DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7504 and HELZ

DIOPT Version :9

Sequence 1:NP_001137907.1 Gene:CG7504 / 38904 FlyBaseID:FBgn0035842 Length:1676 Species:Drosophila melanogaster
Sequence 2:XP_006722277.1 Gene:HELZ / 9931 HGNCID:16878 Length:1970 Species:Homo sapiens


Alignment Length:773 Identity:172/773 - (22%)
Similarity:280/773 - (36%) Gaps:231/773 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   986 SVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYK-INNKNTFSVSLI------- 1042
            |.|.:..|.||    .:..:..||:.....|:.:|.::    .|| |:|.:..|.|.|       
Human   437 SADQLFTQSVL----DKSLTKSNYQSRLHDLLYIEEIA----QYKEISNTSGASTSRILLQDTTN 493

  Fly  1043 --------------NVETQDMCYRLVTRV--------NSKPFGKFVLY------TLYCCGMLKET 1079
                          .|:.|.:...::|.|        |.:.||:|.|.      ||  .|.|..|
Human   494 VTRGFSCCSKLFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTL--AGRLVMT 556

  Fly  1080 FAN-----------LLELKFVSGNVFDLTFEILKQDISEEKLKN----------IKQLTARPVVD 1123
            ..|           |::.:.....|::.|.        |||.|.          .::|..||..|
Human   557 KVNAVYLLPVPKQKLVQTQGTKEKVYEATI--------EEKTKEYIFLRLSRECCEELNLRPDCD 613

  Fly  1124 SLRVELGALSAVHQLRSSPLCR------RILKPTQTVNEVSL-------PKQPFTFKGCHKLNEH 1175
            : :|||     ..||...|||.      ||........::|:       |.:.:..:...:||..
Human   614 T-QVEL-----QFQLNRLPLCEMHYALDRIKDNGVLFPDISMTPTIPWSPNRQWDEQLDPRLNAK 672

  Fly  1176 QENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHSNTAV 1240
            |:..||.....:...|.|  .||.||.||||:..:::.....|......    :||||.|||:|.
Human   673 QKEAVLAITTPLAIQLPP--VLIIGPYGTGKTFTLAQAVKHILQQQETS----RILICTHSNSAA 731

  Fly  1241 DHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQ 1305
            |..:           :|..|    ...|..:..:||  |..:|.....:.:..|..:.. ::...
Human   732 DLYI-----------KDYLH----PYVEAGNPQARP--LRVYFRNRWVKTVHPVVHQYC-LISSA 778

  Fly  1306 HNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICT 1370
            |                 ||:   |:.|||.                         :.:..::..
Human   779 H-----------------STF---QMPQKED-------------------------ILKHRVVVV 798

  Fly  1371 TLSSCVKLANYVD----FFDICIVDEATQCTEPWTLLPMRFGL--THMVLVGDMQQLPAVVLSKK 1429
            ||::...|.. :|    ||...::|||.|..|..|::|:....  |.:||.||..||...|.|:.
Human   799 TLNTSQYLCQ-LDLEPGFFTHILLDEAAQAMECETIMPLALATQNTRIVLAGDHMQLSPFVYSEF 862

  Fly  1430 AIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLI--N 1492
            |.:..|..|:.||:....      |..:...    ..|...||.|..|..:.::.|||.:|:  .
Human   863 ARERNLHVSLLDRLYEHY------PAEFPCR----ILLCENYRSHEAIINYTSELFYEGKLMASG 917

  Fly  1493 AECTARFASPLIPYCVINLKYTCDSNGAQNKSIS---NNEEARFVAKLLTEMDKHMP-----SKR 1549
            .:...:...||       ..:|......|.|:.:   ||.|...|.:.:.|:.:..|     ...
Human   918 KQPAHKDFYPL-------TFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDD 975

  Fly  1550 FSYGLISPYQNQCYALSQVIP----SHMNITPQTVDSYQGLEKDVIIISNARTR-GC-------- 1601
            .|.|:::||.:|.:.:...:.    |.:|:  :.|.:.||.:..|:.:|..||| .|        
Human   976 GSIGVVTPYADQVFRIRAELRKKRLSDVNV--ERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIK 1038

  Fly  1602 ---------------GFLTNYQRLNVALTRPRRCLVICGNFEDLKSV----EMWRNLL 1640
                           |||:||:.||.|:||.:..:.:.|:...|.|:    :.|...:
Human  1039 KKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPIALCSIGRCRKFWERFI 1096

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7504NP_001137907.1 FHA 4..96 CDD:238017
FHA <10..101 CDD:224630
AAA_11 1171..1428 CDD:289831 61/262 (23%)
AAA_19 1194..1251 CDD:289986 18/56 (32%)
YtxH <1293..1347 CDD:295162 8/53 (15%)
AAA_12 1435..1626 CDD:289832 51/228 (22%)
HELZXP_006722277.1 zf-CCCH 181..205 CDD:279036
AAA_11 669..861 CDD:289831 61/261 (23%)
P-loop_NTPase 669..>766 CDD:304359 32/119 (27%)
DNA2 <785..1099 CDD:224037 81/357 (23%)
UvrD_C_2 868..1079 CDD:304668 52/229 (23%)
PHA03160 <1656..1815 CDD:165431
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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