DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus301 and HELQ

DIOPT Version :9

Sequence 1:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster
Sequence 2:	NP_598375.3	Gene:	HELQ / 113510	HGNCID:	18536	Length:	1101	Species:	Homo sapiens

Alignment Length:	1054	Identity:	394/1054 - (37%)
Similarity:	594/1054 - (56%)	Gaps:	127/1054 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TENLFWPEGEDDDSFFSN--AHLEDLLDGRKEEL-------------FGTQATTSTNKMTQSGS- 78
            |||.|..:.:|.:..:..  .|.:...|...|.|             .|......|:|.|::.|
Human   115 TENSFIAQVDDLEQKYMQLPEHKKHATDFATENLCSESIKNKLSITTIGNLTELQTDKHTENQSG 179

  Fly    79 ------DDGLGLFADTSFPSAQSV----PPNSASKPDEASAPTDKHQIDLADEENADKLFKKINL 133
                  :.|..|..|.  ||:|::    ..||::              ||.|....::.:|..:.
Human   180 YEGVTIEPGADLLYDV--PSSQAIYFENLQNSSN--------------DLGDHSMKERDWKSSSH 228

  Fly   134 NDLSIAEMEDIFHGADDFSDPMVQNTQLFLDAMTFKKPKTPEKLLAPLKDDSMSFISKSVIEGL- 197
            |.::    |::.|..                   .::|:..::..:.::..|.....||:.:.|
Human   229 NTVN----EELPHNC-------------------IEQPQQNDESSSKVRTSSDMNRRKSIKDHLK 270

  Fly   198 --------VQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKGEFYGLPDKVKKM 254
                    .|...:...::||:..|.:.:|   .|....|.::.|:      |.||.||.||:.:
Human   271 NAMTGNAKAQTPIFSRSKQLKDTLLSEEIN---VAKKTVESSSNDL------GPFYSLPSKVRDL 326

  Fly   255 ILEHKGINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILPYV 319
            ..:.|||..|||||..||.|.::::||||||:||||||||||||||||:||||..::||.|||||
Human   327 YAQFKGIEKLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYV 391

  Fly   320 SIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDVQRPHE 384
            :|||||:|.:|.|.|:|.|.||||...||:.||..||:::||:||:||||..|::|||:..|...
Human   392 AIVQEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRIDS 456

  Fly   385 IGLVVVDELHLIGEKGRGATLEAFLTKVMFLNANIQIVGMSATIGNLSEISSFLNADVYTRGFRP 449
            :|||||||||:|||..||||||..|.|:::.:...||:|||||:.|:.::..||.|:.||..|||
Human   457 LGLVVVDELHMIGEGSRGATLEMTLAKILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRP 521

  Fly   450 VELKEYIKCGPDLLEINSA---GQTLEEIFVPSRSVEYNYSEAVKRADPDHLAGLISECAPEHCC 511
            ||||||:|....:.|::|.   |.|.      ||.:.|.||:.:|:.|||||..|::|..|.:.|
Human   522 VELKEYLKINDTIYEVDSKAENGMTF------SRLLNYKYSDTLKKMDPDHLVALVTEVIPNYSC 580

  Fly   512 LVFCPSRKNCENVALLLSRIVPKHKFFEHRRSEKLDLMDALDKM-CGILSPVLAKTLPYGIAYHH 575
            ||||||:|||||||.::.:.:.| ::.:|:..||.:::..|..: .|.|.|||.:|:|:|:||||
Human   581 LVFCPSKKNCENVAEMICKFLSK-EYLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHH 644

  Fly   576 SGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAG 640
            ||||:||||.:|.||..||:.:..|||||||||||||:|||:|||||.:|||...:||||:||||
Human   645 SGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIGRAG 709

  Fly   641 RAGLGEAGESILIAQSKDNLLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLN 705
            |||:...||||||.|.||...|.:::..|::...|.|.|....|:|:|.||::||.:|....|:.
Human   710 RAGIDTIGESILILQEKDKQQVLELITKPLENCYSHLVQEFTKGIQTLFLSLIGLKIATNLDDIY 774

  Fly   706 RLVNSTLLSVQAKSL--EVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSDIITSQDVSQANR 768
            ..:|.|...||.|.|  |.::.||.:..||.:.:..:||           ...|..|::..|.|
Human   775 HFMNGTFFGVQQKVLLKEKSLWEITVESLRYLTEKGLLQ-----------KDTIYKSEEEVQYN- 827

  Fly   769 PAGDRRLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLILTNYLHLLYLVVCFNS 833
                          |.:|.:|||:||..||....:.::::||:..:.|:|.:.|||:||...::.
Human   828 --------------FHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPYDL 878

  Fly   834 NERGDELFPADASILFGVYTSLPLDSQAMFKQLGFTEAHAARLFKTQSVQGPLSLQ-LNRLYKVL 897
            ..:.:    .|..|.|..::.|....|.:...||.:|:...:....|::...:... :||||...
Human   879 VSQCN----PDWMIYFRQFSQLSPAEQNVAAILGVSESFIGKKASGQAIGKKVDKNVVNRLYLSF 939

  Fly   898 ILADILNLLPIPSVASKYNVERGTLQHLISQSTAAASAIVRLCEELEEFWCYKPLFERILHKMDR 962
            :|..:|....|.:|:.|:|:.||.:|:|::.:.:.:|.::..||||||||.|:.|...:..|:..
Human   940 VLYTLLKETNIWTVSEKFNMPRGYIQNLLTGTASFSSCVLHFCEELEEFWVYRALLVELTKKLTY 1004

  Fly   963 CGTFELEPLMELPAVKINRARQLYAAGFQTIGDIARVRPSHLVQSLEHMPLRVATEIVSAAKIIL 1027
            |...||.||||:..|...||:|||:||::::..:|...|..||::::|:..|.|.:|||:||::|
Human  1005 CVKAELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDHLSRRQAKQIVSSAKMLL 1069

  Fly  1028 MKKLDHLEEETENL 1041
            .:|.:.|:||.|.|
Human  1070 HEKAEALQEEVEEL 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	BRR2	247..998	CDD:224125	330/757 (44%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	116/201 (58%)
HELQ	NP_598375.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..261		9/71 (13%)
		PRK02362	318..1066	CDD:235032	340/784 (43%)
		DEXHc_POLQ-like	319..521	CDD:350784	116/201 (58%)
		DEAH box	463..466		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155069
Domainoid	1	1.000	195	1.000	Domainoid score	I3165
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14667
Inparanoid	1	1.050	643	1.000	Inparanoid score	I808
Isobase	1	0.950	-	0	Normalized mean entropy	S3723
OMA	1	1.010	-	-		QHG56135
OrthoDB	1	1.010	-	-		D103838at33208
OrthoFinder	1	1.000	-	-		FOG0001214
OrthoInspector	1	1.000	-	-		oto91431
orthoMCL	1	0.900	-	-		OOG6_101025
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3338
SonicParanoid	1	1.000	-	-		X3974
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750