DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Aqr

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_001094457.1	Gene:	Aqr / 366163	RGDID:	1306223	Length:	1484	Species:	Rattus norvegicus

Alignment Length:	1523	Identity:	282/1523 - (18%)
Similarity:	528/1523 - (34%)	Gaps:	465/1523 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 DELYDKVADWSKLLSQKVVPDVIEMSQTYPLENEHKDSDSDLDIGAKKPKRTLRISSSSDEDSAD 394
            :|:|:|....|:...:|::  ::|.||.  ||| :...:...::.:|  ...:.|....:|...:
  Rat    47 EEIYEKEIVKSRFAIRKIM--LLEFSQY--LEN-YLWMNYSPEVSSK--AYLMSICCMVNEKFRE 104

  Fly   395 EVIVHQTKQKGRRSKSKSPNDHVVRQADSTTPD-----LPAVRKLSVSSIDSVYE-NKQTKLNSK 453
            .|...:|.:|                    .||     ...:.|.:::..|..:. ::||.|...
  Rat   105 NVPAWETFKK--------------------KPDHFPFFFKRILKAALAETDGEFSLHEQTVLLLF 149

  Fly   454 LKSCLKSPTKTSVDNMENMTETKSCSNRQREQIVA----SRNEPTNICPQKIETNKTSTRKRFVS 514
            |..|..|   ..||.:.:          |.:|:::    ...:|..:   ::|..||...::|.:
  Rat   150 LDHCFNS---LEVDLIRS----------QVQQLISLPMWMGLQPARL---ELELKKTPKLRKFWN 198

  Fly   515 TTSRDELSTTSKEIKDAPKNNVEPPKKMLRSRSKSCYIDRPVELDEHITKNEVPLKKKYESVDNS 579
            ...:::    .|...:|.:...:..:.:.:...|...:.:.:.|.|.:|.::|...:::
  Rat   199 LIKKND----EKMDPEAREQAYQERRFLSQLIQKFISVLKSIPLSEPVTMDKVHYCERF------ 253

  Fly   580 KEELIVTLEAPAMLTTPTKSKTQCVKKKATQTRGRRKTIH-------SRDEIRSLTAEAEENKKI 637
             .||::.|||    ..||:.....:...:      ...:|       .|:|...|.::..:..|.
  Rat   254 -IELMIDLEA----LLPTRRWFNTILDDS------HLLVHCYLSSLVHREEDGHLFSQLLDMLKF 307

  Fly   638 SPAKQTNEEIPIPTKSPLKRNARLLNRSKSCYMDRLV--------------------ISETEDPA 682
            ....:.|::         ..||...|...:.:.||:.                    ::|. |..
  Rat   308 YTGFEINDQ---------TGNALTENEMTTIHYDRITSLQRAAFAHFPELYDFALSNVAEV-DAR 362

  Fly   683 KKVIKDISPTKSDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLRGVSAEVKVKDKVLDRQRFI 747
            ..::|...|..|:|...|.:::.:          .|:||||             :|...|::..:
  Rat   363 DSLVKFFGPLSSNTLHQVASYLCL----------LPTLPKN-------------EDTTFDKEFLL 404

  Fly   748 DY----------QAEMNAKWKQKPKDKKKEDEKLKECRREALKKLSEKPKENSH----------- 791
            :.          |.:...:....|.:|...||.:......:.:.....||.|..
  Rat   405 ELLVSRHERRISQIQQLNQMPLYPTEKIIWDENIVPTEYYSGEGCLALPKLNLQFLTLHDYLLRN 469

  Fly   792 ------RSTTNKRKN-PTSVPTVQ--NTNRGGFLTKG---VDGPAPKLAKTDNAKPPPKKPVPKQ 844
                  .||...|:: ..||..::  .:..||.:..|   :..|.......:.|||...:..|.:
  Rat   470 FNLFRLESTYEIRQDIEDSVSRMKPWQSEYGGVVFGGWARMAQPIVAFTVVEVAKPNIGENWPTR 534

  Fly   845 PPAIETFSQQLQAADKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQ 909
            ..|..|.:  |...|..             :.|.|..|....|..:|....:.|..|.:..:...
  Rat   535 VRADVTIN--LNVRDHI-------------KDEWEGLRKHDVCFLITVRPTKPYGTKFDRRRPFI 584

  Fly   910 KKLRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRS- 973
            :::..|:            |:|.  ::||..:          ::...|....:|..::|..||:
  Rat   585 EQVGLVY------------VRGC--EIQGMLD----------DKGRVIEDGPEPRPNLRGESRTF 625

  Fly   974 -ILKWANQW-------LKHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLEL-----LSTI 1025
             :....||:       :::|:.|.....:|:|...|:.::||...|....||..:.     |..|
  Rat   626 RVFLDPNQYQQDMTNTIQNGAEDVYDTFNVIMRRKPKENNFKAVLETIRNLMNTDCVVPDWLHDI 690

  Fly  1026 ERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELK--F 1088
            ...|...:...:|.....:.|.|                           ..:||.::..||  |
  Rat   691 ILGYGDPSSAHYSKMPNQIATLD---------------------------FNDTFLSIEHLKASF 728

  Fly  1089 VSGNV-------------FDLTFEILK--------QDISEEKLKNIKQLTARPVVDSLRVELGAL 1132
            ...||             |.:||.:..        .|..|:..:..|.|...|.|
  Rat   729 PGHNVKVTVNDPALQIPPFRITFPVRSGKGKKRKDADGEEDDTEEAKTLIVEPHV---------- 783

  Fly  1133 SAVHQLRSSPLCRRILKPTQTVNEVSLPKQPFTFKGCHKLNEHQENIVLHTY---QRIIDDLQPS 1194
                                      :|.     :|.:..|:.:.|.:..|:   :.|...:||.
  Rat   784 --------------------------IPN-----RGPYPYNQPKRNTIQFTHTQIEAIRAGMQPG 817

  Fly  1195 LTLIQGPPGTGKSRVISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQF 1259
            ||::.|||||||:.|..:: :..:|.|..   :::.||..|||.|::.    |...:..::.|:.
  Rat   818 LTMVVGPPGTGKTDVAVQI-ISNIYHNFP---EQRTLIVTHSNQALNQ----LFEKIMALDIDER 874

  Fly  1260 HLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNL-- 1322
            ||||.|..|:.....:.||.....|....:::                :|.:|:::|::...:
  Rat   875 HLLRLGHGEEELETEKDFSRYGRVNYVLARRI----------------ELLEEVKRLQKSLGVPG 923

  Fly  1323 -------TSTY--LLQQLQQKEKKLQLISN--QLSP--------------------PL------- 1349
                   |:.|  |.|.:.:.|:.:..:.|  ..||                    |:
  Rat   924 DASYTCETAGYFFLYQVMSRWEEYMSRVKNTGSASPDAAEVATFFPFHEYFANAPQPIFKGRSYE 988

  Fly  1350 -----------------TQREEFEIS-----------HMCVTRANIICTTLS-SCVKLANYVDF- 1384
                             ||.|||..|           ::.|..|.||..|.: :.:|..:.|..
  Rat   989 EDMEIAEGCFRHIKKIFTQLEEFRASELLRSGLDRSKYLLVKEAKIIAMTCTHAALKRHDLVKLG 1053

  Fly  1385 --FDICIVDEATQCTEPWTLLPMRF--------GLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSM 1439
              :|..:::||.|..|..|.:|:..        .|...:::||..|||.|:.:       ::...
  Rat  1054 FKYDNILMEEAAQILEIETFIPLLLQNPQDGFSRLKRWIMIGDHHQLPPVIKN-------MAFQK 1111

  Fly  1440 FDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYED-------QLINAECTA 1497
            :..:::||.|:..:.|      .....|..|.|....:|...| :.|::       ||:....||
  Rat  1112 YSNMEQSLFTRFVRVG------VPTVDLDAQGRARASLCNLYN-WRYKNLGNLPHVQLLPEFSTA 1169

  Fly  1498 RFASPLIPYCVINLKYTCDSNGAQNKS-----ISNNEEARFVAKLLTEMD-KHMPSKRFSYGLIS 1556
            . |..|..:.:||::   |..|.....     ..|..||.:|..|...|. ...|:.:.|  :::
  Rat  1170 N-AGLLYDFQLINVE---DFQGVGESEPNPYFYQNLGEAEYVVALFMYMCLLGYPADKIS--ILT 1228

  Fly  1557 PYQNQCYALSQVIPSHMNITP--------QTVDSYQGLEKDVIIISNARTRGCGFLTNYQRLNVA 1613
            .|..|.:.:..:|.......|        .|||.:||.:.|.|::|..|||..|.|.:.:||.||
  Rat  1229 TYNGQKHLIRDIINRRCGNNPLIGRPNKVTTVDRFQGQQNDYILLSLVRTRAVGHLRDVRRLVVA 1293

  Fly  1614 LTRPRRCLVICGNFEDLKSVEMWRNLLD 1641
            ::|.|..|.|      ...|.:::|..:
  Rat  1294 MSRARLGLYI------FARVSLFQNCFE 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	74/339 (22%)
		AAA_19	1194..1251	CDD:289986	19/56 (34%)
		YtxH	<1293..1347	CDD:295162	9/66 (14%)
		AAA_12	1435..1626	CDD:289832	53/211 (25%)
Aqr	NP_001094457.1	Aquarius_N	18..802	CDD:293008	155/958 (16%)
		AAA_11	805..1107	CDD:289831	71/332 (21%)
		AAA_19	808..880	CDD:289986	27/79 (34%)
		UvrD_C_2	1115..1304	CDD:304668	53/207 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910