DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7504 and upf1

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_998639.1	Gene:	upf1 / 406783	ZFINID:	ZDB-GENE-040426-2836	Length:	1100	Species:	Danio rerio

Alignment Length:	752	Identity:	201/752 - (26%)
Similarity:	329/752 - (43%)	Gaps:	186/752 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   993 QDVLMPIPPEFDSFKNYREIFVPLMKLEL-------------LSTIERDYKINNKNTFSVSLINV 1044
            |.||:    .::....|:.||.||:|||.             ..|:..|..:|.|.....:|...
Zfish   269 QHVLL----RYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKT 329

  Fly  1045 ETQDM--------CYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELKFVSGNVFDL--TFE 1099
            ::.||        |.|.  :.:..|..|.:.:.:.......:..|  :||:..:|...::  .|:
Zfish   330 DSGDMRLMQGDEICLRY--KGDMAPLWKGIGHVIKVPDNYGDEIA--IELRSSAGAPVEVPHNFQ 390

  Fly  1100 I--LKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKPTQTVNEVSLPKQ 1162
            :  :.:..|.:::::..:..|   ||...|. |.:  .|:|....:...|:|       ..|||:
Zfish   391 VDFVWKSTSFDRMQSALKTFA---VDETSVS-GYI--YHKLLGHEVEDVIIK-------CQLPKR 442

  Fly  1163 PFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTLD 1227
             ||.:|...||..|...|....||       .|:||||||||||:     :...|:..:.|:..:
Zfish   443 -FTAQGLPDLNHSQVYAVKTVLQR-------PLSLIQGPPGTGKT-----VTSATIVYHLARQGN 494

  Fly  1228 RKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQ 1292
            ..:|:||.||.|||.:.            ::.|  :.|:                       |:.
Zfish   495 GPVLVCAPSNIAVDQLT------------EKIH--QTGL-----------------------KVV 522

  Fly  1293 RVSKENAEILKKQ------HNDLKD--------EIQQLKEKTNLTSTYLLQQLQQKEKKLQLISN 1343
            |:..::.|.:...      ||.:::        ::||||::|...|:       ..||:.:.:..
Zfish   523 RLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDETGELSS-------SDEKRYRALKR 580

  Fly  1344 QLSPPLTQREEFEISHMCVTRANIICTTLSSCV-----KLANYVDFFDICIVDEATQCTEPWTLL 1403
                 ..:||       .:..|::||.|   ||     :||. :.|..| ::||:||.|||..::
Zfish   581 -----TAERE-------LLMNADVICCT---CVGAGDPRLAK-MQFRSI-LIDESTQATEPECMV 628

  Fly  1404 PMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLS 1468
            |:..|...::||||..||..||:.|||...|||.|:|:|:.              ::..:..:|.
Zfish   629 PVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLV--------------VLGIRPIRLQ 679

  Fly  1469 TQYRMHPEICRWPNQYFYEDQLINAECTA---------RFASPLIP--YCVINLKYTCDSNGAQN 1522
            .||||||.:..:|:..|||..|.|....|         ::..|..|  :.|...:....|:|.
Zfish   680 VQYRMHPALSAFPSNIFYEGSLQNGVTAADRLKKGFDFQWPQPDKPMFFYVTQGQEEIASSGT-- 742

  Fly  1523 KSISNNEEARFVAKLLTEMDKHMPSKRFSYGLISPYQNQCYALSQVI--------PSHMNITPQT 1579
             |..|..||..|.|:.|.:.| ..:|....|:|:||:.|...|.|.:        ..:..:...:
Zfish   743 -SYLNRTEAANVEKITTRLLK-AGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIAS 805

  Fly  1580 VDSYQGLEKDVIIISNART---RGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLD 1641
            ||::||.|||.||:|..|.   :|.|||.:.:||||||||.|..::|.||.:.|....:|.:||:
Zfish   806 VDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLN 870

  Fly  1642 DARKRKVYFNLDRDDVNDLDRSLIK----KMMVNTIN 1674
            ..:::||   |....:|:|..||::    :.:|||||
Zfish   871 YYKEQKV---LVEGPLNNLRESLMQFSKPRKLVNTIN 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	71/275 (26%)
		AAA_19	1194..1251	CDD:289986	21/56 (38%)
		YtxH	<1293..1347	CDD:295162	12/67 (18%)
		AAA_12	1435..1626	CDD:289832	65/212 (31%)
upf1	NP_998639.1	UPF1_Zn_bind	100..251	CDD:286500
		DNA2	124..889	CDD:224037	194/735 (26%)
		AAA_19	457..>514	CDD:289986	24/80 (30%)
		AAA_12	660..857	CDD:289832	67/214 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820