DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and dna2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_021329958.1	Gene:	dna2 / 559535	ZFINID:	ZDB-GENE-090313-71	Length:	1374	Species:	Danio rerio

Alignment Length:	1596	Identity:	328/1596 - (20%)
Similarity:	545/1596 - (34%)	Gaps:	500/1596 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 DPSAEREVDD----EEEYDESFAMSQAVIREMKAEMH--VSDGEEDFLLTNGMGNLPEGSPSNQA 317
            :|||..|..|    |...|.||            |.|  ||.|    |.|.|:    .|.||.:|
Zfish    64 NPSAVPETPDSLRIERPSDTSF------------EKHSPVSRG----LHTKGV----RGKPSLKA 108

  Fly   318 YDDIVYVSDSDDDELYDKVADWSKLLSQKVVPDVIEMSQTYPLENEHKDSDSDLDIGAKKPKRTL 382
                                  .||| |......:|...|:..:|....|.|        .||
Zfish   109 ----------------------RKLL-QPQKSSSLESEDTFEFKNGISHSGS--------VKR-- 140

  Fly   383 RISSSSDEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPDLPAVRKLSVSSIDSVYENKQ 447
                          ::|.|:......||::..|..:.....::.              :..:||.
Zfish   141 --------------LLHSTENIQSAKKSRTTQDQKITDCGPSSA--------------TASQNKY 177

  Fly   448 TKLNSKLKSCLKSPTKTSVDNMENMTETKSCS---NRQREQIVASRNEPTNICPQKIETNKTSTR 509
            ::...|..|  |||        |...:|:|.|   :|.:.......||..|      ..:|.|.|
Zfish   178 SETLQKAFS--KSP--------EKKIKTESVSLEGSRLKAGPCLKMNEKLN------GFSKDSGR 226

  Fly   510 KRFVSTTSRDELSTTSKEIKDAPKNNVEPPKKMLRSRSKSCYIDRPVELDEHITKNEVPLKKKYE 574
                   |...||.::.|.:::|                :|.:....::......|:..|...|.
Zfish   227 -------SSHHLSFSTSEKENSP----------------TCNVKSEADMGAVSGTNDFDLVMSYS 268

  Fly   575 S-VDN-SKEELIVTLEAPAMLTTPTKSKTQCVKKKATQTRGRRKTIHSRDEIRSL---------- 627
            | :.| |.||....|..|.....|..:....||::...  |:...:...|:...|
Zfish   269 SWIQNGSTEEKGTFLNCPIAKKRPLNTSELQVKEQIAD--GKTLPVPFEDDFADLMDDWFDEGME 331

  Fly   628 -TAEAEENKKISPAKQTNEEIP--IPTKSPLKRNARLLN-----RSKSCYMDRLVI--SETEDPA 682
             .:||.:.||.|..|  |:.||  :...|.:.....:|:     .|:||....|.|  |:|....
Zfish   332 QKSEAPKPKKFSHEK--NKGIPEHVVLASGVHNRYWVLDVQDVTSSRSCSEKHLTITCSKTSQAT 394

  Fly   683 KKVIKDISPTKSDTTDNVLNFVDVRQTRGPSV--------------------IEAPSLPKN-RGK 726
            :..|     .|......::...|:....|..|                    |...|:..: |..
Zfish   395 ETCI-----LKDGWESTLVTVGDIIHLEGKCVSGLWTIDRDSAFLILLPDLLISGTSIASSIRCM 454

  Fly   727 LRGVSAEV---------------------------------KVKDKVLDRQRFIDYQAEMNAKWK 758
            .|||..|:                                 |::....:..|..:|..:|.: .|
Zfish   455 RRGVLGEMFKAFDGGSKQMLNGTIVHDIFQKAAMSSDFSSEKIQTFATEALRSPNYLGQMYS-LK 518

  Fly   759 QKPKDKKKEDEKLKECRREALKKLSEKPKENSHRSTTNKRKNPT-SVP-----TVQNTNRGGFLT 817
            ....|.::|.|       |.|..:||..|:..|.|....:|..| .:|     :.|:.:....:|
Zfish   519 LTQADMRQEVE-------EYLPSISEWAKQYLHTSPQAGQKQLTLKLPSDGALSKQDASSSVMVT 576

  Fly   818 KGVD----------GPAPKLAKTDNAK------PPPKKPVP------KQPPAIETFSQQL----- 855
            ..||          |...|:..|...|      .|.::.||      |:..:||..||.:
Zfish   577 DFVDIEENIWCPRFGLKGKIDVTAGVKIHRRGRKPMERIVPLELKTGKESNSIEHRSQVILYTLM 641

  Fly   856 ---QAADKAV----------LHPQPQCSRPVERKEAELARNQ----------RTCNKVTFAEMEL 897
               :..|...          ||  |.....::|:|....||.          :...|...|::..
Zfish   642 SSARRCDPEAGFLVYLKTGSLH--PVVGNHMDRRELIKIRNSLAHHIGNNLIKVDGKSQMAQLPA 704

  Fly   898 YHQKAEDSKKLQKKLRKVHFNDDVKVHCIER--VKGASSKVQGRKECIKLRLSSYRERREWIRRE 960
            .....:..|...:|.....:|     ..:||  |:..|...|.                 :::.|
Zfish   705 IVSDQQTCKYCPQKRNCAIYN-----RAVERDPVEKCSENPQA-----------------FVQSE 747

  Fly   961 NKPVNDIRQHSRSILKWANQWLKHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTI 1025
            ::.::.:.      |::.:.||...|::|:.           .::....|.|:        |.|.
Zfish   748 SEHLSQVH------LQYFSHWLLLCSLEALT-----------MENKGGRRNIW--------LQTA 787

  Fly  1026 ERDYKI-----NNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLE 1085
            ::..||     |.:....||:::    |..|:   ....:..|:..|..|.....:..:..:.:.
Zfish   788 QQREKIGGCAGNMRLAGGVSILS----DGVYK---HSFERKEGEQTLTGLIVGDRIVVSDQDSVL 845

  Fly  1086 LKFVSGNVFDLTFE----ILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRR 1146
            :...:|.|.::...    .|.:::|:.....:.:|........|...||.||.:  :.::|...|
Zfish   846 IGLSTGYVTEIAVNRVTCSLDKNLSKYSSNTVFRLDQDEGAGGLSTHLGNLSML--MENTPTSER 908

  Fly  1147 I------LKPTQTVNEVS--LPKQ-----PFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLI 1198
            :      .:|.|.::.:|  ||:.     ....||.:|..:.....||         |....|||
Zfish   909 LRELIVEFRPPQFIDSLSSVLPRDAKDIVSNILKGLNKPQKQAMKKVL---------LSKDYTLI 964

  Fly  1199 QGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLR 1263
            .|.|||||:..|..| ::.|:     .....:|:.:::::|||:|       |..:.|.:...||
Zfish   965 VGMPGTGKTTTICTL-VRILH-----ACGFSVLLTSYTHSAVDNI-------LLKLKRFKIGFLR 1016

  Fly  1264 FGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLL 1328
            .|..:|:.|...||:.||...|.                          ||.|:|         |
Zfish  1017 LGRPQKVHHEILPFTEEACRAKG--------------------------IQTLEE---------L 1046

  Fly  1329 QQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLANYVDFFDICIVDEA 1393
            :||..:|..:......:..|:..|..                              ||.||||||
Zfish  1047 EQLYSRELIVATTCMGVKHPIFSRRR------------------------------FDFCIVDEA 1081

  Fly  1394 TQCTEPWTLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYH 1458
            :|.::|..:.|: |.....|||||.||||.:|.:.:|...|:..|:|.|::            :|
Zfish  1082 SQISQPVCIGPL-FYAQRFVLVGDHQQLPPIVQNAEARSLGMDESLFKRLE------------HH 1133

  Fly  1459 LMHTKLFKLSTQYRMHPEICRWPNQYFYEDQL-----------------INAE-------CTARF 1499
              ...:.:|:.||||:..|....|...||.:|                 ..||       |..::
Zfish  1134 --RDAVVQLNVQYRMNSAIMSLSNALMYEGRLECGSEKTANAVLQLPSRAQAEEELELYVCQPQY 1196

  Fly  1500 AS-------PLIPYCVINLKYTCDSNGAQNKSISNNEEARFVAKLLTEMDKHMPSKRFSYGLISP 1557
            ::       |..|.|.::..........:...|||:.||..|..|:|.:.| ...:....|:|:|
Zfish  1197 SAWVQAALEPNSPVCFLDTSEVPAPETVEKSGISNHTEAVLVQGLVTLLLK-AGCRACDIGVIAP 1260

  Fly  1558 YQNQCYALSQVI--PSHMNITPQTVDSYQGLEKDVIIISNARTRGCG----FLTNYQRLNVALTR 1616
            |:.|...:|.::  .:...:...|||.|||.:|.|||:|..|:...|    .|.:::|||||:||
Zfish  1261 YRQQLKVISSLLQGDAFKALEVNTVDKYQGRDKSVIIVSFVRSNAEGNLGELLQDWRRLNVAITR 1325

  Fly  1617 PRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFNL 1652
            .:..|::.|:...|:.......||...::..:.|.|
Zfish  1326 AKHKLLMLGSAPTLRRYAPLEKLLCHLQQEDMIFQL 1361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	65/256 (25%)
		AAA_19	1194..1251	CDD:289986	17/56 (30%)
		YtxH	<1293..1347	CDD:295162	8/53 (15%)
		AAA_12	1435..1626	CDD:289832	57/227 (25%)
dna2	XP_021329958.1	Dna2	391..602	CDD:312281	37/223 (17%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<579..721	CDD:321087	26/143 (18%)
		AAA_11	788..1354	CDD:331082	157/677 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910