Protein Alignment mus301 and ASCC3

DIOPT Version :10

• Sequence 1: NP_648178.1
• Gene: mus301 / 38905
• FlyBaseID: FBgn0002899
• Length: 1051
• Species: Drosophila melanogaster
• Sequence 2: XP_011533696.1
• Gene: ASCC3 / 10973
• HGNCID: 18697
• Length: 2207
• Species: Homo sapiens
• Alignment Length: 1096
• Identity: 224/1096 - (20%)
• Similarity: 409/1096 - (37%)
• Gaps: 313/1096 - (28%)

  Fly    10 KRSLDLSEESTSESHAKRQCTENL----------FWPEGEDDDSFFSNAHL---------EDLL- 54
            ::::.|..:.....|.:..||..|          .|.|.|.    :.|:.|         |||.
Human   194 QKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEK----YLNSTLKEMTEVPRVEDLCC 254

  Fly    55 ------------DGRKEELF---GTQATTSTNKMTQSG---SDDGLGLFADTSFPSAQSVPPNSA 101
                        |..::|||   |.:......|:.|:.   .|..|....|..|   |::..|..
Human   255 TLYDMLASIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRF---QALQDNCK 316

  Fly   102 SKPDEASAPTDKHQIDLADEENADKLFKKINLNDLSIAEME-------DIFHGADDFSDP---MV 156
            ....|.:.|....|:.:..|:. .:|.|:....:..||..|       ::..|...| ||   .:
Human   317 KILGENAKPNYGCQVTIQSEQE-KQLMKQYRREEKRIARREKKAGEDLEVSEGLMCF-DPKELRI 379

  Fly   157 QNTQLFLDA-----MTFKKPKTPEKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCE--ELKNQSL 214
            |..|..|:|     ::.::....||:..|...||.:...|:  ...:.|.:.:..|  :.:|..|
Human   380 QREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKT--SAFIAGAKMILPEGIQRENNKL 442

  Fly   215 LDPVN--WETQAFADFEKNN---QDIDKFPSKGE--FYGLP--DKVKKMILEHKGINSLYEWQDE 270
            .:.|.  :.......||:..   ||:|:.   |:  |.|:.  ::::.::.|
Human   443 YEEVRIPYSEPMPLSFEEKPVYIQDLDEI---GQLAFKGMKRLNRIQSIVFE------------- 491

  Fly   271 CLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRE---------LLCRERNVLFILPYVSIVQEKV 326
                .|....:|::...||..|||.:|.:.:|.|         :...|..::::.|..::..|..
Human   492 ----TAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMT 552

  Fly   327 SAMSPFAIDLDFIVEEYTA----GKGKCPPQPRRKRRSLFIASIEK-GAVLMDSLIDVQRPHEIG 386
            ...|.....|..||:|.|.    .|.:.      .|..:.:.:.|| ..|...|:.||.....:.
Human   553 DYFSRRLEPLGIIVKELTGDMQLSKSEI------LRTQMLVTTPEKWDVVTRKSVGDVALSQIVR 611

  Fly   387 LVVVDELHLIGEKGRGATLEAF----LTKVMFLNANIQIVGMSATIGNLSEISSFLNADVY---- 443
            |:::||:||:.| .||..||:.    |.:|....:.|:|:|:|||:.|..::::||:.:.|
Human   612 LLILDEVHLLHE-DRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLF 675

  Fly   444 --TRGFRPVELKEY---IKCGPDLLEINSAGQTLEEIFVPSRSVEYNYSEAVKRADPDHLAGLIS 503
              ...||||.|.:.   |||...:.::|:..:...|          |..:.||       ||
Human   676 FFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYE----------NVLKQVK-------AG--- 720

  Fly   504 ECAPEHCCLVFCPSR--------------KNCENVALLLSR----IVPKHKFFEHRRSEKLDLMD 550
                 |..:||..:|              |||.::......    .|...|..:..|:::
Human   721 -----HQVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQ----- 775

  Fly   551 ALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRV 615
                        :.:..|.|.:.||:|:...:|..:|..:..|.:.|:.||:|||.||||||..|
Human   776 ------------VRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAV 828

  Fly   616 II---------RAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQ-----------SKDNL 660
            ||         |..:|.   |.:....|:.|||||....:.||.|:|..           ::.|.
Human   829 IIKGTQIYAAKRGSFVD---LGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNP 890

  Fly   661 LVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLEVAV- 724
            :..|.|.|..|    :|:...|:|..:.:...|            :.::.|.|.|:.::..:|.
Human   891 IESQFLESLAD----NLNAEIALGTVTNVEEAV------------KWISYTYLYVRMRANPLAYG 939

  Fly   725 ----------------NEIVLRILREMFKNKVLQLAEPQAKSKINSSD--------------IIT 759
                            .::|:.:.|::.|.::::..|  .....:|:|              |.|
Human   940 ISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEE--RTGYFSSTDLGRTASHYYIKYNTIET 1002

  Fly   760 SQDVSQANRPAGDRRLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLILTNYLHL 824
            ..::..|::..||...::.::..|....:                  :|.:..:...:|:|:
Human  1003 FNELFDAHKTEGDIFAIVSKAEEFDQIKV------------------REEEIEELDTLLSNF--- 1046

  Fly   825 LYLVVCFNSNERGDELFPADASILFGVYTSL-PLDSQAMFKQLGFTEAHAARLFKTQSVQGPLSL 888
                 |..|...|.|......:||...|.|. .:||.::.....:...:|||:     |:....:
Human  1047 -----CELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARI-----VRALFEI 1101

  Fly   889 QLNR-----LYKVLILADIL--------------NLLPIPSVASKYNVERGTLQHL 925
            .|.:     .|::|.|:.::              ::|| |.:.::...::.|:..|
Human  1102 ALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILP-PHILTRLEEKKLTVDKL 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	51/227 (22%)
		BRR2	255..828	CDD:440817	139/668 (21%)
ASCC3	XP_011533696.1	BRR2	465..1020	CDD:440817	141/644 (22%)
		DEXHc_ASCC3_1	481..678	CDD:350778	50/220 (23%)
		Sec63	983..1291	CDD:460740	34/206 (17%)
		DEXHc_ASCC3_2	1331..1519	CDD:350780
		BRR2	1332..1854	CDD:440817
		SEC63	1814..2183	CDD:214744