DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Zgrf1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_017175214.1	Gene:	Zgrf1 / 71643	MGIID:	1918893	Length:	2044	Species:	Mus musculus

Alignment Length:	2180	Identity:	445/2180 - (20%)
Similarity:	742/2180 - (34%)	Gaps:	729/2180 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SSVW---YLEHVTTGARLILHN--GTNLMGRHSRCRIILGGQYQFVSREHANIIVSEKGVEVESL 61
            |.||   .|:....|.:.||::  |..|.....:|..:..|. ...|..:...:...|.|...::
Mouse    18 SKVWQDGVLKITHLGNKAILYDDKGACLESLFLKCLEVKPGD-DLESERYLITVEEAKAVGSRAV 81

  Fly    62 NPLNGLFINGGKLGDKINRLAVAEG------STISLGVTGVNL-NEITGIHAIFILKKKEPVVEE 119
            .|      :|       :|.|:..|      |:.|||.....| .:.||....:.:.||..:.|.
Mouse    82 EP------DG-------SREALESGSRTLVSSSRSLGCQPSGLKRKATGFQRPYKMPKKVTITEN 133

  Fly   120 IVLSSDDDDTTPLPAVRCPTGTQPTEFNLKQQIPNFGGKQDPGQEEEVLPSSSNLHLPKLTEVKQ 184
            ...::...|..|.|                           ||  ..:||:.|:. ||....|.|
Mouse   134 SEPAASLGDENPGP---------------------------PG--PRLLPTFSST-LPLFPTVGQ 168

  Fly   185 EIVKHTSEEIQN--IFG--EPSDAILNSVLELNPYLYNKLTNKTANNEITRKKIHDGDCIELDTD 245
            :.:...|.:.|:  .|.  |.||..|:.     |..|.|:...|...|       |..|..:.::
Mouse   169 KDLTPVSTDNQSPITFSNRERSDTPLSL-----PSSYFKINTNTLGKE-------DKLCFPVSSE 221

  Fly   246 TDRRSISEAQKAEDPSAEREVDDE----EEYDESFAMSQAVIREM---KAEMH------------ 291
            |..   |::..|.:|.....:|..    .:...|.|...|:::..   :.::|
Mouse   222 TKH---SDSLLASEPMRRNGLDSHCPGVSQNVRSKAQILALLKSSSTNRKDLHGEIPGHFPKIEP 283

  Fly   292 ------VSDGEEDFLLTNGMGNL--------PEGSPSNQAYDDIVYV--------SDSDDDELYD 334
                  :|..|||:..|..:|||        |..:.|..|.    |:        |.:|:::..|
Mouse   284 QGCLNIISKPEEDYAETQSIGNLRCEQQSENPTRTTSRWAR----YLPSQRSPPCSAADENDTED 344

  Fly   335 K--------VADWSKLLSQKVVPDVIEMSQTYPLENEHKDSDSDLD------------------- 372
            |        :.:.|:||.:|     .|:.:|...:.|....|..:|
Mouse   345 KPEAQEDVNIFNLSELLQKK-----SELFETCSKKGELHSEDKPVDNTCQYWNQEDNLAPSFCKN 404

  Fly   373 ---IGAKKPKRTLRISSSSDEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPDLPAVRKL 434
               :.:...|....:.|.||...:.:|.|:|.::...|..|:.        ||:.....|..|
Mouse   405 SSVLVSCSSKENASLLSESDIQYSSKVPVNQHEKVWTREGSQG--------ADADAALEPEYR-- 459

  Fly   435 SVSSIDSVYENKQTKLNSKLKSCLKSPTKTSVDNMENMTETKSCSNRQREQI--VASRNEP---T 494
            .||.:..: .:|||::.:.|        .||....:::.:..|.||..||.:  |....:|   .
Mouse   460 PVSPLPEI-GHKQTEVEASL--------STSSRISDDIADMGSKSNADREDLKTVHKAVQPFLEV 515

  Fly   495 NICPQKIETNKTSTRKRFVSTTSRDE---------------------------------LSTTSK 526
            :......||:.|....:..|..|:|.                                 ||:|..
Mouse   516 SFNLSNFETSDTDEASQEDSRLSQDSERWEKEAVLTDDSCVQKSCEDIGCREIVGKLPLLSSTDD 580

  Fly   527 EIKDA----------------------PKNNVEPPKKMLRSRSKSCYIDRPVELDEHITKNE--- 566
            |.|:|                      |..:|:..|.:    ...|:.|....||..:..:|
Mouse   581 EPKEALPADGTLLSEFCDRTCVGFNSGPHGDVKTGKAL----EGQCHSDTGSSLDSSLEWSEDVA 641

  Fly   567 --------------------VPLKKKYESVDNSKEELIVTLEAPAMLTTPT----------KSKT 601
                                |...||...|:.|       |.:|.:||..|          ...|
Mouse   642 GDSREDASQSIQGNAINCGGVSPSKKPRGVNRS-------LYSPYLLTAVTDPAPENSDLLSEGT 699

  Fly   602 QCVKKKATQTRGRRKT---IHSRDEIRSLTAEAEENKKISPAKQTNEEI------PIPTKSPLKR 657
            |....::.:.|...:.   |.|.|....|.:..:::.:....::::.:|      |:..|.|:.|
Mouse   700 QLFILQSHRDRNDEQVLSPISSSDISGQLLSTTQDHFECHELEESSTQISSPLFYPMGIKHPIYR 764

  Fly   658 N-------ARLLNRSKSCYMDRLVI------------SETEDPAKKVIKDISPTKSDTTDNV--- 700
            :       ::.|.|.:|...|...:            |::.....:||.::|..||.:..:.
Mouse   765 DSEAYISESKELGRIRSLPCDHFEVETTQRNQQSWATSKSSSELSEVINNMSLLKSQSEHSTALG 829

  Fly   701 -LNFV--------DVRQTRGPSVI----EAPSLPKNRGKLR---------------------GVS 731
             |..:        :|..:|.|.|.    ::|::..:|..|.                     ..:
Mouse   830 HLTILKKKHAFPHEVPHSRDPDVSPKARKSPAIEVSRALLECPCEHRASQQPVEFQGHQVKGSAT 894

  Fly   732 AEVKVKDKVLDR--QRF---IDYQAEM--NAKWKQ---------------KPKDK---------- 764
            :.|.|:...|.|  .:|   |||:..:  ...|..               .|:.|
Mouse   895 SGVMVRGHSLQRGCTQFPDSIDYENFLTDTCVWTPGLPSTYGQTDFLQVISPEQKIPALSPAPTF 959

  Fly   765 ----KKED-------EKLKECRREALKKLSEKPKENSHRSTTNKRKNPTSVPTVQNTNRGGFLTK 818
                :.||       |.||......||.:..:..:|..|           .|.:...:.......
Mouse   960 SFNTRNEDTVLELSEESLKTRTLPGLKTIGFQDSKNLQR-----------FPFLSGASAPFATLP 1013

  Fly   819 GVDGPAP----KLAKTDNAKPP---------------------------------PKKPVP---- 842
            ..||||.    .....|:|:.|                                 ||....
Mouse  1014 ADDGPAVLDPCSFMIDDDAREPSGSSMLNLCEESGLSFDLGLEGQGGTPGGVSLLPKSSTQSKWL 1078

  Fly   843 --KQPPAIETFSQQLQAAD---------------------------------KAVLHPQPQCSRP 872
              :.||...:.:....|::                                 |.:||.|.|  ..
Mouse  1079 KYQNPPQCNSTAPNRLASEVTEGLFAEAVSGLHFSHTSESESSVDPVRLQMIKGLLHQQQQ--DL 1141

  Fly   873 VERKEA-ELARNQRTC----NKVTFAEMELYHQKAEDSKKL----------QKKL------RKVH 916
            |.||:| .|..|| ||    ::.........:.:|:|.:::          ||.:      |:||
Mouse  1142 VSRKQAFSLTLNQ-TCKTQEHETVLGSSASKNCRAKDLQEINNSDLCFPNGQKIISAYLPQRQVH 1205

  Fly   917 --------------FNDDVKVH-------CIERVKGASSKVQGRKECIKLRLSSYRERR-EWIR- 958
                          |...:..|       ..:|:..|.|||.         :|.|...: |.:|
Mouse  1206 IPAVFQSPAHYRQVFTASIIEHLNILLFELAQRLYKALSKVD---------ISFYTSSKGETMRS 1261

  Fly   959 -RENKPVNDIRQHSRSIL--------------------------KWANQWLKHGSVDAVAEQDVL 996
             :.|.|.....|.::.::                          ||..: :..|.:.....|..:
Mouse  1262 GKNNSPSCHHNQPAKLVMVKKEGPNKGRLFYTCDKSKDNQCKFFKWLEE-VTPGQLPQNTSQSTM 1325

  Fly   997 MPIPPEFDSFKN------------YREIFVPLM-----------KLELLSTIERDYKINNKNTFS 1038
            :     |:..|:            |.|..:.|.           ||:.|:|:..|:....|:...
Mouse  1326 V-----FNDIKSIGSYLRSQKVPVYEECQLLLRRGFDFQRKQCGKLKKLTTVNPDFYSETKSKIY 1385

  Fly  1039 VSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCC----GMLKETFANLLELK--FVSGNVFDLT 1097
            :.|...|:..:..:....|.||.. .|.|.|...|    |........||.||  |.|....::|
Mouse  1386 LKLSRRESSSVYSKGDLWVISKTL-DFELDTFIACSAFFGPSSVNEVELLPLKGYFPSNWPTNIT 1449

  Fly  1098 FE-ILKQDISEE--KLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKP-----TQTV 1154
            .. :|..:.|.|  .|:||:.. ..|....|...|.|:|....:.|..:.:|...|     .:|.
Mouse  1450 VHALLVCNASTELTTLQNIQDY-FNPAALPLMPYLLAMSQSATVSSKNISKRKFIPPAITSIKTK 1513

  Fly  1155 NEVSLPKQPFTFK------GCHKLNEHQENIVLHTYQRII------DDLQP-----SLTLIQGPP 1202
            .|:.|..   |.:      ..|:||:.|...::...|.:.      |.|:|     .:|:|.|..
Mouse  1514 TELHLGA---TLQLARELINVHRLNKDQATALIQIAQMMASQGSDEDALEPFGHSLPITVIHGVF 1575

  Fly  1203 GTGKSRVIS----------ELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRD 1257
            |.|||.:::          |.|.....|||...   |:|:.:.:|.|||.:  |||  |..:..:
Mouse  1576 GAGKSYLLAVVILFLVELFEKCDSGTVGNARPW---KVLVSSSTNVAVDRV--LLG--LLSLGFE 1633

  Fly  1258 QFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNL 1322
            :|  :|.|...|::....|:||.|..:...||            ||:.:..||:|:      |.:
Mouse  1634 KF--IRVGSVRKIAKPVLPYSLHAGSDNESEQ------------LKELNALLKEEL------TPI 1678

  Fly  1323 TSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCV-KLANYVDFFD 1386
            ...|:.:.::|                   .:...:.:.:.:..::..|.::|. ...|.:. |.
Mouse  1679 ERVYVRKSIEQ-------------------HKLGTNRVLLKQVRVVGVTCAACAFPCLNDLK-FP 1723

  Fly  1387 ICIVDEATQCTEPWTLLPM-RFGLTHMVLVGDMQQLPAVVL-SKKAIDFGLSNSMFDRI------ 1443
            :.::||.:|.|||.:|||: ||....::||||.:|||..:. |..|.:.||..::|||:
Mouse  1724 VVVLDECSQMTEPASLLPIARFQCEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRLCLMACT 1788

  Fly  1444 QRSLQT---------QLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLINAECTARF 1499
            .:.||.         ..|:.|.      |...|.||||.||.|....|..|||..|:|. .:.|.
Mouse  1789 SKMLQVTAGCRLCGWMKDEEGH------KPVLLRTQYRCHPAISAIANDLFYEGSLVNG-ISERE 1846

  Fly  1500 ASPLIPY----CVINLKYTCDSNGAQ----NKSISNNEEARFVAKLLTEMDKHMPS--KRFSYGL 1554
            .||::.:    |..|:      .||:    ..|..|..||.|..||:..:   |.|  :....|:
Mouse  1847 RSPVLEWLPTLCFYNV------TGAEQVERENSFVNVAEATFTLKLIQSL---MASGVESCMIGV 1902

  Fly  1555 ISPYQNQ----CYALSQVIPSHMNITP---QTVDSYQGLEKDVIIISNARTRGCGFLTNYQRLNV 1612
            |:.|::|    |..||.|...|.::..   .|||::||.||::.|:|..|||..||:.:.:|:||
Mouse  1903 ITLYKSQMYKICNLLSAVDVGHPDVKAVQVSTVDAFQGAEKEITILSCVRTRQVGFIDSEKRMNV 1967

  Fly  1613 ALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRK 1647
            ||||.||.|:|.|:...|:...:|..::.....|:
Mouse  1968 ALTRGRRHLLIVGSLSCLRKNRLWGRVIQHCEGRE 2002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017	22/102 (22%)
		FHA	<10..101	CDD:224630	20/99 (20%)
		AAA_11	1171..1428	CDD:289831	69/280 (25%)
		AAA_19	1194..1251	CDD:289986	21/66 (32%)
		YtxH	<1293..1347	CDD:295162	8/53 (15%)
		AAA_12	1435..1626	CDD:289832	73/222 (33%)
Zgrf1	XP_017175214.1	DUF2439	3..75	CDD:371019	12/57 (21%)
		zf-GRF	1267..1311	CDD:284302	4/44 (9%)
		TIGR00376	<1568..2003	CDD:273041	142/498 (29%)
		AAA_12	1774..1981	CDD:372468	73/222 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920