DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7504 and helz2a

DIOPT Version :9

Sequence 1:NP_001137907.1 Gene:CG7504 / 38904 FlyBaseID:FBgn0035842 Length:1676 Species:Drosophila melanogaster
Sequence 2:XP_003198895.2 Gene:helz2a / 562461 ZFINID:ZDB-GENE-120920-1 Length:2656 Species:Danio rerio


Alignment Length:1880 Identity:401/1880 - (21%)
Similarity:663/1880 - (35%) Gaps:594/1880 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSSVWYLEHVTTGARLILHNGTNLMGRHSRCRIILGGQYQFVSREHANIIVSEKGVEVESLNPLN 65
            ::.|:|.|.:.|.:.:           |.:|.|:..|    ..|.:|..: .|..:.::.....|
Zfish  1125 VAEVYYEEPMFTSSTV-----------HKQCEIVKEG----YDRGYAKPL-DESTLRIDIKGRAN 1173

  Fly    66 GLFINGGKLGDKINRLAVAEGSTISLGVTGVNLNEITGIHAIFILKKKEPVVEEIVLSSDDDDTT 130
               |.....|||:....::..|...:|            ..|.||:..:.|.|.:......|:..
Zfish  1174 ---IGRAFPGDKVTVEILSATSHPPMG------------RVINILESADTVKEFVCALERHDNQV 1223

  Fly   131 PLPAVRCPTGTQPTEFNLKQQIPNFGGKQDPGQEEEVLPSSSNLHLPKLTEVKQE-------IVK 188
            ..|..:|.|......:..|   ||....::|          .:|.:.|..::.:|       |||
Zfish  1224 MTPINKCITKIFTPFWKDK---PNHIAVRNP----------ESLKVEKFIKINEEAHRKSLFIVK 1275

  Fly   189 HTSEEIQNIFGEPSDAILNSVLELNPYLYNKLTNKTANNEITRKKIHDG-DCIELDTDTDRRSIS 252
            ..|  .:|:|..|    |..|:.:.|        |.|.       :.|| ..:.::... ||::|
Zfish  1276 VLS--WRNVFRYP----LGIVVGVLP--------KIAT-------LDDGLHVLSIEYQL-RRTLS 1318

  Fly   253 EAQKAEDPSAER-EVDDEEEYD----ESFAMSQAVIREMKAEMHVSD-GEEDFLLTNGMGNLPEG 311
            .:.:.:....:| ::.::...|    .:|.:..|..:::...:.:.| ||               
Zfish  1319 SSLRKQMQYLQRLDIFEKGRRDFRMLPTFTVDPAHSQDLDDAISLQDFGE--------------- 1368

  Fly   312 SPSNQAYDDI-VYVSD-----SDDDELYDKVADWSKLLSQKVVPDVIEMSQTYPLENEHKDSDSD 370
                  |.:| |::||     :.|.|| ||.|   :.|.....|...|....:|.|.    |.:.
Zfish  1369 ------YLEIGVHISDVASFVAKDSEL-DKFA---RQLCTTFYPREKEPIYMFPKEL----STNL 1419

  Fly   371 LDIGAKKPKRTLRISSSSDEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPDLPAVRKLS 435
            |.:...:.:|.:.:....|.         ||.:..||...||.              :.:.||.|
Zfish  1420 LSLIPNQDRRAISLIIEVDA---------QTNRIKRRFICKSV--------------IHSNRKFS 1461

  Fly   436 VSSIDSVYENKQTKLNSKLKSCLKSPTKTSVDNMENMTETKSCSNRQREQIVASRNEPTNICPQK 500
            ...::.:.||.: .|:..|:.||   .|.|     |..|.   ..|.|:|        .:.|.:.
Zfish  1462 YDEVEDILENGE-PLSDLLEICL---VKVS-----NFAEV---HRRYRKQ--------DDWCYKM 1506

  Fly   501 IETNKTSTRKRFVSTTSRDEL------STTSKEIKDAPKNNVEPPKKMLRSRSKSCYIDRPV--E 557
            .:.:.|..|:|  |....:||      ....:.:.|....:..|    ||.:      |||.  :
Zfish  1507 PDEDVTLGRRR--SHQMVEELMVMFNHMVAERLLSDGATRSKTP----LRCQ------DRPQTDK 1559

  Fly   558 LDEHITKNE--VPLKKKYESV--DNSKEELIVTLEAPAMLTTPT-KSKTQCVKKKATQTRGRRKT 617
            |.|...||.  :||...:.|.  :.:|:.||.........|.|. ||..:|:|.           
Zfish  1560 LIEIFDKNAALIPLSVHFSSQAHELNKQGLIQHNPQTDSDTFPVLKSILRCLKS----------- 1613

  Fly   618 IHSRDEIRSLTAEAEENKKISPAKQTNEEIP--IPTKSPLKR--NARLLNRSKSCYMDRL----- 673
                      .||.|...||.....|::..|  :|.....:|  :...:.||.|.::.|:     
Zfish  1614 ----------AAEQENIYKIIDFVATDDIHPQLLPFAVAFRRLFHKACIQRSNSTHVSRIGHYDL 1668

  Fly   674 -VISET--EDPAKK----VIKDISPTKSDTTDNVLNFVDV--------RQTRGPSVIEAPSLPKN 723
             :.|.|  ..|.::    :::.:..:..|.||.....:|:        |:....|..|.      
Zfish  1669 DLDSYTWASSPVRRYLDVIVQRLLHSVIDKTDVKYTTLDINLSCLEFSRKNDQQSAYER------ 1727

  Fly   724 RGKLRGVSAEVKVKDKVLDRQRFIDYQAEMN---AKWKQK-PKDKKKEDEKLKECRREALKKLSE 784
              |...:...:|:..:   .:|.:.|..|:|   ..:|.. |.::....|.|....|:.|  |:.
Zfish  1728 --KANALHFALKLSSQ---SERKVAYIVELNPLGTNFKVSFPLNRSSISENLDIMSRDLL--LAV 1785

  Fly   785 KPK-------------------ENSHRSTTNKRKNPTSV-------------------------P 805
            :|:                   .|||.....|::||.||                         |
Zfish  1786 QPEFDVTNNSMILKWERRIYSFSNSHIHAEVKQQNPNSVMAYVPAKTWKCIADAIREQNWNAIFP 1850

  Fly   806 TVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPKQPPAIETFSQQLQAADKAVLHPQPQCS 870
            .::...|    ..|::  |.:..:|.:|....|...|            |.|...|.|:.:.:..
Zfish  1851 LIEELQR----NSGIN--ARQFHETLSASKCTKNYDP------------LHAEHYAELYLRIKQG 1897

  Fly   871 RPVE-RKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKKLRKVHFNDDVKVHCIERVKGASS 934
            ..|| :..|..||...|.:    .::.:.|.|.|        :...|..|.||  |......:||
Zfish  1898 EAVEVQLGASTARGLMTPS----IQLFVVHPKFE--------ICVEHVRDPVK--CFSEYALSSS 1948

  Fly   935 KVQGRKECIKLRLSSYRERRE----WIRRENKPVNDIRQHSRSI------------LKWAN---- 979
            :            |||...::    |     :|:.::...|.::            |||.|    
Zfish  1949 R------------SSYNLYKDYQAIW-----RPMCEMESASSAVAENESILIVDVPLKWENSNPK 1996

  Fly   980 --------------QWLKHGSVDAVAEQDVL-------MPIPPEFDSFKNYREIFVPLMKLELLS 1023
                          ||    |:|.......|       ....|..:|.:|     ..||.:...:
Zfish  1997 RLQGFFLLPLDKKSQW----SIDCDLRNSFLCIRTRIQKQSSPFLESAQN-----TALMDIPSFT 2052

  Fly  1024 TIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELKF 1088
            .:........:.|.|....|.|.:.:  |:...:|..|                  ..|:.|..|
Zfish  2053 WVVHGVITEAEETESKESTNQEPKSL--RIDFLINHMP------------------MTNIPEQIF 2097

  Fly  1089 VSGNVFDLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKPTQT 1153
            .....|  |.|::.:.:.:.:.:|        .:|||                      .|..|.
Zfish  2098 HERTRF--TLELIPKLLPDVRKEN--------AIDSL----------------------TKANQL 2130

  Fly  1154 VNEVSLPKQPFTFKGCHKLNEHQENIVLHTY-------------QRIIDDLQPSLTLIQGPPGTG 1205
            |..:::.::..:.:||...|::.....:::|             :.|.:.|....||||||||||
Zfish  2131 VKNIAMGRRITSDRGCKIPNQNTGRFEINSYHPSGLSHLNNSQSKAIREALTNPFTLIQGPPGTG 2195

  Fly  1206 KSRVISELCLQTLYGN-----AAKTLDRKILICAHSNTAVDHIVGLLGSV------LRVMNRDQF 1259
            |: |:....|..|:.|     |:.:..|.||.|..||.:||.:.|.|..:      |||.: ||.
Zfish  2196 KT-VVGVHILYWLHKNIQQLQASGSKKRAILYCGPSNKSVDVVAGHLLHLRDHLKPLRVYS-DQM 2258

  Fly  1260 HLLRF---GMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAE--------ILKKQHNDLKDEI 1313
            .:|.|   |.:.|:|..|:                 |..|.|.|        :::|:.|....:|
Zfish  2259 EMLEFPYPGCNLKLSRNSK-----------------RGEKPNTELSSIALHHLIRKEGNPFSTQI 2306

  Fly  1314 QQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICT-TLSSCVK 1377
            :....|....     .||..:|:||      ....|.:..:.|:.|..|    |:|| |.:|...
Zfish  2307 RAFDMKVQRG-----DQLTDEERKL------FREILKKARKHELLHHDV----ILCTCTAASHPA 2356

  Fly  1378 LANYVDFFDICIVDEATQCTEPWTLLPMRFGLTH----MVLVGDMQQLPAVVLSKKAIDFGLSNS 1438
            ||..:||..| |:||....|||...:|:   :.|    :||:||.:||..||..:.|...|:|.|
Zfish  2357 LAETLDFKQI-IIDECAMATEPEAFIPL---VAHKPEQIVLLGDHKQLQPVVHCEVAERLGMSRS 2417

  Fly  1439 MFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQL---INAECTARFA 1500
            :|:|...:.           ||      |.|||||..:||.:|:..||..:|   |.|:      
Zfish  2418 LFERYMENA-----------LM------LDTQYRMQEDICAFPSNEFYGGRLQTGIPAK------ 2459

  Fly  1501 SPLIPYCVINLKYTC----------------DSNGAQNKSISNNEEARFVAK---LLTEMDKHMP 1546
            |.|.   :...|.||                ...|.:| |.:|.|||..|.:   ||||..    
Zfish  2460 SKLF---LTQTKQTCIVFGHVEGKEKSLVVRTEQGNEN-SKANMEEAEEVVRVAILLTEAG---- 2516

  Fly  1547 SKRFSYGLISPYQNQCYALSQVIPSHMN----ITPQTVDSYQGLEKDVIIISNART--------- 1598
            .|.....:::||..|...:|:.:  |.|    ||..|:...||.|...:|:|..|:         
Zfish  2517 IKTKDIAILTPYNAQVAKISESL--HNNHIRDITVNTIMRSQGSEWRYVIMSTVRSCPKSEIETQ 2579

  Fly  1599 -------RGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFN 1651
                   :..||:|:..::||.:||.:..|.|.||...|:...:||.||:..:::....|
Zfish  2580 PPKSWIMKRLGFITDPHQVNVGITRAQEGLCIIGNENLLRCSSLWRKLLNHYQEKGCVVN 2639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7504NP_001137907.1 FHA 4..96 CDD:238017 18/91 (20%)
FHA <10..101 CDD:224630 15/90 (17%)
AAA_11 1171..1428 CDD:289831 84/296 (28%)
AAA_19 1194..1251 CDD:289986 26/67 (39%)
YtxH <1293..1347 CDD:295162 13/61 (21%)
AAA_12 1435..1626 CDD:289832 62/232 (27%)
helz2aXP_003198895.2 AAA_11 614..807 CDD:289831
P-loop_NTPase 639..>683 CDD:304359
DNA2 <741..1055 CDD:224037
UvrD_C_2 817..1017 CDD:304668
RNB 1338..1698 CDD:214935 94/464 (20%)
AAA_11 2168..2405 CDD:289831 81/274 (30%)
AAA_19 2176..2246 CDD:289986 28/70 (40%)
P-loop_NTPase <2366..2438 CDD:304359 31/92 (34%)
AAA_12 2414..2614 CDD:289832 62/232 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170581694
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.740

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