Protein Alignment CG7504 and MOV10L1

DIOPT Version :9

• Sequence 1: NP_001137907.1
• Gene: CG7504 / 38904
• FlyBaseID: FBgn0035842
• Length: 1676
• Species: Drosophila melanogaster
• Sequence 2: XP_011528998.1
• Gene: MOV10L1 / 54456
• HGNCID: 7201
• Length: 1256
• Species: Homo sapiens
• Alignment Length: 1228
• Identity: 253/1228 - (20%)
• Similarity: 429/1228 - (34%)
• Gaps: 429/1228 - (34%)

  Fly   643 TNEEIPIPTKSPLKR----NARLLNRSKSCYMDR---LVISETEDPAK-------------KVIK 687
            |.:.:.:|.....:|    ||.::..|:|||:.|   :.:.:..|.|.             |...
Human   205 TLDSLKLPDGYTPRRGDVVNAVVVESSQSCYVWRALCMTLVKRRDAAPVHEATHFYGTILLKNKG 269

  Fly   688 DISPTKSDTTDNVLNFVDVRQTRGPSVI----EAPSLPKN--RGKLRGVSAEVKVKDKVLDRQRF 746
            ||..|:      |.:|..:::.|..:::    ....:|:|  ..||.|.....:.:.::||:.:.
Human   270 DIEVTQ------VTHFGTLKEGRSKTMVIWIENKGDIPQNLVSCKLAGWDKSKQFRFQMLDKDQM 328

  Fly   747 IDYQAEMNAKWKQKPKDKKKEDEKLKECRREALKKLSEKPKENSHRSTTNKRKNPTSVPTVQNTN 811
            ....:.::.     |:.:...||.:...              |||......:.:.:|:...:..:
Human   329 CPVVSFVSV-----PEKENSSDENINSL--------------NSHTKNKTSQMSESSLVNNRGIS 374

  Fly   812 RGGFLTKGVDGPAPK-LAKTDNAKPPPKKPVPKQPPAIETFSQQLQAADKAVLHPQPQCSRPVER 875
            .|....||.:|.... |::....:|.|...|   ||..:||...:             |.
Human   375 PGDCTCKGENGEKDNILSRKQMTEPEPGGLV---PPGGKTFIVVI-------------CD----- 418

  Fly   876 KEAELARNQRTCNK---VTFAE------MELYHQKAEDSKKLQ------KKLRKVHFNDDVKVHC 925
                 .:|...|.:   :.|::      :|:.....|:|....      |||:........|...
Human   419 -----GKNPGRCKELLLLCFSDFLIGRYLEVNVISGEESLIAAREPFSWKKLKSSQALTSAKTTV 478

  Fly   926 IERVKGASSKVQ------------GRKECIK---------------LRLSSYRER---------- 953
            :...:..:|:.|            ..::|::               |.:|:|:|:
Human   479 VVTAQKRNSRRQLPSFLPQYPIPDRLRKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEI 543

  Fly   954 ------REW------IRR-------------ENKPVNDIRQHSRSILK------WANQWLKHGSV 987
                  :|:      :||             |.:|  .:....:.|||      .|.:::.:  |
Human   544 YAEMELKEYNMSGIILRRNGDLLVLEVPGLAEGRP--SLYAGDKLILKTQEYNGHAIEYISY--V 604

  Fly   988 DAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYR 1052
            ..:.|:||.:.|.|||:...|    |.|:       .:|..|             |..|...|:
Human   605 TEIHEEDVTLKINPEFEQAYN----FEPM-------DVEFTY-------------NRTTSRRCH- 644

  Fly  1053 LVTRVNSKPFGKFVLYTLYCCGMLKETFAN--LLELKFVSGNVFDLTFEILKQDISEEKLKNIKQ 1115
                        |.|..:...| :|..|..  :|:...|:|| ::...:......|..| ||.|.
Human   645 ------------FALEHVIHLG-VKVLFPEEIILQSPQVTGN-WNHAQDTKSSGQSTSK-KNRKT 694

  Fly  1116 LTARPVVDSLRVELGALSAVHQLRSSPLCRRILKP-----TQTVNEVSLPK-------QPFTFKG 1168
            :|.:           |.....:.|.......:|.|     :..|:|:..||       .|.
Human   695 MTDQ-----------AEHGTEERRVGDKDLPVLAPFTAEMSDWVDEIQTPKARKMEFFNPV---- 744

  Fly  1169 CHKLNEHQENIVLHTYQRIID-DLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILI 1232
               |||:|:..|    :||:. |.:|...::.|||||||:..|.|..||..:.    ..|.:||:
Human   745 ---LNENQKLAV----KRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHFA----LPDSRILV 798

  Fly  1233 CAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKE 1297
            ||.||:|.|                   |:...:||  |...:|.::
Human   799 CAPSNSAAD-------------------LVCLRLHE--SKVLQPATM------------------ 824

  Fly  1298 NAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLTQREEFEISHMCV 1362
                                .:.|.|..:           .:::.:.:.|.....|:.    ...
Human   825 --------------------VRVNATCRF-----------EEIVIDAVKPYCRDGEDI----WKA 854

  Fly  1363 TRANIICTTLSSC-------VKLANYVDFFDICIVDEATQCTEPWTLLPMRFGLT-----HMVLV 1415
            :|..||.||.||.       |::.::...|    ||||.|.:||..|:|:  ||.     .:||.
Human   855 SRFRIIITTCSSSGLFYQIGVRVGHFTHVF----VDEAGQASEPECLIPL--GLMSDISGQIVLA 913

  Fly  1416 GDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKP-----GSYH-LMHTKLFKLSTQYRMH 1474
            ||..||..|:.|:.|:.:||:.|..:|:......|.|:.     |::: |:.|||.|   .||.|
Human   914 GDPMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACGAHNPLLVTKLVK---NYRSH 975

  Fly  1475 PEICRWPNQYFYEDQ------------LINAECTARFASPLIPYCVINLKYTCDSNGAQNKSIS- 1526
            ..:...|::.||..:            |:..|...:...|||.:.|..      |...:.||.|
Human   976 EALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRG------SEAREGKSPSW 1034

  Fly  1527 -NNEEA----RFVAKLLTEMDKHMPSKRFSYGLISPYQNQ-----------CYALSQV-IPSHMN 1574
             |..||    |:...|...:...:.:.  ..|:|:||:.|           .:|..|| ...|::
Human  1035 FNPAEAVQVLRYCCLLAHSISSQVSAS--DIGVITPYRKQWLWSSGGDTGASHAEHQVSFMKHVS 1097

  Fly  1575 I-----------TPQ------------------------TVDSYQGLEKDVIIISNARTRG---- 1600
            :           .||                        :|:.:||.|..|||||..|:..
Human  1098 LWCSHHQAELGKNPQNTEEKVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNEDRFE 1162

  Fly  1601 -----CGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFNLD 1653
                 .|||:|.:|.|||:|||:..|::.||...|.....:..||:.:....||...|
Human  1163 DDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYMGCD 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	65/269 (24%)
		AAA_19	1194..1251	CDD:289986	20/56 (36%)
		YtxH	<1293..1347	CDD:295162	2/53 (4%)
		AAA_12	1435..1626	CDD:289832	65/270 (24%)
MOV10L1	XP_011528998.1	DNA2	426..1217	CDD:224037	203/951 (21%)
		P-loop_NTPase	744..>922	CDD:304359	64/272 (24%)
		AAA_12	933..1194	CDD:289832	66/271 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810