DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and armi

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_001014556.1	Gene:	armi / 38427	FlyBaseID:	FBgn0041164	Length:	1188	Species:	Drosophila melanogaster

Alignment Length:	1559	Identity:	312/1559 - (20%)
Similarity:	517/1559 - (33%)	Gaps:	550/1559 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 DPSAERE-----VDDEEEYDESFAMSQAVIREMKAEMHVSDGEEDFLLTNGMGNLPEG------- 311
            :|...||     :|.|..:.:...|.:.:.:::||..:..:|    :|:|.:..|..|
  Fly    11 NPDRNREDILESLDRENSFLDQKLMEEKMDQQLKANPNEING----VLSNKIAELTHGLSEMDVS 71

  Fly   312 -SPSNQAYDDIVYVSDSDDDELYDKVADWSKLLSQKVVPDVIEMSQTYPLENEHKDSDSDLDIGA 375
             ..|..|...::...|.|..     |.|...|...||..|:|                .||.:|.
  Fly    72 KESSCTARKGVITSLDGDRG-----VIDKDVLFETKVAEDII----------------LDLHVGC 115

  Fly   376 KKPKRTLRISSSSDEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPDLPAVRKLSVSSID 440
                             ..|.:...|.:..|..|.||..:|  ...|::..::.       .::|
  Fly   116 -----------------VVEYLTFTTGEAMRVVKVKSILEH--SWEDTSQKEIE-------KAVD 154

  Fly   441 SVYENKQTKLNSKLKSCLKSPTKTSVDNMENMTE----TKSCSNRQREQIVASRNEPTNICPQKI 501
            ::...|.|..|::.:|.|...::....:::..||    |....|.:...|      |||....::
  Fly   155 NLKNEKPTFFNTETRSVLGLISQRLASSIDVETEYGQLTVELDNIEMNFI------PTNGDRVRL 213

  Fly   502 ETNKTSTRKRFVSTTSRDELSTTSK----EIKDAPKNNVE----------PPKKMLRSRSKSCYI 552
            |.| ......||.  .:.|:...:|    .|::..|..||          |...:|::
  Fly   214 ECN-IQLDDGFVD--KQGEILEVTKLFPTRIQEGEKCIVERVYVHMVVLGPETYILKT------- 268

  Fly   553 DRPVELDEHITKNEVPLKKKYESVDNSKEELIVTLEAPAMLTTPTKSK---TQCVKKKATQTRGR 614
            |.|...|.|:  .::.|....| ...||      ....|:..||.:..   |:..::.:..:.|.
  Fly   269 DLPTGTDLHL--GDIVLADLIE-CQYSK------FTRRAIKITPLEKNFGATKLTQQSSMGSSGS 324

  Fly   615 RKTIHSRDEIRSLTAEAEENKKISPAKQTNEEIPIPTKSPLKRNARL-----LNRSKSCYMDRLV 674
            .|.:......|.:|||..:.:.:| .|.||.         |.|..||     .|.|:|   ...|
  Fly   325 GKAVTVTGVNRFITAELWQKESVS-LKLTNN---------LNRTLRLESITVCNDSES---QLSV 376

  Fly   675 ISETEDPAKKVIKDISPTKSDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLRGVSAEV--KVK 737
            :|..|.      |:|| :.|:.|   :.|....|..| ..||...|..:..|:|.|...:  |.|
  Fly   377 VSPLES------KEIS-SGSEIT---VTFEIHTQFLG-EAIEKYVLNFDLLKVRRVFTVIVCKTK 430

  Fly   738 DKVLD-RQRFIDYQAEM--------------NAKWKQK----PKDKKKEDEKLKECRREALKKLS 783
            ::|.: .:|.|..:|.|              |..|..|    |      .:::...||....:|.
  Fly   431 EEVAEAEKRMIAAEALMAPGRNSQERSRFYANQVWCNKVDVIP------GQQIVTKRRFVALRLG 489

  Fly   784 --EKPKENSHRSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPKQPP 846
              |.|||......|::|:........|:.:   |||                          :|.
  Fly   490 CFEVPKELRQICLTSERRQEMIKAIEQHYS---FLT--------------------------EPL 525

  Fly   847 AIETFSQQLQAADKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKK 911
            :|:|:..:.    :.:||          .:|.|...|.|..::
  Fly   526 SIKTYMHRF----RLLLH----------LEEIECFVNFRNYDR---------------------- 554

  Fly   912 LRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILK 976
             .:.||..|                   .|.:.|::.:..|||        |...|....|.|..
  Fly   555 -DRAHFLRD-------------------GEFLTLQIENLAERR--------PSLVIGDTLRVINP 591

  Fly   977 WANQWLKHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDY--KINNKNTFSV 1039
            |::                     |:..:.|:|..|...::...:|......:  |.|.::
  Fly   592 WSD---------------------PDSQTTKSYEGIIHKVLFDRILLKFHSSFQEKYNGED---- 631

  Fly  1040 SLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFEILKQD 1104
                       |||....:...|.|.........|::.|.|  |...|........|...:...|
  Fly   632 -----------YRLEFYFSRYSFRKQHHAISKIVGVMGEDF--LFPSKVTKRENPQLDVYMKDDD 683

  Fly  1105 --ISEEKL----KNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKPTQTVNEVSLPKQP 1163
              :.:.||    :::..:..|.|.:.||.|
  Fly   684 MYLYDSKLEWYNQSLNSIQKRAVFNILRGE----------------------------------- 713

  Fly  1164 FTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLYGNAAKTL-D 1227
                        .|||..               ::.||||:||:..:.|..||.:     :.| .
  Fly   714 ------------AENIPY---------------VLFGPPGSGKTMTLIETLLQLV-----RNLPG 746

  Fly  1228 RKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEK-------MSHYSRPFSLEAHFNK 1285
            .:||:...||::.|.:...|.....::..|...|:.:...||       ||:.:.
  Fly   747 ARILVGTPSNSSADLVTKRLIDSKALLQGDFIRLVSYNQVEKDLIPPEIMSYCAT---------- 801

  Fly  1286 AKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLISNQLSPPLT 1350
                                 :|: ..:...::|..:|.:.|..:.|.|
  Fly   802 ---------------------SDV-GAVGSCEDKMMVTESGLKLRCQAK---------------- 828

  Fly  1351 QREEFEISHMCVTRANI-ICTTLSSCVKLANYVDFFDICIVDEATQCTEPWTLLPMRFGLT---- 1410
                |..:|    |..| .||||.:.::|......|...:.|||.|||||.|::|:.. ||
  Fly   829 ----FIGTH----RITISTCTTLGNFLQLGFPAGHFTHVLFDEAGQCTEPETMVPIVM-LTKKRS 884

  Fly  1411 HMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRI------QRSLQTQLDKPGSYHLMHTKLFKLST 1469
            .:||.||.:||.::|.|:.|...|.|.|..:|:      ::.||...:..|...|:.|||.   .
  Fly   885 QVVLSGDPRQLQSIVTSRIASKMGFSISFLERLLERSPYRKDLQRFPESSGYNPLVLTKLL---Y 946

  Fly  1470 QYRMHPEICRWPNQYFYEDQLINAECTARFASPLIPYCVINLKYTCDSNGAQNKSISNNEEARFV 1534
            .||..|.|....::.||:|:||          |::                   |..::.|:|.:
  Fly   947 NYRALPSIMSIYSRLFYDDELI----------PVL-------------------SEKDSRESRLL 982

  Fly  1535 AKL--LTEMDKHMPSKR--FSY-----------------------------------------GL 1554
            :||  :.|.:|.:|...  |.|                                         |:
  Fly   983 SKLRCVFESEKDIPQAHGTFFYGIIGENRQNNDSPSWFNPQEVREVFLMTIALYRANVTADQIGI 1047

  Fly  1555 ISPYQNQCYALSQVIPSHMNITPQ--TVDSYQGLEKDVIIISNARTR----------GCGFLTNY 1607
            |:|||.|...|..:......:.|:  :|:.:||.|:|:|:||..|:.          ..||:...
  Fly  1048 ITPYQKQVKMLRSMFIGTDVVMPKIGSVEEFQGQERDIILISTVRSSEEILRMDARFSLGFVRCS 1112

  Fly  1608 QRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFNLDRDDVNDLDRSLIKKMMVN 1671
            :|||||::|.|..::|.||...|...|.||.|:....|...||..|           :.:|::|
  Fly  1113 KRLNVAVSRARAMMIIFGNPHLLAVDECWRQLILFCVKNNAYFGCD-----------LPQMVIN 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	60/269 (22%)
		AAA_19	1194..1251	CDD:289986	16/57 (28%)
		YtxH	<1293..1347	CDD:295162	6/53 (11%)
		AAA_12	1435..1626	CDD:289832	57/253 (23%)
armi	NP_001014556.1	AAA_11	698..902	CDD:289831	65/327 (20%)
		AAA_19	720..768	CDD:289986	16/52 (31%)
		DNA2	<840..1155	CDD:224037	93/347 (27%)
		UvrD_C_2	909..1132	CDD:304668	58/254 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438953
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840