DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and NAM7

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_013797.1	Gene:	NAM7 / 855104	SGDID:	S000004685	Length:	971	Species:	Saccharomyces cerevisiae

Alignment Length:	775	Identity:	203/775 - (26%)
Similarity:	325/775 - (41%)	Gaps:	194/775 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   951 RERREWIRRENKPVNDIRQHSRSI---------LKW-ANQWLKHGSVDAVAEQDVLMPIPPEFDS 1005
            |:...|:..:  |..:.:..:|.|         .|| :|:......:||..||:.:.|:...:..
Yeast   172 RQLLSWVAEQ--PTEEEKLKARLITPSQISKLEAKWRSNKDATINDIDAPEEQEAIPPLLLRYQD 234

  Fly  1006 FKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYT- 1069
            ...|:..:.||:||      |.||....|.:.::..|:|...       ..:|::....|.|.|
Yeast   235 AYEYQRSYGPLIKL------EADYDKQLKESQALEHISVSWS-------LALNNRHLASFTLSTF 286

  Fly  1070 --------------LYCCGM-----------------LKETFANLLELK---------FVSGNVF 1094
                          |:..||                 .::||.  ||||         ..:|...
Yeast   287 ESNELKVAIGDEMILWYSGMQHPDWEGRGYIVRLPNSFQDTFT--LELKPSKTPPPTHLTTGFTA 349

  Fly  1095 DLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKPTQTVN---E 1156
            :..::....|..::.||..       .:|...:            |..|..:|| ..|.|:   :
Yeast   350 EFIWKGTSYDRMQDALKKF-------AIDKKSI------------SGYLYYKIL-GHQVVDISFD 394

  Fly  1157 VSLPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGN 1221
            |.|||: |:.....:||..|.|.|.|..||       .|:||||||||||:     :...|:..:
Yeast   395 VPLPKE-FSIPNFAQLNSSQSNAVSHVLQR-------PLSLIQGPPGTGKT-----VTSATIVYH 446

  Fly  1222 AAKTLDRKILICAHSNTAVDHIVGLLGSV-LRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNK 1285
            .:|....:||:||.||.||||:...|..: |:|:              :::..||.....:..|.
Yeast   447 LSKIHKDRILVCAPSNVAVDHLAAKLRDLGLKVV--------------RLTAKSREDVESSVSNL 497

  Fly  1286 AKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLT 1350
            |....:.|.:|...:.|.|    ||||:.:|....  |..::                    .|.
Yeast   498 ALHNLVGRGAKGELKNLLK----LKDEVGELSASD--TKRFV--------------------KLV 536

  Fly  1351 QREEFEISHMCVTRANIICTTLSSCVKLAN-YVDF-FDICIVDEATQCTEPWTLLPMRFGLTHMV 1413
            ::.|.||    :.:|:::|.|   ||...: .:|. |...::||:||.:||..|:|:..|...::
Yeast   537 RKTEAEI----LNKADVVCCT---CVGAGDKRLDTKFRTVLIDESTQASEPECLIPIVKGAKQVI 594

  Fly  1414 LVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEIC 1478
            ||||.|||..|:|.:||.|.||..|:|:|:             ..|.|..: :|..||||:|.:.
Yeast   595 LVGDHQQLGPVILERKAADAGLKQSLFERL-------------ISLGHVPI-RLEVQYRMNPYLS 645

  Fly  1479 RWPNQYFYEDQLINAEC-------TARFASPL--IPYCVINLKYTCDSNGAQNKSISNNEEARFV 1534
            .:|:..|||..|.|...       .::|..|:  || .:....|..:...|...|..|..||...
Yeast   646 EFPSNMFYEGSLQNGVTIEQRTVPNSKFPWPIRGIP-MMFWANYGREEISANGTSFLNRIEAMNC 709

  Fly  1535 AKLLTEM--DKHMPSKRFSYGLISPYQNQ-CYALSQVIPS-------HMNITPQTVDSYQGLEKD 1589
            .:::|::  |...|.:   .|:|:||:.| .|.|..:..:       ::.:...:||::||.|||
Yeast   710 ERIITKLFRDGVKPEQ---IGVITPYEGQRAYILQYMQMNGSLDKDLYIKVEVASVDAFQGREKD 771

  Fly  1590 VIIISNART---RGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKR 1646
            .||:|..|.   :..|||.:.:||||.|||.:..|||.||...|....:|.:||...|::
Yeast   772 YIILSCVRANEQQAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREK 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	77/259 (30%)
		AAA_19	1194..1251	CDD:289986	24/57 (42%)
		YtxH	<1293..1347	CDD:295162	10/53 (19%)
		AAA_12	1435..1626	CDD:289832	62/212 (29%)
NAM7	NP_013797.1	DNA2	84..851	CDD:224037	203/775 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810