DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7504 and ZGRF1

DIOPT Version :9

Sequence 1:NP_001137907.1 Gene:CG7504 / 38904 FlyBaseID:FBgn0035842 Length:1676 Species:Drosophila melanogaster
Sequence 2:NP_060862.3 Gene:ZGRF1 / 55345 HGNCID:25654 Length:2104 Species:Homo sapiens


Alignment Length:1931 Identity:394/1931 - (20%)
Similarity:679/1931 - (35%) Gaps:658/1931 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 IVSEKGVEVESLNPLNGLF-------------INGGKLGD---------KINR--------LAVA 84
            ::||..::.||||.::...             :|..:..|         ||::        :.|.
Human   502 MISESKMDNESLNSIHESLSNVTQPFLEVTFNLNNFETSDTEEESQESNKISQDSESWVKDILVN 566

  Fly    85 EG-STISLGVTGVNLNEITGIHAIFILKKKE------PVVEEIVLSSDDDDTTPLPAVRCP---- 138
            :| |.........|..||.|.|..|:....:      ||.|            .||:..|.    
Human   567 DGNSCFQKRSENTNCEEIEGEHLPFLTSVSDKPTVTFPVKE------------TLPSQFCDKTYV 619

  Fly   139 -----------TGTQPTEFNLKQQIPNF-----------GGKQD---PGQEEEV-----LPSSS- 172
                       ||.:..|::  ..:.||           ..|:|   |.||..:     ||.:. 
Human   620 GFDMGICKTENTGKEIEEYS--DTLSNFESFKWTDAVYGDNKEDANKPIQEVRINYDFALPPNKS 682

  Fly   173 -----NLHLPKLTEVKQEIVKHTSEEIQNIFGE---PSDAILNSVLELNPYLYNKLTNKTANN-E 228
                 |||:|   .::.:|.:::     |:|.|   |...||.|.|:.|.......|:.:.|: :
Human   683 KGINMNLHIP---HIQNQIAENS-----NLFSEDAQPQPFILGSDLDKNDEHVLPSTSSSDNSVQ 739

  Fly   229 ITRKKIHDGDCIELDTDTDRRSISEAQKAEDPSAEREVDDEEEYDESFAMSQAVIREMKAEMHVS 293
            :.....:..:||.||......|.|...    |..::.:..::                 .|.|:|
Human   740 LLNTNQNHYECIALDKSNTHISNSLFY----PLGKKHLISKD-----------------TEAHIS 783

  Fly   294 DGEEDFLLTNGMGNLPEGSPSN----QAYDDIVYVSDSDDDE---LYDKVADWSKLLSQKVVPDV 351
            :.|:       :|.:....|.:    .|.:...|.:..:..|   |.:.::....|.......|.
Human   784 EPED-------LGKIRSPPPDHVEVETAREGKQYWNPRNSSELSGLVNTISILKSLCEHSTALDS 841

  Fly   352 IEM------------SQTYPLENE------------------HKDSDSDL---DIGAKKPKRTLR 383
            :|:            .|||..::.                  ||||...|   ::...:|.::::
Human   842 LEILKKKNTVFQQGTQQTYEPDSPPEVRKPFITVVSPKSPHLHKDSQQILKEDEVELSEPLQSVQ 906

  Fly   384 ISSS-SDEDSA-DEVIVHQTKQK----------GRRSKSKSPNDHVVRQ----------ADST-- 424
            .||| |.|::| ..||..|.::|          |.:.|..:.:..:||.          .|||  
Human   907 FSSSGSKEETAFQAVIPKQIERKTCDPKPVEFQGHQVKGSATSGVMVRGHSSQLGCSQFPDSTEY 971

  Fly   425 ------TPDLPAV-RKLSVSSIDSVYENKQT-------KLNSKLKSCLKSPTKTSVD-------- 467
                  ||:||:. .::....:.|..||..|       .|||:.:..:...::||:.        
Human   972 ENFMTETPELPSTCMQIDFLQVTSPEENISTLSPVSTFSLNSRDEDFMVEFSETSLKARTLPDDL 1036

  Fly   468 ---NMENMTETKSCSNR--QREQIVASRNEPTNICPQ------------KIETN----------- 504
               |:|.|.:::|..|.  ||..:::....|....|:            .|.:|           
Human  1037 HFLNLEGMKKSRSLENENLQRLSLLSRTQVPLITLPRTDGPPDLDSHSYMINSNTYESSGSPMLN 1101

  Fly   505 ---KTSTRKRFVSTTSRDE--LSTTSKEIK--DAPKNNVEPPKKMLRSRSKS-CYIDRPVELDEH 561
               |::.....:....::|  .|..|:|:.  |...||:....|.|:.::.| |.:..|..:|:.
Human  1102 LCEKSAVLSFSIEPEDQNETFFSEESREVNPGDVSLNNISTQSKWLKYQNTSQCNVATPNRVDKR 1166

  Fly   562 ITKN-----------EVPLKKKYESVDNSKEELIVTLEAPAMLTTPTKSKTQCVKKKATQTRGRR 615
            ||..           ....:::.::|:.|..:.:               ..|.:|....|   :|
Human  1167 ITDGFFAEAVSGMHFRDTSERQSDAVNESSLDSV---------------HLQMIKGMLYQ---QR 1213

  Fly   616 KTIHSRDEIRSLTAEAEENKKISP--AKQTN--EEIPIPTKSPLKRNARLLNRSKSCY------M 670
            :...|:|.:        ..||:..  .|||:  |||    |:.|        ...:||      :
Human  1214 QDFSSQDSV--------SRKKVLSLNLKQTSKTEEI----KNVL--------GGSTCYNYSVKDL 1258

  Fly   671 DRLVISETEDPAKKVIKDISPTKSDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGK--------- 726
            ..:..||...|:.:.||..             ::..||...|:|.::|:..|....         
Human  1259 QEISGSELCFPSGQKIKSA-------------YLPQRQIHIPAVFQSPAHYKQTFTSCLIEHLNI 1310

  Fly   727 -LRGVSAEVKVKDKVLDRQRFIDYQAEMNAKWKQKPKDKKKEDEKLKECRREALKKLSEKPKENS 790
             |.|::..::   |.|.:       .:::.....|.:..|..:..:..|......||....||..
Human  1311 LLFGLAQNLQ---KALSK-------VDISFYTSLKGEKLKNAENNVPSCHHSQPAKLVMVKKEGP 1365

  Fly   791 HRSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGP--------------APKLAKTDNAKPPPKKPV 841
            ::                     |.|....|||              .|..:..:.|:|   ..|
Human  1366 NK---------------------GRLFYTCDGPKADRCKFFKWLEDVTPGYSTQEGARP---GMV 1406

  Fly   842 PKQPPAIETF--SQQLQAADKAVLHPQPQCSRPVERKEAELARNQ-RTCNKVTFAEMELYHQKAE 903
            .....:|..:  ||::...::..|         :.||..:..|.| ....|.|....|.|:   |
Human  1407 LSDIKSIGLYLRSQKIPLYEECQL---------LVRKGFDFQRKQYGKLKKFTTVNPEFYN---E 1459

  Fly   904 DSKKLQKKLRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRREN------- 961
            ...||..||                         .|||    |.|:|.:...|:..:.       
Human  1460 PKTKLYLKL-------------------------SRKE----RSSAYSKNDLWVVSKTLDFELDT 1495

  Fly   962 ----------KPVNDIRQHSRSILKWANQWLKHGSVDAVAEQDVLMPIPPEFDSFKNYREIF--- 1013
                      ..:|:|     .||.....:..:...:.|....::.....|..:.||.::.|   
Human  1496 FIACSAFFGPSSINEI-----EILPLKGYFPSNWPTNMVVHALLVCNASTELTTLKNIQDYFNPA 1555

  Fly  1014 -VPLMKLELLS---TIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCG 1074
             :||.:..|.:   ||..:.:::.:.....:..||.|                 ||.|.:|    
Human  1556 TLPLTQYLLTTSSPTIVSNKRVSKRKFIPPAFTNVST-----------------KFELLSL---- 1599

  Fly  1075 MLKETFANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLR 1139
                                ..|.::..:.|...|| |..|.||       .:::..:.|.|   
Human  1600 --------------------GATLKLASELIQVHKL-NKDQATA-------LIQIAQMMASH--- 1633

  Fly  1140 SSPLCRRILKPTQTVNEVSLPKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGT 1204
                        :::.||                   :.:..||:         .:|:|.|..|.
Human  1634 ------------ESIEEV-------------------KELQTHTF---------PITIIHGVFGA 1658

  Fly  1205 GKSRVISELCL---QTLYGNAAKTLDR----KILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLL 1262
            |||.:::.:.|   |....:.|.|:..    |:||.:.:|.|||.:  |||  |..:..:.|  :
Human  1659 GKSYLLAVVILFFVQLFEKSEAPTIGNARPWKLLISSSTNVAVDRV--LLG--LLSLGFENF--I 1717

  Fly  1263 RFGMHEKMSHYSRPFSLEAHFNKAKEQ--KLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTST 1325
            |.|...|::....|:||.|......||  :|..:.||:....::.:  ::..|:|.|..||.|  
Human  1718 RVGSVRKIAKPILPYSLHAGSENESEQLKELHALMKEDLTPTERVY--VRKSIEQHKLGTNRT-- 1778

  Fly  1326 YLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSC-------VKLANYVD 1383
             ||:|::                                  ::..|.::|       :|      
Human  1779 -LLKQVR----------------------------------VVGVTCAACPFPCMNDLK------ 1802

  Fly  1384 FFDICIVDEATQCTEPWTLLPM-RFGLTHMVLVGDMQQLPAVVL-SKKAIDFGLSNSMFDRIQRS 1446
             |.:.::||.:|.|||.:|||: ||....::||||.:|||..:. |..|.:.||..::|||:   
Human  1803 -FPVVVLDECSQITEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFDRL--- 1863

  Fly  1447 LQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLINAECTARFASPLIPY----C 1507
                       .||..|...|.||||.||.|....|..||:..|:|. .|....|||:.:    |
Human  1864 -----------CLMGHKPILLRTQYRCHPAISAIANDLFYKGALMNG-VTEIERSPLLEWLPTLC 1916

  Fly  1508 VINLKYTCDSNGAQ----NKSISNNEEARFVAKLLTEMDKHMPSKRFSYGLISPYQNQCYALSQV 1568
            ..|:|      |.:    :.|..|..||.|..||:..:.....:... .|:|:.|::|.|.|..:
Human  1917 FYNVK------GLEQIERDNSFHNVAEATFTLKLIQSLIASGIAGSM-IGVITLYKSQMYKLCHL 1974

  Fly  1569 I-------PSHMNITPQTVDSYQGLEKDVIIISNARTRGCGFLTNYQRLNVALTRPRRCLVICGN 1626
            :       |....:...|||::||.||::||:|..|||..||:.:.:|:||||||.:|.|:|.||
Human  1975 LSAVDFHHPDIKTVQVSTVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGKRHLLIVGN 2039

  Fly  1627 FEDLKSVEMWRNLLDDARKRK---VYFNLDRDDVNDLDRSLIKKMM 1669
            ...|:..::|..::.....|:   .:.|.....:|.|.:...:|.:
Human  2040 LACLRKNQLWGRVIQHCEGREDGLQHANQYEPQLNHLLKDYFEKQV 2085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7504NP_001137907.1 FHA 4..96 CDD:238017 13/76 (17%)
FHA <10..101 CDD:224630 14/81 (17%)
AAA_11 1171..1428 CDD:289831 68/274 (25%)
AAA_19 1194..1251 CDD:289986 21/63 (33%)
YtxH <1293..1347 CDD:295162 11/53 (21%)
AAA_12 1435..1626 CDD:289832 67/205 (33%)
ZGRF1NP_060862.3 AAA_11 1614..1844 CDD:289831 78/332 (23%)
DNA2 <1739..2057 CDD:224037 110/385 (29%)
AAA_12 1855..2039 CDD:289832 67/205 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2085..2104 0/1 (0%)
DUF2439 4..73 CDD:287368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..359
zf-GRF 1347..1391 CDD:284302 10/64 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D62494at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10887
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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