DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7504 and HELZ2

DIOPT Version :9

Sequence 1:NP_001137907.1 Gene:CG7504 / 38904 FlyBaseID:FBgn0035842 Length:1676 Species:Drosophila melanogaster
Sequence 2:XP_024307774.1 Gene:HELZ2 / 85441 HGNCID:30021 Length:2677 Species:Homo sapiens


Alignment Length:993 Identity:215/993 - (21%)
Similarity:353/993 - (35%) Gaps:334/993 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   837 PKKPVPKQPP-----AIET--FSQQLQAADKAVLHPQPQCSRPVERK-EA----ELARNQRT-CN 888
            |..|:|...|     |:||  :.|.|:..:   |...|:.:..::.| ||    ||.:.||: |.
Human  1807 PPLPLPGTVPDPHTLAVETALWKQLLELVE---LQRWPEAAALIQEKGEASQRRELVQVQRSHCG 1868

  Fly   889 KVTFAEMELYHQKAEDSKKLQKKLRKVHFNDDVKVH-------------------------CIER 928
            .  |.|:                .|::...|.::|.                         |:|.
Human  1869 H--FLEV----------------ARELGSGDTLQVQLGTSLQHGFLVPSPQLWTVAPGFSLCLEH 1915

  Fly   929 VKGASSKVQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILKWANQWLKHGSVDAVAEQ 993
            |:.......||         .||..|:..|       |:.:::   ..|........:..||||.
Human  1916 VERPGDCFSGR---------VYRAPRDRYR-------DVDEYA---CVWEPFCALESATGAVAEN 1961

  Fly   994 D--VLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRL--- 1053
            |  .|..:...:::.:      .|..:|:....:|..:...|     .:.||.....:|.||   
Human  1962 DSVTLQHLSVSWEASR------TPQGQLQGAFRLEAAFLEEN-----CADINFSCCYLCIRLEGL 2015

  Fly  1054 -VTRVNSKPFGKFVL----------YTLYCCGMLKE-----------------TFANLLELKFV- 1089
             ....:.:| |...|          ||....|..::                 .|.:.:.::.| 
Human  2016 PAPTASPRP-GPSSLGPGLNVDPGTYTWVAHGQTQDWDQERRADRQEAPRRVHLFVHHMGMEKVP 2079

  Fly  1090 -----SGNVFDLTFEILKQDI----SEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCR 1145
                 .|.:|  |.|:|.:.:    .||.::.:::  |.|:|.|:        |:.:....||||
Human  2080 EEVLRPGTLF--TVELLPKQLPDLRKEEAVRGLEE--ASPLVTSI--------ALGRPVPQPLCR 2132

  Fly  1146 -RILKPTQ--------------------TVNEVSLPKQPFTFK-GCHKLNEHQENIVLHTYQRII 1188
             |...|.|                    .:....|.:|.:... |.||||..| |:.:.      
Human  2133 GRSAPPLQLPLWPPAPPCMSAQGGCPLSVIPSRFLERQTYNIPGGRHKLNPSQ-NVAVR------ 2190

  Fly  1189 DDLQPSLTLIQGPPGTGKSRVISELCL--------QTLYGNAAKTLDRK----ILICAHSNTAVD 1241
            :.|:...|:|||||||||:.|...:..        |...|...:...|.    ||.|..||.:||
Human  2191 EALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVD 2255

  Fly  1242 HIVGLLGSVLRVM------------NRDQFHLLRFG----------------------MHEKMSH 1272
            .:.|||   ||.|            ...:|.:.|.|                      :|.::..
Human  2256 VLAGLL---LRRMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQ 2317

  Fly  1273 YSRPFSLEAHFNKAKEQKLQR---VSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQK 1334
            ...|:|.|.   ||.:.:|||   .|:|:....||                              
Human  2318 APNPYSSEI---KAFDTRLQRGELFSREDLVWYKK------------------------------ 2349

  Fly  1335 EKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLANYVDFFDI--CIVDEATQCT 1397
                         .|.:..:||:....|    |:||  .||...|: :...|:  .:||||...|
Human  2350 -------------VLWEARKFELDRHEV----ILCT--CSCAASAS-LKILDVRQILVDEAGMAT 2394

  Fly  1398 EPWTLLPM-RFGLTH-MVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLM 1460
            ||.||:|: :|.... :||:||.:||..||.:::..:.||..|:|:|                 .
Human  2395 EPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNLGLDRSLFER-----------------Y 2442

  Fly  1461 HTKLFKLSTQYRMHPEICRWPNQYFYEDQLINAECTARFASPL----IPYCVI----------NL 1511
            |.....|.||||||..||.:|:..||:.:|...:...|..|.|    ...|.:          :|
Human  2443 HEDAHMLDTQYRMHEGICAFPSVAFYKSKLKTWQGLRRPPSVLGHAGKESCPVIFGHVQGHERSL 2507

  Fly  1512 KYTCDSNGAQNKSISNNEEARFVAKLLTEMDKHMPSKRFSYGLISPYQNQCYALSQVIPSH--MN 1574
            ..:.|.....:|  :|.||...|.::..::......:.....:::||..|...:|:.:...  ..
Human  2508 LVSTDEGNENSK--ANLEEVAEVVRITKQLTLGRTVEPQDIAVLTPYNAQASEISKALRREGIAG 2570

  Fly  1575 ITPQTVDSYQGLEKDVIIISNART----------------RGCGFLTNYQRLNVALTRPRRCLVI 1623
            :...::...||.|...:::|..||                :..||:.:..::|||:||.:..|.:
Human  2571 VAVSSITKSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCL 2635

  Fly  1624 CGNFEDLKSVEMWRNLLD 1641
            .|:...|:...:||:|||
Human  2636 IGDHLLLRCCPLWRSLLD 2653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7504NP_001137907.1 FHA 4..96 CDD:238017
FHA <10..101 CDD:224630
AAA_11 1171..1428 CDD:289831 79/309 (26%)
AAA_19 1194..1251 CDD:289986 24/68 (35%)
YtxH <1293..1347 CDD:295162 5/56 (9%)
AAA_12 1435..1626 CDD:289832 47/222 (21%)
HELZ2XP_024307774.1 ZnF_U1 39..69 CDD:197732
AAA_11 541..705 CDD:331082
UvrD_C_2 715..915 CDD:328976
RNB 1334..1693 CDD:214935
AAA_11 2180..2427 CDD:315699 79/309 (26%)
AAA_12 2434..2639 CDD:315700 48/223 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147825
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

Return to query results.
Submit another query.