DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG7504 and helz2b

DIOPT Version :9

Sequence 1:NP_001137907.1 Gene:CG7504 / 38904 FlyBaseID:FBgn0035842 Length:1676 Species:Drosophila melanogaster
Sequence 2:XP_699251.2 Gene:helz2b / 570654 ZFINID:ZDB-GENE-070912-617 Length:2781 Species:Danio rerio


Alignment Length:1971 Identity:398/1971 - (20%)
Similarity:691/1971 - (35%) Gaps:609/1971 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 FVSREHANIIVS------------------EKGVEVESLNPLNGLFINGGK-LGDKINRLAVAEG 86
            |.|.|..|::..                  :.|..:...||...:.|.|.| :|...      .|
Zfish  1028 FTSAEKENLLEMVRNQPALYKRGELVMEGYQSGYIIPYDNPSERIDIKGRKNIGMSF------PG 1086

  Fly    87 STISLGVTGVNLNEITGIHAIFILKKKEPVVEEIVLSSDD----------------------DDT 129
            ..:.:.:...:...:||  .:..|..:.|...|.|.|.:|                      |.|
Zfish  1087 DEVVVEIRRHDEGHLTG--RVLGLTNRSPTSSECVCSLEDENYNRKKLNPDQNLVPKMMIPLDHT 1149

  Fly   130 TP-------------LPAVRCP------TGTQPTEFNLKQQ----IPNFGGKQD---P-GQEEEV 167
            |.             :|..:|.      ||..|.....||.    :...|.|:.   | |:..::
Zfish  1150 TTKIRILVKKEARKLIPLWKCVSGNWTITGRVPINEQTKQNYVFVVQILGWKEHCSFPLGRVTDI 1214

  Fly   168 LPSSSNLHLPKLTEVKQEIVKHTSEEIQNIFGEPSDAILNSVLELNPYLYNK----------LTN 222
            ||..::|         :|.:|....|.:.:  .|.....|::||:.  :.:|          .|.
Zfish  1215 LPVGTSL---------EEGLKILKSEFKLM--SPPLMQENTLLEIR--IDDKRRKDFTGLKTFTV 1266

  Fly   223 KTANNEITRK--KIHD-GDCIELDTDTDRRSISEAQKAEDPSAEREVDDEEEYDESFAMSQAVIR 284
            ...|.|:...  .|:| |.|.|:       .:..|..|...|.:..:|             |..:
Zfish  1267 DPPNAEVLDDAISINDLGSCYEI-------GVHVADVASFVSKDSSID-------------AFAK 1311

  Fly   285 EMKAEMHVSDGEEDFLLTNGMGN-----LPEGSPSNQAYDDIVYVSDSDDDELYDKVADWSKLLS 344
            :|.|..:....|..|:....:..     ||  ....:|...||.| :.....:..|..|.|.:.|
Zfish  1312 DMGATFYAPGKEPAFMFPKHLSTTCWSLLP--GKDRKAISLIVEV-EKQSGVITKKTFDLSMVKS 1373

  Fly   345 QKVVPDVIEMSQTYPLENEHKDSDSDLDIGAKKPKRTLRISSSSDEDSADEVIVH------QTKQ 403
            ::.:        ||   ||.:|.....|       ..||..:..|   ...|..|      :|:.
Zfish  1374 KRQL--------TY---NEAEDIICQCD-------GELRFDTLED---CVRVAYHFARSQRKTRL 1417

  Fly   404 K-----GRRSKSKSPNDHVVRQADSTTPDLPAVRKLSVSSIDSVYENKQTKLNSKLKSCLKSPTK 463
            |     .:.:|.:.|.:   |:|.....:|..:....||...|.|.:  ||..:.|: |..||..
Zfish  1418 KEDWSYAQLNKHQKPGE---REAHRMIEELNIMFNHEVSKFLSEYTD--TKSCTPLR-CQDSPNA 1476

  Fly   464 TSVDNMENMTETKSCSNRQREQIVASRNEPTNICPQKIETNKT------STRKRFV--------- 513
            .:::.:         ||:..|.|..|.:...::..|:::.|..      |...|:|         
Zfish  1477 EALEKI---------SNQHMELIPFSSHLTFHLERQRMDLNNAVTFTVYSLGSRYVHPNNNPNPE 1532

  Fly   514 ------STTSRDELSTTSKEI----------------KDAPKN--------NVEPPK-------- 540
                  |:..||.:|.:..|.                :|..:|        |:.|.|        
Zfish  1533 ANSSPLSSQLRDAISVSESEFHFEIGIHKADFLNYVSEDNIQNLGAQSDMWNLAPGKKRCAISLM 1597

  Fly   541 -------------KMLRSRSKSCYIDRPVELDEHITKNEVPLKKKYESVDNSKEELIVTLEAPAM 592
                         ||:.||.:||......|.|..|  |::          ..||....|||...:
Zfish  1598 LKVEKRNGKLVEEKMVLSRIRSCKALSYSEADSII--NQL----------GEKEMKFGTLEDCIL 1650

  Fly   593 LTTPTKSKTQCVKKKATQTRGRRKTIHSRDEIRSLTAEAEENK------------KISPAKQTNE 645
            :          |.:.|...|.:|.:........|..|.:|::|            |.:..:..|:
Zfish  1651 V----------VCRFALDHRTKRLSRQVNSSNPSDLASSEDSKCRLMMEELKLMFKRASDQIINQ 1705

  Fly   646 EIPIPTKSPLKRNARLLNRSKSCYMDRL----VISETEDPAK--------------KVIKDISPT 692
            :...|..||     .|:||.|. |.::.    |:.:..||..              |.||..:.|
Zfish  1706 QTQFPNTSP-----GLVNRLKK-YNEKFESLQVLEKCLDPNNGQNCGSFIILTSVWKKIKSAALT 1764

  Fly   693 -----KSD--TTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLRGVS---AEVKVKDKVLDR---- 743
                 .:|  :||      |:.....|::::..:.......:|.:|   |.|......||.    
Zfish  1765 CDFYKMADLISTD------DIHPQLVPAIVQLSASINKAFFIRSLSCREALVGHYSLHLDSYTHA 1823

  Fly   744 ----QRFID--YQAEMNAKWKQKPKDKKKEDEKL--KECRREALKKLSEKPKENSHRSTTNKRKN 800
                :|:||  .|..|:|....:|.:..:.|..|  ::|:|...:....:.|..:.:...|.:| 
Zfish  1824 SSPIRRYIDVVLQRLMHAVLGNRPVEYSQTDIDLLCEKCKRGEKRAQEYESKVEALQIAVNLQK- 1887

  Fly   801 PTSVPTVQNTNRGGFLT-KGVDGPAPKLA-KTDNAKPPPKKPVPKQPPAIETFSQQLQAADKAVL 863
                   |:|.:..|:| ...|..:.||: ..|....|.|.||.         .:.||..|:.:.
Zfish  1888 -------QSTYKVAFVTVVKRDSESFKLSFPFDKGTFPEKLPVQ---------YRNLQLEDQPLF 1936

  Fly   864 HPQPQ---------------CSRPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKKLR 913
            ..:|:               ...|::..:......|.|...:..|..:   :|.:::|.|   :.
Zfish  1937 IKKPKHVKLTWKKRIYGLSMTQSPLQNMKISSEIQQSTWQAIVEAVRD---EKWDEAKSL---VL 1995

  Fly   914 KVHFNDDVKVHCIERVKGASSKVQGRK-------------------------ECIKLRLSSYRER 953
            ..|..|:.:          :|::....                         :.::::|:|.|:|
Zfish  1996 AAHVKDNSR----------NSELSDTSRWDPDRTFTSEEDHYTDFQINLKVGDTVQVQLTSERDR 2050

  Fly   954 REW-----IRRENKPVNDIRQHSRSILKWANQWLKHGSVDAVAEQDVLMPIPPEFDSFKNYREIF 1013
            ..|     :.|.:.......:|:.:.:|..::...|             |....:.:.:.|.:|:
Zfish  2051 GYWAPTVQLFRLSSSFEICVEHTDNPIKCFSRIADH-------------PSKGSYSNVEEYVQIW 2102

  Fly  1014 VPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVL----------- 1067
            .||.::|..:|...|       :..|.:.||        .:|..:|:..|.|.|           
Zfish  2103 RPLCEMESAATAVDD-------SDCVVIENV--------AITWDDSRLSGNFSLPEENIKKWAIE 2152

  Fly  1068 YTLYCCGM------LKETFANLLEL--KFV-----------------SGNVFD-LTFEILKQDIS 1106
            :.|..|.:      |::..|...||  |:.                 |||.|. :.|.:....:.
Zfish  2153 FDLGRCLLCIRKRDLEQNQAEQSELDPKYFTWVAHAVTTLCSDSPENSGNKFKIINFNVKYASMK 2217

  Fly  1107 EEKLKNIKQLTARPVVDSLRVELGALSAVHQLR-SSPLCRRILKPTQTVNEVSLPKQPFTF---- 1166
            ..|.|..:..|.. ::..|..::...|||:.|: ::.|.:.|....:.||:.|....|...    
Zfish  2218 IPKFKRNETFTVE-IIPKLLPDIRKESAVNNLKGANELVQNIALKHRIVNQSSNQDVPLYLLMRE 2281

  Fly  1167 ---KGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRV-------ISELCLQTLYGN 1221
               .|..:|||.|       ::.:...|....|:|||||||||:.|       .|:|..:.|:..
Zfish  2282 EAPAGLPQLNESQ-------FKALEKALNGKFTIIQGPPGTGKTVVGAYIVYWFSQLNSRNLWRL 2339

  Fly  1222 AAKT-LDRK--ILICAHSNTAVDHIVGLL---G---SVLRVMNRDQFHLLRF---GMHEKMSHYS 1274
            ...| .|::  ||.|..||.:||.:...|   |   .:|||.:| |..:..:   |.:.::||.|
Zfish  2340 KDPTDKDKREVILYCGPSNKSVDVVAEYLLKFGEKLKLLRVYSR-QMEMQEYPYPGSNLQLSHKS 2403

  Fly  1275 RPFSLEAHFNKAKEQKLQRVSKENAEILKKQHN-------DLKDEIQQLKEKTNLTSTYLLQQLQ 1332
            |        .:..:.:|:.::..:.  ::..||       |..|.|:  .:..:||.|    .::
Zfish  2404 R--------QERSKPELRAITLHHR--IRMGHNPYSQRITDFDDRIK--SDPYSLTDT----DIE 2452

  Fly  1333 QKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICT-TLSSCVKLANYVDFFDICIVDEATQC 1396
            :.:|.|.      ...|.:.|..:|         |:|| |.::...|...:....| ::||....
Zfish  2453 EYKKLLN------DARLHELERHDI---------ILCTCTAAASPNLKKTLSARQI-LIDECAMA 2501

  Fly  1397 TEPWTLLPM-RFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDR-IQRSLQTQLDKPGSYHL 1459
            |||.||:|: .|....:||:||.:||..:|.:......|::.|:|:| :.|::.           
Zfish  2502 TEPQTLVPLVSFKPEKVVLLGDHKQLRPIVKNNHVRRLGMTRSLFERYMDRAIM----------- 2555

  Fly  1460 MHTKLFKLSTQYRMHPEICRWPNQYFYEDQL----------INAECTARFASPLIPYCVINLK-- 1512
                   |.||||||.|||::|::.:|.|.|          :|||...|..|..|.:..|..:  
Zfish  2556 -------LDTQYRMHEEICKFPSEAYYNDMLKTVVRERTSVLNAETEGRRQSKRILFGDIRGEEI 2613

  Fly  1513 --YTCDSNGAQNKSISNNEEARFVAKL---LTEMDKHMPSKRFSYGLISPYQNQCYALSQVIPSH 1572
              ....:.|.:| |.:|.:|.:...::   |..:.:..|.   ...::|||..|...:.:.:...
Zfish  2614 GLVVSTARGNEN-SKANFDEVKKAVEICIQLVTVGRVRPE---DIAILSPYNAQVAQIRERLSDF 2674

  Fly  1573 --MNITPQTVDSYQGLEKDVIIISNAR----------------TRGCGFLTNYQRLNVALTRPRR 1619
              ...|..|:...||.|...:|:|..|                ::..||:.:..::||.:||.:.
Zfish  2675 ELKGFTVTTITKSQGSEWQYVILSIVRSCPSDEIEPMPSREWLSKHIGFVGDENQINVGITRAQV 2739

  Fly  1620 CLVICGNFEDLKSVEMWRNLL 1640
            .|.|.||...|.....|:.||
Zfish  2740 GLCILGNQAVLNCSPAWQKLL 2760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7504NP_001137907.1 FHA 4..96 CDD:238017 12/73 (16%)
FHA <10..101 CDD:224630 12/78 (15%)
AAA_11 1171..1428 CDD:289831 76/284 (27%)
AAA_19 1194..1251 CDD:289986 25/72 (35%)
YtxH <1293..1347 CDD:295162 10/60 (17%)
AAA_12 1435..1626 CDD:289832 52/226 (23%)
helz2bXP_699251.2 AAA_11 530..725 CDD:289831
AAA 553..688 CDD:99707
DNA2 <647..959 CDD:224037
P-loop_NTPase <662..>721 CDD:304359
UvrD_C_2 735..935 CDD:304668
RNB 1255..1482 CDD:279157 55/276 (20%)
RNB 1544..1845 CDD:214935 65/334 (19%)
AAA_11 2289..2532 CDD:289831 75/282 (27%)
AAA_19 2297..>2368 CDD:289986 24/70 (34%)
AAA_12 2543..2746 CDD:289832 52/224 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.