.|||||||....|:.| :|...::....
Worm   495 CATSTLAAGVNLPVRRVIIKAPMVGRERLGKAQYLQMAGRAGRAGFDTKGDCITIIKAGEEERWF 559

  Fly   663 GQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLEVAVNEI 727
            .:||.|.:.:.:|||...|::|  |.||..|.|.|||...::...|..:|...|    |...|
Worm   560 REMLKSDIPRCMSSLSSEESMG--SFILDCVVLKLAENIEEIMTAVRYSLFYAQ----ESPEN-- 616

  Fly   728 VLRILREMFKNKVLQLAEPQAKSKINSSDIIT----SQDV-SQANRPAGDRRLLIGQSTPFKLTN 787
                :|::.::.|.:|.|..         .||    .||| |:.:..|.....:.|:.:|   ::
Worm   617 ----IRKLVESSVKRLEEHY---------FITIEPLEQDVASEPSAQASSIPRVPGKISP---SD 665

  Fly   788 IGRAAFKAGIDYKRANAIHKEL-KQAQQQLILTNYLHLLYLVVCFNSNERGDELFPADASILFGV 851
            :|.|.|.||.|...|..:|.:| ....|.:|..::.|||:::..:      :::...:..:...:
Worm   666 LGNAVFNAGFDPDEATRLHADLVSSLNQGVIFASHFHLLFIITPY------EQVCNINWDLFLLM 724

  Fly   852 YTSLPLDSQAMFKQLGFTEAHAARLFKTQSVQGPLSLQLNRLYKVLILADILNLLPIPSVASKYN 916
            |.:||...:.:..:.|..|........|: |.........|||..|:|..|.|..|:.:||.::.
Worm   725 YNALPSSERKLLAECGLEEKFILEAIITR-VDLTAGTPRMRLYIALMLQKIWNHEPMYTVAERFG 788

  Fly   917 VERGTLQHLISQSTAAASAIVRLCEELEEFWCYKPLFERILHKMDRCGTFELEPLMELPAVKINR 981
            ||:|.||..:..|.:.|::|.:..|::...|..:.|...::.::......||.|||.:..:|..|
Worm   789 VEKGWLQATLQSSISQAASIAKFSEKITTMWPLRKLLPELVQRLSEAAQPELLPLMTVDGIKKAR 853

  Fly   982 ARQLYAAGFQTIGDIARVRPSHLVQSLEHMPLRVATEIVSAAKIILMKKLDHLEEETE 1039
            |..|:.||::|:|.|||..|..|||.|..:.:..|..|:::|:::|..::|...||.:
Worm   854 AAILFKAGYKTVGMIARANPLKLVQELGTIRMAQANSIIASARMVLRDQVDEKMEELD 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	BRR2	247..998	CDD:224125	276/768 (36%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	94/201 (47%)
helq-1	NP_001022911.1	BRR2	134..896	CDD:224125	288/815 (35%)
helq-1	NP_001022911.1	DEXHc_POLQ-like	151..352	CDD:350784	94/201 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163654
Domainoid	1	1.000	155	1.000	Domainoid score	I2600
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14667
Inparanoid	1	1.050	460	1.000	Inparanoid score	I875
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56135
OrthoDB	1	1.010	-	-		D103838at33208
OrthoFinder	1	1.000	-	-		FOG0001214
OrthoInspector	1	1.000	-	-		oto18648
orthoMCL	1	0.900	-	-		OOG6_101025
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3338
SonicParanoid	1	1.000	-	-		X3974
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940