DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Znfx1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_001028368.2	Gene:	Znfx1 / 98999	MGIID:	2138982	Length:	1909	Species:	Mus musculus

Alignment Length:	1306	Identity:	248/1306 - (18%)
Similarity:	432/1306 - (33%)	Gaps:	495/1306 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   773 ECRREALKKLSEKPKENSHRSTTN-----KRKNPTSVPTVQNTNRGGFLTKGVDGPAPKLAKTDN 832
            |.||..|:.....|..| ||...:     :.:|.|:.|..  ||..|...:..:.|||...:.:.
Mouse     2 EDRRPHLEARPRNPPAN-HRGPMDGELPPRARNQTNNPAA--TNHAGRHLRASNHPAPFRQREER 63

  Fly   833 AKPPPKKPVPKQPPAIETFSQQLQAADKAVLHPQPQCSRPVERK-EAELARNQR-TCNKVTFAEM 895
            .:...:.|...:.      :|:...:|:|  ..|.|......|: :.:..|:.| ..:..||.:.
Mouse    64 FRAMGRNPHQGRR------NQEGHTSDEA--RDQRQSQNDTRRRNDDQEGRSHRPPWSSDTFQQW 120

  Fly   896 ELYHQK----AEDSKK---------LQKK-------------LRKVHFNDDVKVHCIERV----- 929
            ....||    .:.:|:         |||:             |:::..:..:|...::.:
Mouse   121 HTPPQKPGEQPQQTKRLGYKFLESLLQKEPSEVAITLATSLGLKELLSHSSMKPSFLQLICQVLR 185

  Fly   930 KGASSKVQ-----------GRKECIKLRLSSY-----RERREWIRRENK---------------- 962
            |..||::.           ...:.:::.|.:|     .|....||.:..
Mouse   186 KACSSRIDRQSILHVLGILNNSKFLRVCLPAYVVGMITEPSPDIRNQYPEHISNIISLLQDLVSV 250

  Fly   963 -PVNDIRQHS-------------------------------RSILKWANQWLKHGS--------V 987
             |.:.:::.|                               ::|:|:..:..:.||        |
Mouse   251 FPASSMQETSMLISLLPTSLNALRASGVDIEEETEKNLEKVQAIIKYLQEKRRQGSLRVDTYTLV 315

  Fly   988 DAVAEQDV----LMPIPPEFDS----------------------------FKNYREIFV-PLMK- 1018
            .|.||.:|    .|||.|.::.                            |:..||.|| ||.:
Mouse   316 QAEAEGEVESYRAMPIYPTYNEVHLDEKPFLRPNIISGKYESTAVYLDTHFRLLREDFVRPLREG 380

  Fly  1019 -LELLSTIE----RDYKINN-KNTFSVSLINVETQDMC------YRLVTRVNSKPF-------GK 1064
             |:||.:.|    |..|.:: :..|...:|.    .||      |::  :.::||.       .|
Mouse   381 ILKLLQSFEDQCLRKRKFDDIRIYFDARIIT----PMCSASGIVYKV--QFDTKPLKLVRWQNSK 439

  Fly  1065 FVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTA--RPVVDSLRV 1127
            .:||....| |.|:.|...|.....:....||...|::...:|:.    :||.|  :|....|.|
Mouse   440 RLLYGSLVC-MSKDNFETFLFATVSNREHEDLCQGIVQLCFNEQS----QQLLADVQPSDSFLMV 499

  Fly  1128 ELGALSAVHQLRSSPLCRRILKPTQTVNEVSLPKQ----------------------PFT----- 1165
            |..|....:        |.:|:..|.|.|..:|.|                      .||
Mouse   500 ETTAYFEAY--------RHVLEGLQEVQEEDVPFQRNIVQCDSYVRNPRYLLMGGRYDFTPLMEN 556

  Fly  1166 -------FKGCHKLNEHQENI----------VLHTYQRIIDDLQPSLT----LIQGPPGTGKSRV 1209
                   .:|...|...:.|:          .|......::.||.:||    :|||||||||:.|
Mouse   557 PSAMRKSLRGAEALRHPRINVFDFGQWPSKEALKLDDSQMEALQFALTKELAIIQGPPGTGKTYV 621

  Fly  1210 ISELCLQTLYGNAA----KTLDRKILICAHSNTAVDHIV-GLLG----SVLRVMNRDQFHLLR-F 1264
            ..:: :|.|..|.:    .|....||:..::|.|:|..: |:.|    |::||..|....:|: |
Mouse   622 GLKI-VQALLTNKSVWQINTQTFPILVVCYTNHALDQFLEGIYGCQKTSIVRVGGRSNSEILKQF 685

  Fly  1265 GMHEKMSHYSRPFSLEAHFNKA----------KEQKLQ--------------------------- 1292
            .:.|..:......:|..|..:|          .|||||
Mouse   686 TLRELRNKREFRRTLPMHLRRAYMSIVTEMKESEQKLQEGAQTLECTMHGVLREQHLEKYISAQH 750

  Fly  1293 ----------------------------------------------------------------- 1292

Mouse   751 WESLMSGPVQDADWVCVQPSKHSMILEWLGLGVGSFTQSASPAGPENTAQAEGEEEEEGEEEGSL 815

  Fly  1293 --------------------------RVSKEN------AEIL----------------------- 1302
                                      |..:||      |::|
Mouse   816 IEIAEEADLIQADRVIEEEEVVRPRRRKKEENGTDQELAKMLLAMRLDQEVPGTTAGPEQATEEW 880

  Fly  1303 -------KKQHNDLKDEIQQLKEKT-------------NLTSTYLLQ----QLQQKEKKLQLISN 1343
                   ||....:|.|:::|...|             :|:|.:.|.    |:.|.:.:.:::|.
Mouse   881 ETQRGQKKKMKRRVKVELRKLNTMTKAEANGIQDVWQLDLSSRWQLYRLWLQMYQADTRRRILSY 945

  Fly  1344 QLS--------PPLTQREEFEISHMCVTRANIICTTLSSCVKLANYVDFFD--ICIVDEATQCTE 1398
            :..        ..|..:|:..|    :..|.::..|.:...|....:...:  |.||:||.:..|
Mouse   946 ERQYRTWAERMAELRLQEDLHI----LKDAEVVGMTTTGAAKYRQILQQVEPRIVIVEEAAEVLE 1006

  Fly  1399 PWTLLPMRFGLTHMVLVGDMQQL-PAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHT 1462
            ..|:..:.....|::|:||.||| |:..:...|.:|.|..|:|:|:.:              ::.
Mouse  1007 AHTIATLSKACQHLILIGDHQQLRPSANVYDLAKNFNLEVSLFERLVK--------------VNI 1057

  Fly  1463 KLFKLSTQYRMHPEICRWPNQYFYED-----------QLINAECTARFASPLIPYCVINLKYTCD 1516
            ...:|:.|:||.|||.|....:.|:|           |:........|.....|          :
Mouse  1058 PFVRLNYQHRMRPEIARLLTPHIYQDLENHPSVLKYEQIKGVSSNLFFVEHNFP----------E 1112

  Fly  1517 SNGAQNKSISNNEEARFVAKLLTEM--DKHMPSKRFSYGLISPYQNQCYALSQVIP--SHMNITP 1577
            ....:.||..|..||.||.:|...:  .:::||:   ..:::.|..|.:.|.:::|  :...|..
Mouse  1113 QEIQEGKSHQNQHEAHFVVELCQYLLCQEYLPSQ---ITILTTYTGQLFCLRKLMPVKTFAGIKV 1174

  Fly  1578 QTVDSYQGLEKDVIIISNARTR---GCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNL 1639
            ..||.|||.|.|:|::|..|:.   ..|||....|:.|||:|.::.:...||.:.|..|.:|..:
Mouse  1175 HVVDKYQGEENDIILLSLVRSNQEGKVGFLQIPNRICVALSRAKKGMYCIGNMQMLAKVPLWSRI 1239

  Fly  1640 LDDARK 1645
            :...|:
Mouse  1240 IHTLRE 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	81/472 (17%)
		AAA_19	1194..1251	CDD:289986	24/69 (35%)
		YtxH	<1293..1347	CDD:295162	17/114 (15%)
		AAA_12	1435..1626	CDD:289832	50/208 (24%)
Znfx1	NP_001028368.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..133		30/141 (21%)
		EEXXEc_NFX1	591..>674	CDD:350694	27/83 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..813		0/25 (0%)
		AAA_11	<897..1031	CDD:404072	29/137 (21%)
		EEXXEc_NFX1	<971..1066	CDD:350694	25/108 (23%)
		SF1_C_Upf1	1068..1244	CDD:350195	48/188 (26%)
		NF-X1-zinc-finger	1365..1410	CDD:100116
		Keratin_B2	1425..1563	CDD:366678
		NF-X1-zinc-finger	1453..1497	CDD:100116
		PRK03918	<1597..>1808	CDD:235175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810