DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and ZNFX1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_066363.1	Gene:	ZNFX1 / 57169	HGNCID:	29271	Length:	1918	Species:	Homo sapiens

Alignment Length:	1303	Identity:	256/1303 - (19%)
Similarity:	429/1303 - (32%)	Gaps:	508/1303 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   797 KRKNPTSVPTVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPP-----------KKPVPKQPPAI-- 848
            :|.:..:.|...:||..|    .|||..|..|:.....||.           :.|.....||.
Human     4 RRPHLDARPRNSHTNHRG----PVDGELPPRARNQANNPPANALRGGASHPGRHPRANNHPAAYW 64

  Fly   849 ---ETF------------SQQLQAADKA--VLHPQPQCSRPVERKEAELARNQR-TCNKVTFAEM 895
               |.|            :|:..|:|:|  ..|.|...:|  .|...:..||:| ..:...|.:.
Human    65 QREERFRAMGRNPHQGRRNQEGHASDEARDQRHDQENDTR--WRNGNQDCRNRRPPWSNDNFQQW 127

  Fly   896 ELYHQK----AEDSKKLQKK----------------------LRKVHFNDDVKVHCIERV----- 929
            ...|||    .:.:|||..|                      |:::..:..:|.:.:|.:
Human   128 RTPHQKPTEQPQQAKKLGYKFLESLLQKDPSEVVITLATSLGLKELLSHSSMKSNFLELICQVLR 192

  Fly   930 KGASSKVQGR-----------KECIKLRLSSYRERREWIRRENKPVNDIR----QHSRSILKWAN 979
            |..|||:..:           .:.:|:.|.:|     .:....:|:.|||    :|..:|:....
Human   193 KACSSKMDRQSVLHVLGILKNSKFLKVCLPAY-----VVGMITEPIPDIRNQYPEHISNIISLLQ 252

  Fly   980 QWLKHGSVDAVAEQDVL------------------------------------------------ 996
            ..:......:|.|..:|
Human   253 DLVSVFPASSVQETSMLVSLLPTSLNALRASGVDIEEETEKNLEKVQTIIEHLQEKRREGTLRVD 317

  Fly   997 ------------------MPIPP--------------------EFDS--------FKNYREIFV- 1014
                              |||.|                    ::||        |:..||.||
Human   318 TYTLVQPEAEDHVESYRTMPIYPTYNEVHLDERPFLRPNIISGKYDSTAIYLDTHFRLLREDFVR 382

  Fly  1015 PLMK--LELLSTIERDYKINNKNTFSVSLINVETQ---DMC------YRLVTRVNSKPFGKFV-- 1066
            ||.:  ||||.:.| |..: .|..|....|..:|:   .||      |::  :.::||. |||
Human   383 PLREGILELLQSFE-DQGL-RKRKFDDIRIYFDTRIITPMCSSSGIVYKV--QFDTKPL-KFVRW 442

  Fly  1067 ------LYTLYCCGMLKETFANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTA--RPVVD 1123
                  ||....| |.|:.|...|.....:....||...|::...:|:.    :||.|  :|...
Human   443 QNSKRLLYGSLVC-MSKDNFETFLFATVSNREQEDLCRGIVQLCFNEQS----QQLLAEVQPSDS 502

  Fly  1124 SLRVELGALSAVHQLRSSPLCRRILKPTQTVNEVSLP------------KQP----------FT- 1165
            .|.||..|....:        |.:|:..|.|.|..:|            |:|          ||
Human   503 FLMVETTAYFEAY--------RHVLEGLQEVQEEDVPFQRNIVECNSHVKEPRYLLMGGRYDFTP 559

  Fly  1166 -FKGCHKLNEHQENIVLHTYQRI---------------IDD-----LQPSLT----LIQGPPGTG 1205
             .:......|...|:....:.||               :||     ||.:||    :||||||||
Human   560 LIENPSATGEFLRNVEGLRHPRINVLDPGQWPSKEALKLDDSQMEALQFALTRELAIIQGPPGTG 624

  Fly  1206 KSRVISELCLQTLYGNAAK---TLDR-KILICAHSNTAVDHIV-GLLG----SVLRVMNRDQFHL 1261
            |:.|..:: :|.|..|.:.   :|.: .||:..::|.|:|..: |:..    |::||..|....:
Human   625 KTYVGLKI-VQALLTNESVWQISLQKFPILVVCYTNHALDQFLEGIYNCQKTSIVRVGGRSNSEI 688

  Fly  1262 LR-FGMHEKMSHYSRPFSLEAHFNKA------------------------------KEQKLQR-- 1293
            |: |.:.|..:......:|..|..:|                              :||.||:
Human   689 LKQFTLRELRNKREFRRNLPMHLRRAYMSIMTQMKESEQELHEGAKTLECTMRGVLREQYLQKYI 753

  Fly  1294 ----------------------------------------------------------------- 1293

Human   754 SPQHWESLMNGPVQDSEWICFQHWKHSMMLEWLGLGVGSFTQSVSPAGPENTAQAEGDEEEEGEE 818

  Fly  1294 -------------------------------------VSKENAEIL------------------- 1302
                                                 ..:|.|::|
Human   819 ESSLIEIAEEADLIQADRVIEEEEVVRPQRRKKEESGADQELAKMLLAMRLDHCGTGTAAGQEQA 883

  Fly  1303 -----------KKQHNDLKDEIQQLKEKT-------------NLTSTYLLQ----QLQQKEKKLQ 1339
                       ||....:|||:::|...|             :|:|.:.|.    ||.|.:.:.:
Human   884 TGEWQTQRNQKKKMKKRVKDELRKLNTMTAAEANEIEDVWQLDLSSRWQLYRLWLQLYQADTRRK 948

  Fly  1340 LISNQLS--------PPLTQREEFEISHMCVTRANIICTTLSSCVKLANYVDFFD--ICIVDEAT 1394
            ::|.:..        ..|..:|:..|    :..|.::..|.:...|....:...:  |.||:||.
Human   949 ILSYERQYRTSAERMAELRLQEDLHI----LKDAQVVGMTTTGAAKYRQILQKVEPRIVIVEEAA 1009

  Fly  1395 QCTEPWTLLPMRFGLTHMVLVGDMQQL-PAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYH 1458
            :..|..|:..:.....|::|:||.||| |:..:...|.:|.|..|:|:|:.:
Human  1010 EVLEAHTIATLSKACQHLILIGDHQQLRPSANVYDLAKNFNLEVSLFERLVK------------- 1061

  Fly  1459 LMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLINAECTARFASPLIPYCVINLKYT----CDSNG 1519
             ::....:|:.|:||.|||.|....:.|:| |.|.....::..  |.....||.:.    .:...
Human  1062 -VNIPFVRLNYQHRMCPEIARLLTPHIYQD-LENHPSVLKYEK--IKGVSSNLFFVEHNFPEQEI 1122

  Fly  1520 AQNKSISNNEEARFVAKLLTEM--DKHMPSKRFSYGLISPYQNQCYALSQVIP--SHMNITPQTV 1580
            .:.||..|..||.||.:|....  .:::||:   ..:::.|..|.:.|.:::|  :...:....|
Human  1123 QEGKSHQNQHEAHFVVELCKYFLCQEYLPSQ---ITILTTYTGQLFCLRKLMPAKTFAGVRVHVV 1184

  Fly  1581 DSYQGLEKDVIIISNARTR---GCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDD 1642
            |.|||.|.|:|::|..|:.   ..|||....|:.|||:|.::.:...||.:.|..|.:|..::..
Human  1185 DKYQGEENDIILLSLVRSNQEGKVGFLQISNRICVALSRAKKGMYCIGNMQMLAKVPLWSKIIHT 1249

  Fly  1643 ARK 1645
            .|:
Human  1250 LRE 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	82/482 (17%)
		AAA_19	1194..1251	CDD:289986	23/69 (33%)
		YtxH	<1293..1347	CDD:295162	17/212 (8%)
		AAA_12	1435..1626	CDD:289832	51/201 (25%)
ZNFX1	NP_066363.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..140		15/66 (23%)
		AAA_11	597..1038	CDD:289831	77/445 (17%)
		AAA_19	604..>667	CDD:289986	23/63 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..819		0/22 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..896		0/19 (0%)
		DNA2	<903..1254	CDD:224037	91/374 (24%)
		AAA_12	1051..1234	CDD:289832	52/202 (26%)
		NF-X1-zinc-finger	1372..1417	CDD:100116
		NF-X1-zinc-finger	1461..1505	CDD:100116
		LELP1	<1498..1562	CDD:291701
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810