Protein Alignment mus301 and DNApol-theta

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: XP_564726.4
• Gene: DNApol-theta / 1269701
• VectorBaseID: AGAMI1_010726
• Length: 1997
• Species: Anopheles gambiae
• Alignment Length: 1112
• Identity: 312/1112 - (28%)
• Similarity: 497/1112 - (44%)
• Gaps: 201/1112 - (18%)

  Fly    37 EGEDDDSFFS-NAHLEDLLDGRKEELFGTQATTSTNKMTQSGSDDGLGLFADTSFPSAQSVPPNS 100
            |.|::.||.: ..|.:..||..::.:   |...:..|||:|    .|.:|::|.|..|.:..| :
Mosquito   203 EKEEEGSFHTLFDHSDFTLDKEQQTV---QYPEAEAKMTES----ELEIFSETLFDRAITAEP-A 259

  Fly   101 ASKPDEASAPTDKHQIDLADEENA---DKLFKKINLNDLSIAEMEDIFHGA----------DDFS 152
            ..:..|||...:..::|.|||:.|   :.:.....|...|||..:...|..          |||.
Mosquito   260 MDELLEASDFVESLRVDSADEDVALDIENVTFSQPLASASIALAQTQSHDVSERRSKHTEMDDFI 324

  Fly   153 DPMVQNTQLFLDAMTFKKPKTPEKLLAPLKDDSMSFISKSVIEGLVQGT---------------- 201
            :..:.|:.|          :.|  :.|.|.|..:....:|  .||..|:
Mosquito   325 ESEMANSVL----------RMP--VDASLADTVVGRDGES--SGLFSGSLLNHSTKPETAKRPPP 375

  Fly   202 QYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKGEFYGLPDKVKKMILEHKGINSLYE 266
            ..::.:|.|:..||  .||                         |||..|.....: |||..|:.
Mosquito   376 TSMSLDETKDLRLL--ANW-------------------------GLPSTVTSEYAK-KGIVQLFP 412

  Fly   267 WQDECLN-LPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILPYVSIVQEKVSAMS 330
            ||.|||: ...:.:.|||||:.|||.|||||:|.|:.:.:..|:...:.|||:|::.:||:..:.
Mosquito   413 WQVECLSRKEVLLEGKNLIYSAPTSAGKTLVSEFLLAKTVTERKLKAMLILPFVAVAREKMLYLK 477

  Fly   331 PFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDVQRPHEIGLVVVDELHL 395
            .........||.:..|   ..|....:...|.:.:|||...:::.|::......:|||||||.||
Mosquito   478 DLLEPGGMRVEGFYGG---YHPPGGFESVDLAVCTIEKANSIVNRLLEQSALTTLGLVVVDEAHL 539

  Fly   396 IGEKGRGATLEAFLTKVMFLNA----NIQIVGMSATIGNLSEISSFLNADVYTRGFRPVELKEYI 456
            |.:.|||..||..|||:.|:.|    .||||.||||:.|:..::.:|.||:|...|||:.|.|.:
Mosquito   540 ISDPGRGYILELLLTKIRFVAARCEHRIQIVCMSATLPNIDLLARWLEADLYHTDFRPIALVEML 604

  Fly   457 KCGPDLLEINSAGQ-------TLEEIFVPSRSVEYNYSEAVKRADPDHLAGLISECAPEHCC-LV 513
            |.|..:  .:::|:       ||....||.              |.||:|.|..|...:.|. :|
Mosquito   605 KVGNTI--YSASGEAIRYLKGTLHGYTVPK--------------DADHVALLCLETILDGCAVIV 653

  Fly   514 FCPSRKNCENVALLLSRIV-----PKHKFFEHRR--SEKLD-------LMDALDKMCGILSPVLA 564
            ||||:..||.:|:.|:..:     ..|...|.||  .|:||       |:...:...| |..||.
Mosquito   654 FCPSKDWCEQLAISLASTLHTLRKENHPHDELRRRLREQLDGERQEEVLLQLRNCPAG-LDSVLE 717

  Fly   565 KTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTL 629
            ||:.||:|:||:|||||||..||.::|.|.:.:|..||||::||||||:|||:|.|..|.:.::.
Mosquito   718 KTVRYGVAFHHAGLTTDERDIIEGSFRDGALRIIVATSTLSSGVNLPARRVIVRTPKFGGKPMSS 782

  Fly   630 CKYKQMVGRAGRAGLGEAGESILIAQSKDNLLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVG 694
            ..||||:|||||.|....||||||....:..:..:::.:.:....|.||......|:..||.::.
Mosquito   783 LTYKQMIGRAGRTGRDTLGESILICTPAEEKIGRELIGAELPPVRSCLDSENYAHLKRAILEIIA 847

  Fly   695 LNLAECRRDLNRLVNSTLLSVQAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSDIIT 759
            ...|...::|...||:||.|.: :.....||:.:||  .:...:|.|...|.:..::  .:|.|.
Mosquito   848 SGSATTTQELETFVNATLYSCE-RDYRFEVNDQLLR--PKASSSKKLPTGEEEDDNE--ETDPIV 907

  Fly   760 S--------------------QDVSQANRPAGDRRLLIGQSTPFKLTNIGRAAFKAGIDYKRANA 804
            |                    :|.|....|...:|      |....|.:|:|...|.:..|....
Mosquito   908 SCISFLLEYEFIRCLQQDIVEEDGSTTATPKSTKR------TVLSATRLGQACLSASLPPKDGFL 966

  Fly   805 IHKELKQAQQQLILTNYLHLLYLVVCFNSNERGDELFPADASILFGVYTSLPLDSQAMFKQLGFT 869
            :..||::|:|..:|.:.||.:|||..::...:..::   |......::..||..|:.:.:.:|..
Mosquito   967 LFSELQRARQCFVLESELHAIYLVTPYSVAYQWQQI---DWMDFLDLWEKLPSASKRVGELVGVK 1028

  Fly   870 EAHAARLFKTQSVQGPLSLQLN-RLYKVLILADILNLLPIPSVASKYNVERGTLQHLISQSTAAA 933
            |:...|..:..:.....:||:: |.|..|.|.|::|.:|:.:||.::...||.||.|...|:..|
Mosquito  1029 ESFMVRAMRGAANLDYRTLQIHKRFYTALALLDLVNEVPLCTVARRFKCCRGLLQSLQQVSSTFA 1093

  Fly   934 SAIVRLCEELEEFWCYKPLF-----ERILHKMDRCGTFELEPLMELPAVKINRARQLYAAGFQTI 993
            ..:...|..|.  |....|.     ||:...:    ..||..||.:|::...|||.|:..|...:
Mosquito  1094 GIVTSFCASLN--WTLLQLLVAQFRERLFFGV----AHELLDLMRIPSLNGQRARLLHDGGITGL 1152

  Fly   994 GDIA--------------------RVRPSHLVQSLE--------HMPLRVATEIVSAAKIILMKK 1030
            ..:|                    |||.:......|        ::..|....:..||::::.:.
Mosquito  1153 VQLANSDRLAVETILHHRTSFEAERVRENENEYDAERRKRLRNLYLTGRAGVTVEEAARLLIQEA 1217

  Fly  1031 LDHLEEE 1037
            ..:|:.|
Mosquito  1218 RTYLQLE 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	77/206 (37%)
		BRR2	255..828	CDD:440817	205/619 (33%)
DNApol-theta	XP_564726.4	None