DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Helz

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_938040.1	Gene:	Helz / 78455	MGIID:	1925705	Length:	1965	Species:	Mus musculus

Alignment Length:	729	Identity:	168/729 - (23%)
Similarity:	272/729 - (37%)	Gaps:	210/729 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1008 NYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRV--------NSKPFGK 1064
            ||:.....|:.:|.::..:...:.|         :.|:.|.:...::|.|        |.:.||:
Mouse   455 NYQARLHDLLYIEEIAQYKEVSRFN---------LKVQLQILASFMLTGVSGGAKYAQNGQLFGR 510

  Fly  1065 FVLY------TLYCCGMLKETFANLLEL------KFVSG-----NVFDLTFEILKQD-----ISE 1107
            |.|.      ||  .|.|..|..|.:.|      |.|..     .|::.|.|...:|     ||.
Mouse   511 FKLTETLSEDTL--AGRLVMTRVNAVYLLPVPKEKLVQSQGTKEKVYEATIEEKTKDYVFLRISR 573

  Fly  1108 EKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCR------RILKPTQTVNEVSL------- 1159
            |   ..::|:.||..| ::|||     ..||...|||.      ||........::|:
Mouse   574 E---CCEELSLRPDCD-IQVEL-----QFQLNRLPLCEMHYALDRIKDNAVLFPDISMTPTIPWS 629

  Fly  1160 PKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAK 1224
            |.:.:..:...:||..|:..||.....:...|.|  .||.||.||||:..:::         |||
Mouse   630 PNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPP--VLIIGPYGTGKTFTLAQ---------AAK 683

  Fly  1225 TL-----DRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFN 1284
            .:     ..:||||.|||:|.|..:           :|..|    ...|..:..:||  |..:|.
Mouse   684 HILQQQETSRILICTHSNSAADLYI-----------KDYLH----PYVEAGNPQARP--LRVYFR 731

  Fly  1285 KAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPL 1349
            ....:.:..|..:...|...|                  ||:   |:.|||.
Mouse   732 NRWVKTVHPVVHQYCLISSTQ------------------STF---QMPQKED------------- 762

  Fly  1350 TQREEFEISHMCVTRANIICTTLSSCVKLANYVD----FFDICIVDEATQCTEPWTLLPMRFGL- 1409
                        :.:..::..|||:...|.. :|    ||...::|||.|..|..|::|:....
Mouse   763 ------------ILKHRVVVVTLSTSQYLCQ-LDLEPGFFTHVLLDEAAQAMECETIMPLALATK 814

  Fly  1410 -THMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRM 1473
             |.:||.||..||...|.|:.|.:..|..|:.||:....      |..:...    ..|...||.
Mouse   815 NTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHY------PAEFPCR----ILLCENYRS 869

  Fly  1474 HPEICRWPNQYFYEDQLI--NAECTARFASPLIPYCVINLKYTCDSNGAQNKSIS---NNEEARF 1533
            |..|..:.::.|||.:|:  ..:...:...||       ..:|......|.|:.:   ||.|...
Mouse   870 HEAIINYTSELFYEGKLMASGKQPAHKDFYPL-------TFFTARGEDVQEKNSTAFYNNAEVFE 927

  Fly  1534 VAKLLTEMDKHMP-----SKRFSYGLISPYQNQCYALSQVIP----SHMNITPQTVDSYQGLEKD 1589
            |.:.:.|:.:..|     ....|.|:::||.:|.:.:...:.    |.:|:  :.|.:.||.:..
Mouse   928 VVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNV--ERVLNVQGKQFR 990

  Fly  1590 VIIISNARTR-GC-----------------------GFLTNYQRLNVALTRPRRCLVICGNFEDL 1630
            |:.:|..||| .|                       |||:||:.||.|:||.:..:.:.|:...|
Mouse   991 VLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVAL 1055

  Fly  1631 KSV----EMWRNLL 1640
            .|:    :.|...:
Mouse  1056 CSIGRCRKFWERFI 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	65/267 (24%)
		AAA_19	1194..1251	CDD:289986	20/61 (33%)
		YtxH	<1293..1347	CDD:295162	9/53 (17%)
		AAA_12	1435..1626	CDD:289832	51/228 (22%)
Helz	NP_938040.1	zf-CCCH	181..204	CDD:366217
		DEXXQc_HELZ	641..868	CDD:350835	73/311 (23%)
		DEAA box	795..798		2/2 (100%)
		SF1_C_Upf1	869..1069	CDD:350195	47/208 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1249..1351
		Atrophin-1	1262..>1416	CDD:367360
		Amelogenin	<1338..>1414	CDD:197891
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1361..1380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1389..1450
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1464..1492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1632..1656
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810