DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and CG6967

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_611185.3	Gene:	CG6967 / 36922	FlyBaseID:	FBgn0034187	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	169/727 - (23%)
Similarity:	296/727 - (40%)	Gaps:	162/727 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1004 DSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVE-----TQDMCYRLVTRVN--SKP 1061
            |...| .|::..|::.::  .::|..|:..|.||..:.:|.|     ..|... ||.:.:  :.|
  Fly    54 DDLSN-MELYAQLIQSDV--PVQRVSKLTYKITFKSTPVNAEDFVAPNLDQVV-LVPKASLLASP 114

  Fly  1062 FGKFVLYTLY---------------CCGMLKETFANLLELKF-------VSGNVFDLTFEILKQD 1104
            ..|.::..|.               ....:.:..:..:.::|       :||..|   :.|::.
  Fly   115 LPKQLVLALLPHPHEDLEPGDPMLRHVASVDKVSSTTVHVRFSRKHKAVLSGQRF---YAIIRS- 175

  Fly  1105 ISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKP-----TQTVNEVSL----- 1159
                     ::||.|.:..:|.:          |:.|||.||.|.|     ||.|:...:
  Fly   176 ---------RRLTIRYMYRALNL----------LQESPLVRRYLFPFPSWLTQLVDNSQIKVCCD 221

  Fly  1160 ----------PKQPFTFKGCHKLNE--HQENIVLHTYQRIIDDLQPSLT---LIQGPPGTGKSRV 1209
                      |::|.|......||.  :.....|...|||:  ..||..   ::.|||||||:..
  Fly   222 GHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIV--AGPSTQGPYILFGPPGTGKTTT 284

  Fly  1210 ISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHY- 1273
            |.|..||.    ..:....:||:.|.||:|.|.|.                       .|:..|
  Fly   285 IVEAILQL----RLQQPQSRILVTAGSNSACDTIA-----------------------LKLCEYI 322

  Fly  1274 SRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKL 1338
            .....|:.||   .:|||.          :..|..::...:.:.||...:...||.:.....|.:
  Fly   323 ESNIRLQEHF---AQQKLP----------EPDHQLIRVYSRSIYEKGFASVPSLLLKNSNCSKSI 374

  Fly  1339 QLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLA----NYVDFFDICIVDEATQCTEP 1399
            .             :..:.|.  :.:..||..||.:..:|.    ...:||....:|||...|||
  Fly   375 Y-------------DHIKASR--IVKYGIIVATLCTVARLVTDTLGRYNFFTHIFIDEAGASTEP 424

  Fly  1400 WTLLPMRFGL-----THMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHL 1459
            ..|:.: .|:     .|::|.||.:||.||:.|.:|...|||.|:.:|:.:|...:.|:.|:|.
  Fly   425 EALIGI-MGIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSRSLMERLLQSDCYKSDENGNYD- 487

  Fly  1460 MHTKLFKLSTQYRMHPEICRWPNQYFYEDQL------INAECTARFASPLIPYCVINLKYTCD-S 1517
             ..:..:|...||.||:|.|..|:.:|..:|      ::....|.::....|...|..:.|.. :
  Fly   488 -RNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNLAANWSVLTNPQFPIIFQATHGVT 551

  Fly  1518 NGAQNKSIS-NNEEARFVAKLLTEMDKHMPSKRFSYGLISPYQNQCYALSQVIPS--HMNITPQT 1579
            |..||.:.| ||.||..:...:..:.......:...|:::||..|...:::::.|  :.|:...:
  Fly   552 NREQNSTSSYNNLEAEVICWYVKRLINDRVVGQEDVGIVAPYTAQGKLVTKLLQSKGYPNVEVGS 616

  Fly  1580 VDSYQGLEKDVIIISNART-RGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDA 1643
            |::|||.||.:||.|..:: ...||:.|.:|:||.|:|.:..|::.||...|:....::.::::.
  Fly   617 VETYQGREKTIIIASLVKSFTNMGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINEC 681

  Fly  1644 RKRKVYFNLDRD 1655
            :|...|....||
  Fly   682 KKHGTYLLKKRD 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	65/271 (24%)
		AAA_19	1194..1251	CDD:289986	20/59 (34%)
		YtxH	<1293..1347	CDD:295162	6/53 (11%)
		AAA_12	1435..1626	CDD:289832	54/201 (27%)
CG6967	NP_611185.3	AAA_11	251..456	CDD:289831	63/262 (24%)
		AAA_19	256..323	CDD:289986	26/95 (27%)
		UvrD_C_2	464..665	CDD:304668	55/202 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840