DRSC/TRiP Functional Genomics Resources

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Protein Alignment mus301 and POLQ

DIOPT Version :9

Sequence 1:NP_648178.1 Gene:mus301 / 38905 FlyBaseID:FBgn0002899 Length:1051 Species:Drosophila melanogaster
Sequence 2:NP_955452.3 Gene:POLQ / 10721 HGNCID:9186 Length:2590 Species:Homo sapiens


Alignment Length:934 Identity:283/934 - (30%)
Similarity:445/934 - (47%) Gaps:157/934 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 DDSMS--FISKSVIE---GLVQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDIDKFPSKG 242
            |.|.|  |:|.||:.   ||.:..:.....|.|            ....|:|:     ||.....
Human    26 DSSASPQFLSGSVLSPPPGLGRCLKAAAAGECK------------PTVPDYER-----DKLLLAN 73

  Fly   243 EFYGLPDKVKKMILE--HK-GINSLYEWQDECLNLPAIRQRKNLIYALPTSGGKTLVAEILMLRE 304
              :|||    |.:||  |. |:..::|||.|||.|..:.:.|||:|:.|||.|||||||:|:|:.
Human    74 --WGLP----KAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKR 132

  Fly   305 LLCRERNVLFILPYVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQPRRKRRSLFIA--SIE 367
            :|...:..|||||:||:.:||...:.....::...|:.|...     ..|.|...||.||  :||
Human   133 VLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGS-----TSPSRHFSSLDIAVCTIE 192

  Fly   368 KGAVLMDSLIDVQRPHEIGLVVVDELHLIGEKGRGATLEAFLTKVMFL----------------N 416
            :...|::.||:..:...:|:|||||||::|:..||..||..|||:.::                |
Human   193 RANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSN 257

  Fly   417 ANIQIVGMSATIGNLSEISSFLNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPSRS 481
            | :||||||||:.||..::|:|||::|...||||.|.|.:|.|..:.:   :...|...|.|...
Human   258 A-VQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYD---SSMKLVREFEPMLQ 318

  Fly   482 VEYNYSEAVKRADPDHLAGLISE-CAPEHCCLVFCPSRKNCENVALLLSRIVPKHKFF--EHR-- 541
            |         :.|.||:..|..| ....|..|:||||:|.||.:|.:::|     :|:  .|:  
Human   319 V---------KGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAR-----EFYNLHHQAE 369

  Fly   542 --------------RSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRF 592
                          :.|.|::||.|.::...|..||.||:|:|:|:||:|||.:||..||.|:|.
Human   370 GLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQ 434

  Fly   593 GVVTVICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQSK 657
            |::.|:..||||::||||||:|||||.|..|...|.:..||||||||||.|:...||||||.::.
Human   435 GLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNS 499

  Fly   658 DN-----LLVGQMLFSPMDKALSSLDQNEAVG--LQSLILSVVGLNLAECRRDLNRLVNSTLLSV 715
            :.     ||.|.:  .|:...|...:..|..|  :::::..:|| .:|...:|::.....|.|:.
Human   500 EKSKGIALLQGSL--KPVRSCLQRREGEEVTGSMIRAILEIIVG-GVASTSQDMHTYAACTFLAA 561

  Fly   716 QAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSDIITSQDVSQANRPAGDRRLLIGQS 780
            ..|..:..:......:.....:..|:.|.|         ::.|.|.:.|...           :.
Human   562 SMKEGKQGIQRNQESVQLGAIEACVMWLLE---------NEFIQSTEASDGT-----------EG 606

  Fly   781 TPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLILTNYLHLLYLVVCFNSNERGDELFPADA 845
            ..:..|::|.|...:.:.......|..:|::|.:..:|.|.||:||||.         .:|....
Human   607 KVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVT---------PMFEDWT 662

  Fly   846 SI----LFGVYTSLPLDSQAMFKQLGFTEAHAARLFK------TQSVQGPLSLQLNRLYKVLILA 900
            :|    .|.::..||...:.:.:.:|..|...||..|      |:.....:::. .|.:..|:|.
Human   663 TIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIH-KRFFTSLVLL 726

  Fly   901 DILNLLPIPSVASKYNVERGTLQHLISQSTAAASAIVRLCEELEEFWCYKPLFERILHKMDRCGT 965
            |:::.:|:..:..||...||.:|.|...:...|..|......|.  |   ...|.:|.:..:..|
Human   727 DLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLG--W---HNMELLLSQFQKRLT 786

  Fly   966 F----ELEPLMELPAVKINRARQLYAAGFQTIGDIARVRPSHLVQSLEHMPLRVATEIVSAAKII 1026
            |    ||..|:.:..:...|||.|||:||.|:.|:||   :::|:  ..:.|:.|....||.|.:
Human   787 FGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLAR---ANIVE--VEVILKNAVPFKSARKAV 846

  Fly  1027 LMKKLDHLEEETENLKDCLKTSDK 1050
              .:.:...||..|::....|..|
Human   847 --DEEEEAVEERRNMRTIWVTGRK 868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mus301NP_648178.1 BRR2 247..998 CDD:224125 254/811 (31%)
DEXHc_POLQ-like 247..449 CDD:350784 87/222 (39%)
POLQNP_955452.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33 3/6 (50%)
BRR2 76..829 CDD:224125 257/822 (31%)
DEAD 96..274 CDD:278688 72/183 (39%)
DEAH box 216..219 2/2 (100%)
HELICc 412..485 CDD:197757 43/72 (60%)
Interaction with RAD51. /evidence=ECO:0000269|PubMed:25642963 847..894 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1060
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1594..1622
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797
PolA 1900..2586 CDD:223820
DnaQ_like_exo 1900..2085 CDD:299142
DNA_pol_A_theta 2091..2585 CDD:176475
Loop 1. /evidence=ECO:0000269|PubMed:21050863 2142..2177
Loop 2. /evidence=ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:25643323 2257..2322
Loop 3. /evidence=ECO:0000269|PubMed:21050863 2491..2535
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0749
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D103838at33208
OrthoFinder 1 1.000 - - FOG0001214
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101025
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.720

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