DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and HCS1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_012908.1	Gene:	HCS1 / 853852	SGDID:	S000001500	Length:	683	Species:	Saccharomyces cerevisiae

Alignment Length:	802	Identity:	209/802 - (26%)
Similarity:	328/802 - (40%)	Gaps:	212/802 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   940 KECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILKWANQWLKHGSVDAVAEQDVLMPIPPEFD 1004
            ||.....|||.:..||         .||:..||.:...:.|.|..   :.:|..::
Yeast     3 KELASKFLSSIKHERE---------QDIQTTSRLLTTLSIQQLVQ---NGLAINNI--------- 46

  Fly  1005 SFKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYT 1069
            ..:|.|...:..:.:||...:..:.||...:.....::.|....      |:||:|...|....:
Yeast    47 HLENIRSGLIGKLYMELGPNLAVNDKIQRGDIKVGDIVLVRPAK------TKVNTKTKPKVKKVS 105

  Fly  1070 -------LYCCGMLKETFANLLELKF-VSGNVFDLTFEILKQDISEEKLKNIKQLTARPVVDSLR 1126
                   ..|.|::.:.....:.:.. .|.:|...||      .|..||..:|...   ||...|
Yeast   106 EDSNGEQAECSGVVYKMSDTQITIALEESQDVIATTF------YSYSKLYILKTTN---VVTYNR 161

  Fly  1127 VELGALSAVHQLR--SSPLCRRILKPTQTVNEVSLPKQPF-----TFKGCH-----KLNEHQENI 1179
            :|    |.:.:|.  |||:..:|::  ..|||     :||     :|:...     .||:.|:..
Yeast   162 ME----STMRKLSEISSPIQDKIIQ--YLVNE-----RPFIPNTNSFQNIKSFLNPNLNDSQKTA 215

  Fly  1180 VLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIV 1244
            :...       :...||:|.|||||||:..:.||..|.|..|.    :.:||||..||.:||.|:
Yeast   216 INFA-------INNDLTIIHGPPGTGKTFTLIELIQQLLIKNP----EERILICGPSNISVDTIL 269

  Fly  1245 GLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDL 1309
            ..|..:  |.|.   .|||.|...::            .:..|...|..:||:|. |:|    |:
Yeast   270 ERLTPL--VPNN---LLLRIGHPARL------------LDSNKRHSLDILSKKNT-IVK----DI 312

  Fly  1310 KDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTL-- 1372
            ..||.:|.::......|  :|.::...:::|:...|     ::.||:.....:.::.|:.|||
Yeast   313 SQEIDKLIQENKKLKNY--KQRKENWNEIKLLRKDL-----KKREFKTIKDLIIQSRIVVTTLHG 370

  Fly  1373 SSCVKLAN-YVD-----FFDICIVDEATQCTEPWTLLPMRFGLTH------MVLVGDMQQLPAVV 1425
            ||..:|.: |.|     .||..|:||.:|..||...:|:   :.|      :||.||.:|||..:
Yeast   371 SSSRELCSLYRDDPNFQLFDTLIIDEVSQAMEPQCWIPL---IAHQNQFHKLVLAGDNKQLPPTI 432

  Fly  1426 LSK--KAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFK-------LSTQYRMHPEICRWP 1481
            .::  |.:...|..::||||                  .|:|.       |:.||||:.:|..:|
Yeast   433 KTEDDKNVIHNLETTLFDRI------------------IKIFPKRDMVKFLNVQYRMNQKIMEFP 479

  Fly  1482 NQYFYEDQLINAECTAR--------------------FASPLIPYCVINLKYTCDSNGAQNKSIS 1526
            :...|..:|: |:.|..                    ...|||.|         |:.|.:.:..:
Yeast   480 SHSMYNGKLL-ADATVANRLLIDLPTVDATPSEDDDDTKIPLIWY---------DTQGDEFQETA 534

  Fly  1527 NNEEARFVAKLLTE-----MDKHMPSKRF------SYGLISPYQNQCYALSQVIPSHMNITP--- 1577
              :||..:.....|     :.:|:.:.|.      |.|:||||..|...|.::|...:.:|.
Yeast   535 --DEATILGSKYNEGEIAIVKEHIENLRSFNVPENSIGVISPYNAQVSHLKKLIHDELKLTDIEI 597

  Fly  1578 QTVDSYQGLEKDVIIISNARTR---GCGFLTNYQRLNVALTRPRRCLVICGNFE--------DLK 1631
            .|||.:||.||||||:|..|:.   ..|||...:|||||:|||||.||:.||.|        .||
Yeast   598 STVDGFQGREKDVIILSLVRSNEKFEVGFLKEERRLNVAMTRPRRQLVVVGNIEVLQRCGNKYLK 662

  Fly  1632 SVEMWRNLLDDARKRKVYFNLD 1653
            |...|.....|.|    |.|:|
Yeast   663 SWSEWCEENADVR----YPNID 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	77/270 (29%)
		AAA_19	1194..1251	CDD:289986	25/56 (45%)
		YtxH	<1293..1347	CDD:295162	13/53 (25%)
		AAA_12	1435..1626	CDD:289832	67/234 (29%)
HCS1	NP_012908.1	TIGR00376	15..679	CDD:273041	202/787 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810