DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7504 and Upf1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_003751614.1	Gene:	Upf1 / 684558	RGDID:	1589127	Length:	1124	Species:	Rattus norvegicus

Alignment Length:	766	Identity:	206/766 - (26%)
Similarity:	324/766 - (42%)	Gaps:	204/766 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   993 QDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQD-MCYRLVTR 1056
            |.||:    .::....|:.||.||:||      |.||....|.:        :||| :..|....
  Rat   285 QHVLL----RYEDAYQYQNIFGPLVKL------EADYDKKLKES--------QTQDNITVRWDLG 331

  Fly  1057 VNSKPFGKFVLYTLYCCGMLKETFAN-------LLELKFVSGNVFDLTFEILKQDISEEKLKNIK 1114
            :|.|....|.|        .|....|       |.:::.:.|:...|.:   |.|:: ...|.|.
  Rat   332 LNKKRIAFFTL--------PKTDSGNEDLVIIWLRDMRLMQGDEICLRY---KGDLA-PLWKGIG 384

  Fly  1115 QLTARP------VVDSLRVELGA-LSAVHQLR--------SSPLCRRILKPTQTVNEVS------ 1158
            .:...|      :...||..:|| :...|..:        |....:..|| |..|:|.|
  Rat   385 HVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQVDFVWKSTSFDRMQSALK-TFAVDETSVSGYIY 448

  Fly  1159 ----------------LPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKS 1207
                            |||: ||.:|...||..|...|....||       .|:||||||||||:
  Rat   449 HKLLGHEVEDVVIKCQLPKR-FTAQGLPDLNHSQVYAVKTVLQR-------PLSLIQGPPGTGKT 505

  Fly  1208 RVISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSH 1272
                 :...|:..:.|:..:..:|:||.||.|||.:.            ::.|  :.|:
  Rat   506 -----VTSATIVYHLARQGNGPVLVCAPSNIAVDQLT------------EKIH--QTGL------ 545

  Fly  1273 YSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQ------HNDLK--DEIQQLKEKTNLTSTYLLQ 1329
                             |:.|:..::.|.:...      ||.::  |.:.:|::         ||
  Rat   546 -----------------KVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQK---------LQ 584

  Fly  1330 QLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCV-----KLANYVDFFDICI 1389
            ||:.:..:|.....:....|.:..|.|:    :..|::||.|   ||     :||. :.|..| :
  Rat   585 QLKDETGELSSADEKRYRALKRTAEREL----LMNADVICCT---CVGAGDPRLAK-MQFRSI-L 640

  Fly  1390 VDEATQCTEPWTLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKP 1454
            :||:||.|||..::|:..|...::||||..||..||:.|||...|||.|:|:|:.
  Rat   641 IDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLV---------- 695

  Fly  1455 GSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLINAECTA---------RFASPLIP--YCV 1508
                ::..:..:|..||||||.:..:|:..|||..|.|....|         ::..|..|  :.|
  Rat   696 ----VLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYV 756

  Fly  1509 INLKYTCDSNGAQNKSISNNEEARFVAKLLTEMDKHMPSKRFSYGLISPYQNQCYALSQVI---- 1569
            ...:....|:|.   |..|..||..|.|:.|::.| ..:|....|:|:||:.|...|.|.:
  Rat   757 TQGQEEIASSGT---SYLNRTEAANVEKITTKLLK-AGAKPDQIGIITPYEGQRSYLVQYMQFSG 817

  Fly  1570 ----PSHMNITPQTVDSYQGLEKDVIIISNART---RGCGFLTNYQRLNVALTRPRRCLVICGNF 1627
                ..:..:...:||::||.|||.||:|..|.   :|.|||.:.:||||||||.|..::|.||.
  Rat   818 SLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNP 882

  Fly  1628 EDLKSVEMWRNLLDDARKRKVYFNLDRDDVNDLDRSLIK----KMMVNTIN 1674
            :.|....:|.:||...:::|.   |....:|:|..||::    :.:|||:|
  Rat   883 KALSKQPLWNHLLSYYKEQKA---LVEGPLNNLRESLMQFSKPRKLVNTVN 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	71/269 (26%)
		AAA_19	1194..1251	CDD:289986	21/56 (38%)
		YtxH	<1293..1347	CDD:295162	11/61 (18%)
		AAA_12	1435..1626	CDD:289832	65/212 (31%)
Upf1	XP_003751614.1	DNA2	140..915	CDD:224037	200/749 (27%)
Upf1	XP_003751614.1	DEXXQc_UPF1	476..709	CDD:350797	82/313 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820