DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus301 and polg

DIOPT Version :9

Sequence 1:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster
Sequence 2:	XP_001921130.3	Gene:	polg / 100150924	ZFINID:	ZDB-GENE-060303-1	Length:	1206	Species:	Danio rerio

Alignment Length:	901	Identity:	154/901 - (17%)
Similarity:	256/901 - (28%)	Gaps:	381/901 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KKRSLDLSE--ESTSESHAKRQCTENLFWPEG-------EDDDSFFSNAHLEDLLDGRKEELFGT 64
            ||::...:|  |:.::|.|       :.|||.       |:.||           |.|:|.|...
Zfish   473 KKKAKQEAEATEAANDSEA-------IDWPEDPGPPLEEEEGDS-----------DPRRELLQRL 519

  Fly    65 QATTST---------------NKMTQSGSDDGLGLFADTSFPSAQSVPPNSASKPDEASAPTDKH 114
            :.|.|.               .|:....|:      |:...|.|..:.......|.......|..
Zfish   520 KETVSCLPKRRQHLPAHPSWYRKLCVKMSE------AEDWSPGASLISLQMRITPKLMGLTWDGF 578

  Fly   115 QIDLADEENADKLF--KKINLNDLSIAEMEDIFHGADDFSDPMVQNTQL------FLDAMTFKKP 171
            .:...|:.....|.  ::.|| |:|           :|..:|:.....:      :.:....::|
Zfish   579 PLHYTDQHGWGYLVPGRRDNL-DIS-----------EDNEEPVCPYRAIESVYKEYCEQKGKEQP 631

  Fly   172 KTPEKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCEELKNQSLLDPVNWETQAFADFEKNNQDID 236
            |.|:   :|:.|:.|          |.....:.|.||:....:.|.....|.|
Zfish   632 KYPD---SPVSDELM----------LTDTAVWQTVEEVSRLEMFDDEALSTAA------------ 671

  Fly   237 KFPSKGEFYGLPDKVKKMILEHKGINSLYE-WQDEC-----------LNLPAIRQRKNLIYALPT 289
              |||        ::.|.      :||::: ...||           :|:|..     ..:.||.
Zfish   672 --PSK--------RITKK------VNSVFKSLNGECPYHHGNGPYNDVNIPGC-----WFFKLPH 715

  Fly   290 SGGKTLVAEILMLRELLCRERNVLFILPYVSIVQEKVSAMSPFAIDLDFIVEEYTAGKGKCPPQP 354
            ..|               .|.||                .|||:.|
Zfish   716 KDG---------------NENNV----------------GSPFSKD------------------- 730

  Fly   355 RRKRRSLFIASIEKGAVLMDSLIDVQRPHEIGLVVVDELHLIGEKGRGATLEAFLTKVMFLNANI 419
                   |::.:|.|.:                       ..|.:|..||....:.|::....|.
Zfish   731 -------FLSKMESGTL-----------------------QAGREGTNATRALEINKMISFWRNA 765

  Fly   420 QIVGMSATIGNLSEISSFLNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIF----VPSR 480
            |           ..|||.:     ....|..||...::...|..|....|..|.::.    |..|
Zfish   766 Q-----------KRISSQM-----VVWLRRAELPRSVRLHQDYDEEGQYGAILPQVIPAGTVTRR 814

  Fly   481 SVEYNY---SEAVK--------------------RADPDH----LAGLISEC--APEHCCLVFCP 516
            :||..:   |.|.|                    .||.|.    :|.::.|.  |..|.|..|
Zfish   815 AVEPTWLTASNARKDRVGSELKAMVQVPPAYHLVGADVDSQELWIAAMLGEAHFAGMHGCTAF-- 877

  Fly   517 SRKNCENVALLLSRIVPKHKFFEHRRSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTD 581
                             .....:.::|:..||........|| |...||...||..| .:|....
Zfish   878 -----------------GWMTLQGKKSQGTDLHSRTADAVGI-SREHAKVFNYGRIY-GAGQPFA 923

  Fly   582 ERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPYVGQEFLTLCKYKQMVGRA---GRAG 643
            ||..::..:|.        :...|||                       |.:||....   .|..
Zfish   924 ERLLMQFNHRL--------SQQEAAG-----------------------KARQMYALTKGLRRYH 957

  Fly   644 LGEAGESILIAQSKDNLLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLV 708
            |.|.||.:|           |.|...:::|     ::.::.||.|             |.::::.
Zfish   958 LSEEGEWLL-----------QKLNVNVERA-----EDGSISLQDL-------------RKISKVA 993

  Fly   709 NSTLLSVQAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSDIITSQDVSQANRPAGDR 773
            ..:......|...:....:..........||:                    :.::|::|||
Zfish   994 TQSTTRGSKKKWNLTAGRVWTDGTESYMFNKL--------------------ESIAQSDRPA--- 1035

  Fly   774 RLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQLIL----TNYLHLL 825
                   ||.....|.||.        ..:|:.:|...::...::    .:||||:
Zfish  1036 -------TPVLNCRISRAL--------EPSAVQEEFITSRVNWVVQSSAVDYLHLM 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus301	NP_648178.1	BRR2	247..998	CDD:224125	105/631 (17%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	30/213 (14%)
polg	XP_001921130.3	DnaQ_like_exo	<230..>266	CDD:299142
		DNA_pol_A	400..>442	CDD:295402
		eIF3_subunit	445..>521	CDD:285763	16/65 (25%)
		DNA_pol_gammaA	741..1167	CDD:176478	85/471 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900