DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7504 and ighmbp2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_001038365.1	Gene:	ighmbp2 / 556484	ZFINID:	ZDB-GENE-050419-258	Length:	997	Species:	Danio rerio

Alignment Length:	691	Identity:	168/691 - (24%)
Similarity:	286/691 - (41%)	Gaps:	143/691 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1019 LELLSTIERDYKINNKNTF--SVSLINVETQDMCYRLVTRVNSKPFGKF-----VLYTLYCCGM- 1075
            ||||.. ||:.::.....:  :|||.|::.:.:|. :..::.|:..|.:     :.....|.|:
Zfish    11 LELLQE-EREAELEETRAWQENVSLKNLQHKGVCL-MKLQIGSQHTGMYGRLLVIFEPRKCIGLS 73

  Fly  1076 --------------LKETFANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTARPVVDSLR 1126
                          |.:.....|..:..||.|...|...|.....:.:             |...
Zfish    74 VLPSNTFGPGDIIGLYQAEGQALPTQLGSGVVTRATQASLTVAFDDTQ-------------DGTN 125

  Fly  1127 VELGALSAVHQLRSSPLCRRILKPTQTVNEVSLPKQPFTFKGCHKLNEHQENIVLHTY-----QR 1186
            ::...|..:.:|.:....||:....:::|..|  ..|.:..........|..|:.|.|     ..
Zfish   126 LDRDGLYNLMKLANDVTYRRLSSALKSLNGYS--NGPASHLISVLFGYSQPGILSHLYALEFNNT 188

  Fly  1187 IIDD----------LQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHSNTAVD 1241
            .:||          .|..:.:|.|||||||:..:.|:.||      |....:|:|.||.||.|||
Zfish   189 KLDDSQKEAVSFAISQKDVAIIHGPPGTGKTTTVVEVILQ------AVKQQQKVLCCAPSNVAVD 247

  Fly  1242 HIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQH 1306
            ::|..|.       :::..:||.|...::....:..||:|..          ...:|..|:....
Zfish   248 NLVERLA-------KNKVKVLRLGHPARLLESIQKHSLDAVL----------AHSDNTNIISDIR 295

  Fly  1307 NDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTT 1371
            .|:.....::|:..:          :.:...|:....:|...|..|||..||.: :.||::|..|
Zfish   296 KDMDKAFNEIKKARD----------KGQRSNLRREIGELRRELRTREETAISQI-LKRADVILAT 349

  Fly  1372 LSSC------VKLANYVDFFDICIVDEATQCTEP--W-TLLPMRFGLTHMVLVGDMQQLPAVVLS 1427
            .:..      ..|.|  |.||:.::||..|..|.  | .||..|    ..:|.||.:|||..:.|
Zfish   350 NTGASDDGPLKHLPN--DHFDLVVIDECAQALESSCWIALLKAR----KCILAGDYKQLPPTIKS 408

  Fly  1428 KKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLI- 1491
            :.|...|||.|:.:|:       :.|.|.     :.:..|:|||||:..|.:|.::..|:.:||
Zfish   409 QSAASKGLSVSLMERL-------IKKYGD-----SVVRMLTTQYRMNSAIMQWASEQMYQGKLIA 461

  Fly  1492 ----------NAECTARFASPLIPYCVINLKYTCDSNGAQN---KSISNNEEARFVA---KLLTE 1540
                      :....|......||..:::.. .|..|..:|   :|..|..|...||   |.|||
Zfish   462 HPSVEKHLLRDLAGVADVEETRIPLLLVDTA-GCGLNEMENTDEQSKGNQGEVDIVALHIKALTE 525

  Fly  1541 MDKHMPSKRFSYGLISPYQNQCYALSQVIPSH--MNITPQTVDSYQGLEKDVIIISNART--RG- 1600
            ....:.    ...:|:||..|...|.|.: ||  ..:..::||.:||.||:.:::|..|:  :|
Zfish   526 AGVQVK----DIAIIAPYNLQVDLLRQKL-SHKYAELEIKSVDGFQGREKEAVVLSLVRSNRKGE 585

  Fly  1601 CGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLD 1641
            .|||...:|:|||:||.||.||:..:.:.:::.:..::|:|
Zfish   586 VGFLAEDRRINVAVTRARRQLVVVCDSQTVRNHDFLKSLVD 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	71/280 (25%)
		AAA_19	1194..1251	CDD:289986	23/56 (41%)
		YtxH	<1293..1347	CDD:295162	6/53 (11%)
		AAA_12	1435..1626	CDD:289832	62/212 (29%)
ighmbp2	NP_001038365.1	TIGR00376	25..639	CDD:273041	162/676 (24%)
		AAA_19	196..254	CDD:289986	23/63 (37%)
		AAA_12	416..612	CDD:289832	62/213 (29%)
		R3H_Smubp-2_like	719..778	CDD:100070
		zf-AN1	901..937	CDD:279736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810