DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7504 and mov10b.2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_001037805.1	Gene:	mov10b.2 / 555950	ZFINID:	ZDB-GENE-060526-371	Length:	1015	Species:	Danio rerio

Alignment Length:	746	Identity:	178/746 - (23%)
Similarity:	279/746 - (37%)	Gaps:	203/746 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   996 LMPIPPEFDSFKNYREIFVPLMKLELLS-------------TIERDYKINNKNTFSVSLINV-ET 1046
            |:..|..||   ||.|.|..|:.||...             |:.||   .:|....::|..| |.
Zfish   360 LLQSPLTFD---NYAERFDLLLYLEECQMHVDIKRYNKDSVTLHRD---RDKRLMGLNLPGVSEN 418

  Fly  1047 QDMCYR----LVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFEILKQDISE 1107
            :....|    |:|:.....|.....|         :.:.:.:||..|.   ..|:...|| |:..
Zfish   419 RPSVLRGDHLLLTKSEEVTFSNVTKY---------KGYVHRVELDQVK---LGLSKRFLK-DVYI 470

  Fly  1108 EKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKP--TQTVNEVSLP-------KQP 1163
            :|:|...:.|...:...|:.....::..|.|:.      :|.|  ::::|.||.|       |..
Zfish   471 DKMKFRVEFTVNRIPVRLQHRAVHMAVQHNLKD------VLFPMASRSLNPVSPPALRLFDRKLE 529

  Fly  1164 FTFKG----CHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAK 1224
            :.|:.    |        |||..|       .:|:..|:.|||||||:..|.|...|     ..|
Zfish   530 YNFQQYSAVC--------NIVAGT-------SKPAPYLVFGPPGTGKTVTIVEAIKQ-----VEK 574

  Fly  1225 TL-DRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKE 1288
            .: |..||.||.||:|.|.:.                       ||:       ....|.:..|.
Zfish   575 NIPDAYILACAPSNSAADQLC-----------------------EKL-------ITSEHVDAHKI 609

  Fly  1289 QKLQRVSKENAEILK--KQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQ 1351
            .:|...|:...:|.|  |.:.::.:|:.....|.:|.|..:|
Zfish   610 YRLYASSRNQKDIPKILKDNCNVDEEMIDFPCKEDLMSYKIL----------------------- 651

  Fly  1352 REEFEISHMC--VTRANIICTTLSSCVKLANYVDFFDICIVDEATQCTEPWTLLPMRFGLTH--- 1411
                    :|  ||...::....|.        |.|....||||....|..|::.:. ||.:
Zfish   652 --------ICTLVTAGRLVTGGFSE--------DHFTHNFVDEAGHAVESETIISVA-GLLNAEK 699

  Fly  1412 --MVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMH 1474
              :||.||.:||..::.|..||:.||..|:.:|:.  .|..|.|.|.....:..:.||...||.|
Zfish   700 GQLVLAGDPKQLGPILRSPLAINHGLDVSLLERLM--TQNDLYKRGDVEFDNRYVSKLIMNYRSH 762

  Fly  1475 PEICRWPNQYFYEDQLINAECTARFAS--------------PLIPYCVINLKYTCDSNGAQNKSI 1525
            |.|...||:.||:.:|  ..|....:|              |:|.:.|...    |...:.:.|.
Zfish   763 PYILEVPNRLFYDGEL--KACADEISSNQYCMWEHLPSKGFPVIFHGVPGK----DERESNSPSF 821

  Fly  1526 SNNEEARFVAKLLTEMDKHMPSKRFS------YGLISPYQNQCYALSQVIPSHM---------NI 1575
            .|..|...:...|.::....|.|..|      .|:|:||:.|...:.:.|.:..         |:
Zfish   822 FNIYEINILVDYLKKLLLTQPKKGISRIFPKDIGIIAPYRKQVEKIKRAIDADKDFQDYMGIDNL 886

  Fly  1576 TPQTVDSYQGLEKDVIIISNAR----------TRGCGFLTNYQRLNVALTRPRRCLVICGNFEDL 1630
            ...:|:.:||.|:.||::|..|          |...|||.|.:|.|||:||.:..|::.||...|
Zfish   887 KVGSVEEFQGQERKVIMVSTVRSSVKYISLDETFNIGFLKNEKRFNVAVTRAKSLLIMVGNPMIL 951

  Fly  1631 KSVEMWRNLLDDARKRKVYFNLDRDDVNDLD 1661
            ::.|.|...:|...:|..|..:....|..:|
Zfish   952 RTDESWGRFIDFCLERGGYTGISITSVERID 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	60/266 (23%)
		AAA_19	1194..1251	CDD:289986	21/57 (37%)
		YtxH	<1293..1347	CDD:295162	9/55 (16%)
		AAA_12	1435..1626	CDD:289832	59/229 (26%)
mov10b.2	NP_001037805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..130
		MYCBPAP	<189..>262	CDD:291319
		AAA_11	552..718	CDD:289831	55/240 (23%)
		P-loop_NTPase	552..>714	CDD:304359	55/236 (23%)
		DNA2	<642..983	CDD:224037	97/389 (25%)
		DEAG box	677..680		2/2 (100%)
		AAA_12	725..948	CDD:289832	60/230 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810