DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and mov10a

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_002662576.2	Gene:	mov10a / 566858	ZFINID:	ZDB-GENE-091230-8	Length:	1001	Species:	Danio rerio

Alignment Length:	1170	Identity:	249/1170 - (21%)
Similarity:	402/1170 - (34%)	Gaps:	384/1170 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   606 KKATQTRGR-------RKTIHSRDEIRSLTAEAEENKKIS-----PAKQTNEEIPIPTKSPL--- 655
            |||..:.|:       :..::..|:.:|.   .::|...|     ||..::   |.||..|:
Zfish    59 KKARSSHGKIFFQWKPKMRVYYCDQWKSF---VQQNTSPSAPDSDPASSSS---PRPTFKPILTP 117

  Fly   656 --KRNARLLNRSKSCYMDRLVISETEDPAKKVIKD-----ISPTKSDTTDNVLNFVDVRQTRGPS 713
              |....:||:.:|             ...::|||     ||.....|..||...::
Zfish   118 KKKLATEILNKLRS-------------KRAELIKDKGGIEISSDPKATKGNVSFTIE-------- 161

  Fly   714 VIEAPSLPKNRGKLRGVSAEVKVKDKVLDRQRFIDYQAEMNAKWKQK---PKDKKKEDEKLKECR 775
                     ..|||      ..||..::::.....|.....|..|.:   ..||:         |
Zfish   162 ---------ELGKL------FVVKFHIVNQSEGCIYFTYYTALHKMRCFTLVDKR---------R 202

  Fly   776 REALKKLSEKPKENSHRSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGPA-------PKLAKTDNA 833
            ...:..|...|.|:            ..|....|.|..|..      ||       |::.....|
Zfish   203 VNRVSPLLLCPGED------------YDVEVHYNVNHPGHF------PATMYFEFCPEVDPPGTA 249

  Fly   834 KP-------------------PPKKPV-PKQPPAIETFSQQLQAADKAVLHPQPQCSRPVERKEA 878
            ||                   .|:.|. |||       :::|:...|.|     :...|.|....
Zfish   250 KPFCIVRELEAVVRTGLAETLGPESPYNPKQ-------NRRLRPKSKVV-----EEGVPPESSIT 302

  Fly   879 ELARNQRTCNKVTFAE--MELYHQKAEDSKKLQKKLRKVHFNDDVKVHCIERVKGASSKVQGRKE 941
            ...:|....|:..:..  .||...|.|||:         |....:|.| :.||:    ::...:.
Zfish   303 HDLKNMMKMNQYRYPAYLKELAKYKLEDSE---------HLPASLKQH-LPRVR----RLLDTQL 353

  Fly   942 CIKLRLSSYRER------REWIRRENKPVNDIRQHSRSILKWANQWLKHGSVDAVAEQDVLMPIP 1000
            |:|    :|.||      .|.|:.|    .||:::        :.:.|..::|...::.:::.:|
Zfish   354 CMK----NYSERFHLLLHLEEIQME----VDIKKY--------DLYGKTMTLDKTNKKLLILKVP 402

  Fly  1001 PEFDSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDM-CYR-LVTRVNSKPFG 1063
            .                ..|...::.|..|:|      |.|.:...|.: .|. .|.||.   ..
Zfish   403 G----------------VAENRPSVLRGDKLN------VCLSDDRNQPITVYEGYVHRVE---LD 442

  Fly  1064 KFVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTARPVVDSLRVE 1128
            |.:|           .|:..|..|||:...||:.|             ||.:...|  :....||
Zfish   443 KVIL-----------GFSRKLLQKFVNNMKFDVEF-------------NINRFPLR--LQHRAVE 481

  Fly  1129 LGALSAVHQLRSSPLCRRILKPT-QTVNEVSLPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQ 1192
            |....|:         ..:|.|: :......||......|.... |..|:..|.|.   :....:
Zfish   482 LAVQHAL---------GNVLFPSDKDTGHSELPHLSMFNKDLEN-NPEQKAAVQHI---LSGSSR 533

  Fly  1193 PSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRK-----ILICAHSNTAVDHIV-GLLGSVL 1251
            |:..||.|||||||:..:.|         |.|.:|:.     ||.||.||:|.|.:. .|||.|
Zfish   534 PAPYLIFGPPGTGKTVTVVE---------AIKQVDKSKAQSHILACAPSNSACDLLCERLLGHV- 588

  Fly  1252 RVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKK--QH---NDLKD 1311
                                        :||    :..:|...|::...:.:|  :|   |:.:|
Zfish   589 ----------------------------DAH----RIYRLCAPSRDPRTVPQKLLKHSNWNEAQD 621

  Fly  1312 EIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCV 1376
            ......::|.:..:.::..|                              ||...::    |..|
Zfish   622 SFLLPSKETLIGYSIIVVTL------------------------------VTAGRLV----SGGV 652

  Fly  1377 KLANYVDFFDICIVDEATQCTEPWTLL-------PMRFGLTHMVLVGDMQQLPAVVLSKKAIDFG 1434
            .:.::...|    :|||.|..||..::       |::   ..:||.||.|||..|:.|..|...|
Zfish   653 AMGHFTHIF----IDEAGQAVEPECIIGIAGLLDPLK---GQLVLAGDPQQLGPVLRSPLAQLHG 710

  Fly  1435 LSNSMFDRIQRS---LQTQLDKPGSYHLMH-TKLFKLSTQYRMHPEICRWPNQYFYEDQL----- 1490
            |..|:.:|:.:.   .|...|....|.... |||.:   .||.||.|.:.||:.|||::|
Zfish   711 LGQSLLERLMKRNALYQKSQDDNSKYDSRFVTKLLR---NYRSHPAILKIPNELFYENELQVFAN 772

  Fly  1491 -------INAECTARFASPLIPYCVINLKYTCDSNGAQNKSISNNEEARFVAKLLTEMDKHMPSK 1548
                   ...|...|...|::.:.|:..    |...|.:.|..|..|...:...|..:.:....|
Zfish   773 QMEREAFCQWEHLPRKGFPVVFHGVMGK----DEREANSPSFFNVTEIEVIVNYLNNLMQTQGKK 833

  Fly  1549 RF------SYGLISPYQNQC----YALSQV--IPSHMNITPQTVDSYQGLEKDVIIISNARTR-- 1599
            ..      ..|:|:||:.|.    .||:.|  :....:|...:|:.:||.|:.|||:|..|:.
Zfish   834 GLPKLGPNDIGIIAPYRKQVEKIRKALNTVGELKKWKDIKVGSVEEFQGQERKVIIVSTVRSSVN 898

  Fly  1600 --------GCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFNLDRDD 1656
                    ..|||:|.:|.|||:||.:..|::.||...|.....|:..:....:.:.|...|..|
Zfish   899 YVKMDQDFNIGFLSNEKRFNVAMTRAKGLLIVVGNPVILSKDPTWQKFIQYCEQEQGYTGFDYKD 963

Fly 1657 1656
Zfish 964 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	60/274 (22%)
		AAA_19	1194..1251	CDD:289986	24/62 (39%)
		YtxH	<1293..1347	CDD:295162	7/58 (12%)
		AAA_12	1435..1626	CDD:289832	60/228 (26%)
mov10a	XP_002662576.2	P-loop_NTPase	517..>709	CDD:304359	62/277 (22%)
		AAA_11	517..704	CDD:289831	60/272 (22%)
		DNA2	<634..963	CDD:224037	90/376 (24%)
		AAA_12	711..934	CDD:289832	61/229 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810