DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and setx

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_005161583.1	Gene:	setx / 562474	ZFINID:	ZDB-GENE-070402-1	Length:	2368	Species:	Danio rerio

Alignment Length:	1831	Identity:	422/1831 - (23%)
Similarity:	694/1831 - (37%)	Gaps:	499/1831 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PAVRCPTGT--QPTEFNLKQQIPNFGGKQDPGQEEEVLPSSSNLHLPKLTEVKQEIV------KH 189
            |:|...|.|  .....::.||      ::||    |..||       :...:|:|.:      ..
Zfish   617 PSVEAATNTVVSRNSVSICQQ------QEDP----EAGPS-------RAAFIKEEPLWNYGKKSF 664

  Fly   190 TSEEI----QNIF---GEPSDAILNSVLELNPYLYNKLTNKTANNEITRKKIHDGDCIELDTD-T 246
            ::||.    :::|   .||||.:|  :.||.|.:           |:|..|...|...|:.:. .
Zfish   665 SNEEFSCGPEDVFKGKKEPSDPVL--ISELRPAV-----------ELTNIKPDLGKLQEIRSRLN 716

  Fly   247 DRRSISE----AQKAEDPSA------------EREVDDEEEYDESFAMSQAVIREMKAEMH---V 292
            |.:|:|:    |:|..|.||            |.|.||:::.|:...:.....|.:|:.:|   .
Zfish   717 DDQSLSKIEAIARKKSDVSAKKRPGFGALKNEEEEEDDDDDDDDDEPLHITRTRLIKSAIHKLES 781

  Fly   293 SDGEEDFLLTNGMGNLPEGSPSNQAYDDIVYVSDSDDD----------ELYDKVADWSKLLSQKV 347
            ||.:.|...|..    ...|..|.....||...|.|.|          ..|.:....:|.....|
Zfish   782 SDSDVDSRATAS----SVISKQNTESTTIVISDDEDSDNDIRPNDPLRSSYKECTVKNKSPESPV 842

  Fly   348 VP-------DVIEMSQTYPLENEH------KDSDSDLDIGAK--KPKRTLRIS------------ 385
            :|       |.:..||.:..|.:.      .::|.|..:..|  |..|.|:..
Zfish   843 MPESPGRDYDDLSESQVFEFETQQYVASAWDNADLDGSVLTKNLKSDRILKPQLDETPNEASPSW 907

  Fly   386 SSSDEDSADEVI---VHQTKQKGRRSKSKSPNDHVVRQADSTTPDLPAVRKLSVSSIDSVYENKQ 447
            ||..|...||.|   ..|.::|.|:.:.:.|.|.:.|               ....::.....:|
Zfish   908 SSETELVPDEDIERACQQAEEKIRQQQPRKPADEMER---------------DYKQVEEKIRPQQ 957

  Fly   448 TKLN-------SKLKSCLKS--------PTKTSVDNMENMTETKSCSNRQREQIVASRNEPTNIC 497
            |:.|       ||..|..||        |.||.|        ||:..:.:|:.:...:....:..
Zfish   958 TRENSDVHEFSSKASSTTKSWDKFAKPKPLKTKV--------TKTTPSDKRDHLQVKKPVLIDAL 1014

  Fly   498 PQKIE----------------TNKTSTRKRFVSTTSRDELSTTSKEIKDAPKNN----------- 535
            .|||.                ::.|:.....||:||....|::|     .|.::
Zfish  1015 AQKIRRHPWKRSSTSEDMEEPSSSTTPSSSAVSSTSSSSSSSSS-----TPSSSSITSPYFSAST 1074

  Fly   536 ------VEPPKKMLRSRSKSCYIDRPVELDEHITKNEVPLKKK-YESVDNSKEELIVTLEAPAML 593
                  :.||||:.:       |..|     ..|...:.|||| .::.|.|:.    :|:..|.|
Zfish  1075 SRGTPAIVPPKKVRK-------IAEP-----ESTAERLGLKKKERKAFDLSQR----SLDCVARL 1123

  Fly   594 TTPTKSKTQCVKKKATQTRGR-RKTIHSRDEIRSLTAEAEENKKISPA------KQTNEEIPIPT 651
                :...|.|:.:..|.|.| .:|..:..:.|.:.|    |||:..:      :|:.|:...|.
Zfish  1124 ----RCHGQNVQVEPHQKRRRASRTSKTSPQKRMVKA----NKKLMGSQDIQFFRQSREKHQKPA 1180

  Fly   652 KSPLKRNA-RLLNRSKSCYMDRLVISETED----PAKKVIKDISPTKSDTTDNVLNFVDVRQTRG 711
            ..|:..:| :.::|....:..|..|...||    |..:      |......||....:....:.|
Zfish  1181 TEPITTSASKPVSRQDELHSSRPTIPNNEDGDFLPCPQ------PDAHCQQDNEKGALGSSDSSG 1239

  Fly   712 PSV----IEAPSLPKNRGKLRGVSAEVKVKDKVLDRQRFIDYQAEMNAKWKQKPKDKKKEDEKLK 772
            ..|    ::|....:  |.|.|..|....|:.|.|...|.......:.:...:.::.:.|:::|.
Zfish  1240 DGVGNKFLQASEAAE--GNLEGEKAAQASKEDVDDEWMFYTQMEPTDMEICSQMEEFEDENDELF 1302

  Fly   773 ECRREAL--------------------KKLSEKPKENSH-------RSTTNKRKNPTSVPTVQNT 810
            ..:|:.:                    |.:......|.|       ...:.|:..|::......:
Zfish  1303 LTQRDPVDMDIDTDSGSDTPGQPDFTDKNVPPSNAANDHLFLKPGMSPMSQKKAKPSTTKIYTPS 1367

  Fly   811 NRGGFLT----KGVDGPAP------KLAKTDNAKPPPKKPVPKQPPAIETFSQQLQAADKAVLHP 865
            :|...|.    ||...|.|      |:.:..:|.|||..|.||.||  ....|.|         |
Zfish  1368 SRSASLVLEMEKGAKPPPPANVAKAKIPRLASAMPPPAMPPPKMPP--PKMFQPL---------P 1421

  Fly   866 QPQCSRPVERKEAELARNQ----RTCNKVTFAEMELYHQKAEDSKKLQKKLRKVHFNDDVKVHCI 926
            .||..:|...|:..|.:..    .|.||::...
Zfish  1422 PPQLPKPPALKQVTLPQGSVPKLVTSNKISSTS-------------------------------- 1454

  Fly   927 ERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPVN------------DIRQHSRSILKWAN 979
               :..|.||..|.|.                ..|||||            |:...:::||||..
Zfish  1455 ---EPPSYKVYQRPEA----------------PVNKPVNKPMPTMDQSPKFDLSVLTQAILKWEY 1500

  Fly   980 QWLKH----GS-VDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDY---------- 1029
            :.|.:    || :|..  |..|..:|..|.|:..|.....||:.:.....:..::
Zfish  1501 RMLDNYKAFGSPLDLC--QLPLKEVPVNFSSYLEYFNTLYPLLLINAFEEMANEWLKEGRVKLYL 1563

  Fly  1030 KIN----NKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELK--- 1087
            |:.    :..|.|.|.|...:|: |.  |.::..|.....:|:.....|...:...|..:|.
Zfish  1564 KVQGIEYSNRTASASFIAGLSQE-CD--VKQIYPKEDDLVLLWLPDNTGAYAQDEPNFHDLHPHF 1625

  Fly  1088 -FVS-GNVFDLT-FEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQ-------LRSSP 1142
             :|| .||.:.| ......:::.:...|:..:.::||:..:   :|:|.::.:       ||:.|
Zfish  1626 GYVSRSNVLNRTPGSRSTLNLTIQTRGNVSSVNSQPVLCEV---VGSLISIFREFRALCLLRNGP 1687

  Fly  1143 LCRRILKP-----TQTVNEVSLPKQPFTFKGCHKLNEHQENIV------LHTYQRIIDDLQPSLT 1196
            :.|.:|.|     |.:::..|....|       :.|..|...:      :|..|:     .|...
Zfish  1688 MLRPLLAPHVSFFTHSLDGPSDLDAP-------EFNRDQARAIACGIAMIHRKQK-----TPKFL 1740

  Fly  1197 LIQGPPGTGKSRVISELCLQTL---------YGNA-AKTLDRKILICAHSNTAVDHIVGLLGSVL 1251
            ||.||||||||:.|..|..:.|         .||. :|:...::|:||.||.|:|   .|:..|:
Zfish  1741 LIHGPPGTGKSKTIGGLLYKLLSSATNSSATVGNLHSKSRRTRVLLCAPSNAAID---SLMKKVI 1802

  Fly  1252 RVM------------NRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKK 1304
            .:.            |....:|:|.|....:|...:||||: |..||:.|:.|:..:.:....|:
Zfish  1803 LIFKEKCRNINAPQGNCGDINLVRLGNERTISKSLKPFSLD-HQTKARAQRAQQTVESDVHRRKE 1866

  Fly  1305 QHNDLKDEIQQLKEKTNLTST---YLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRAN 1366
            |.:.:.:.:.....||...||   .||:|.:|..|:.:.:|.|:.....:|:|.:.  :.:..|:
Zfish  1867 QLDQMIENLSHQCAKTQKNSTEFKNLLEQKKQFLKEREGLSRQIKECRGRRQESQA--LVLQNAH 1929

  Fly  1367 IICTTLSS--CVKLANYV-----DFFDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQLPAV 1424
            :||.|||:  .:.|.|..     :.|...|:|||:|..|..||:||.:....::||||..|||..
Zfish  1930 VICCTLSTSGSIVLENAFRRLGHEPFSCVIIDEASQAKETETLIPMLYRCPSVILVGDPNQLPPT 1994

  Fly  1425 VLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKL---FKLSTQYRMHPEICRWPNQYFY 1486
            |:|:||.:||...|:..|:.:||          |..::||   ..||.||||||:||.:|::|.|
Zfish  1995 VVSQKAKEFGFDQSLMARLCKSL----------HPSNSKLPPILLLSMQYRMHPDICEFPSKYIY 2049

  Fly  1487 EDQLIN----AECTARFASPLIPYCVINLKYTCDSNGAQNK---SISNNEEARFVAKLLTEMDKH 1544
            ...|.|    |:.....:.|..||.|.::     .:|.:.|   |..|::|...|..||..:.|.
Zfish  2050 NSALKNDCETAQKRCSLSWPFKPYKVFDV-----MDGRETKERDSFINHKEVSLVGLLLKLLCKE 2109

  Fly  1545 MPSKRFSYGLISPYQNQCYALSQVIPS-----HMNITPQTVDSYQGLEKDVIIISNARTR----G 1600
            ...:   .|:|:||..|.:.:...|.:     .:.:...|||.:||.|.|.||:|..|..    .
Zfish  2110 QAVR---VGVITPYNAQKHRILDAIKTSGINKQLQVEVDTVDGFQGREMDCIIVSCVRASSEMGS 2171

  Fly  1601 CGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFN------------LD 1653
            .||:.|.||:||.:||.:..|.|.|:...|:....|..|::||.:|:...|            :.
Zfish  2172 IGFVGNRQRMNVTITRAKFSLFILGHLRTLREQSDWGALIEDAGRRECIINTMQKNFESDVKKIV 2236

  Fly  1654 RDDVNDLDRSL 1664
            :...|.|.|||
Zfish  2237 KQKPNPLSRSL 2247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	86/294 (29%)
		AAA_19	1194..1251	CDD:289986	24/66 (36%)
		YtxH	<1293..1347	CDD:295162	13/56 (23%)
		AAA_12	1435..1626	CDD:289832	64/209 (31%)
setx	XP_005161583.1	SEN1_N	37..>322	CDD:289496
		AAA_11	1714..1998	CDD:289831	86/294 (29%)
		AAA_12	2005..2197	CDD:289832	64/209 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6681
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3289
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101455
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.870