DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and CG2990

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_727386.1	Gene:	CG2990 / 31934	FlyBaseID:	FBgn0030170	Length:	1100	Species:	Drosophila melanogaster

Alignment Length:	1380	Identity:	275/1380 - (19%)
Similarity:	466/1380 - (33%)	Gaps:	479/1380 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 MENMTETKSCSNRQ---REQIVASRNEPTNI--------------CPQKIETNKTSTRK------ 510
            :||.....:.||.|   :||:..|.:|..||              ....|..::....|
  Fly    12 LENDNTDVTSSNPQKKFKEQLDFSSDEVENIDWGDNDDFDLALIAAMDSISNHRLELTKWQRCEV 76

  Fly   511 -RFVSTTSRDELSTTSKEIKDAPKNNVE----PPKKMLRSR-------------SKSCY------ 551
             |.....:|..|....|.|........:    ||...:..:             |..||
  Fly    77 VRLEQLPNRKGLKVHVKRISGGDPETADCQLLPPWNCMPMQVGDTVSLLGKWDPSAGCYVVDKEQ 141

  Fly   552 ---IDRPVELDEHIT-------KNEVPLKKKYESVDNSKEELIVTLEAPAMLTTPTKSKTQCVKK 606
               :..|..|....|       |.:..|::::..:|:....:::......:|....:.|
  Fly   142 GYCVSHPDFLISGTTVTGSLFCKRKSVLQERFRGLDSGNSVMVIGTLVHELLQKVLRQK------ 200

  Fly   607 KATQTRGRRKTIHSRDEIRSLTAEAEENKKISPAKQTNEEIPIPTKSPLKRNARLLNRSKSCYMD 671
                       :..:..|:|...|...:..:                     |.||      |..
  Fly   201 -----------LFDKKHIQSALQEMLASSSL---------------------AHLL------YAS 227

  Fly   672 RLVISETEDPAKKVIKDISPTKSDTTDNVLNFVDVRQTRG--PSVIEAPSLPK-NRGK------- 726
            .|:..|.||...|.|           |.:::|| .:..:|  |||:    ||: .||:
  Fly   228 NLIQVEMEDHLMKFI-----------DPIVSFV-AQYVKGEPPSVL----LPEVYRGQIHEICDI 276

  Fly   727 ----------LRG-VSAEVKVKDKVLDRQRFIDYQAEM-NAKWKQKPKDKKKEDEKLKECR-REA 778
                      |:| |...||||:: ..|:..|..:.:. .|.:..:.|.:....:.:...: |:.
  Fly   277 EENLWVPQLGLKGKVDVSVKVKNQ-RQREEIIPLELKTGRASFSMEHKGQLLLYQLMHSAQGRDT 340

  Fly   779 LKKLSEKPKENSHRSTTNKRKNPTSVPTVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPK 843
            ...|....||...|...:.|.....:..::| :...:||:.|..||        :|..|.:.:|.
  Fly   341 QSGLLLYLKEGLLREVASGRNEQRDLLMLRN-DLAYWLTREVAIPA--------SKEDPLEQLPL 396

  Fly   844 QPPA--------------IETFSQQ---LQAADKAVLHP----QPQCSRPVERKEAELARNQRTC 887
            ..|.              ..:|:|:   ||.:|.   ||    .||....:  .||:.|..|..|
  Fly   397 PEPVYHHSACGNCAYNTICSSFAQKDSSLQLSDS---HPLKKLMPQLLEHL--SEADHAYVQHWC 456

  Fly   888 NKVTFAEMELYHQKAEDSKKLQKKLRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSYRE 952
            ..:...|.  :::::...:....|.......:.:.:..::.|||        :|.| |....||:
  Fly   457 GLLALEEQ--HNRQSSHVRSFWTKDPAEREKEGIAIRHLKLVKG--------QEVI-LEEGRYRQ 510

  Fly   953 RREWIRRENKPVNDIRQHSRSILKWANQWLKHGSVD--AVAEQDVLMPIPPEFDSFKNYREIFVP 1015
            ..| :..|..|..|:......:    .:::...|..  |||...:                :.:.
  Fly   511 TLE-LGEEADPSRDLSLSGFDL----GEYVVISSTSRLAVAAGFI----------------VSIE 554

  Fly  1016 LMKLELLSTIERDYKIN-NKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKET 1079
            ..:|:|  .:|||.... ::.||               ::.:.:|:.|..|....|   |||...
  Fly   555 ARRLDL--RLERDLSQRYSEETF---------------IIDKHDSQSFATFNFTNL---GMLLSE 599

  Fly  1080 FANLLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLC 1144
            .....||:.:.         :.|:...:.|:
  Fly   600 GERFQELRDII---------VAKKPPEQHKV---------------------------------- 621

  Fly  1145 RRILKPTQTVNEVSLPKQPFTFKGCH---KLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGK 1206
                          |||...| ||..   .||:.|:|..|...      ...|..||:|.|||||
  Fly   622 --------------LPKIILT-KGAPILLNLNKVQQNAALRAL------TTSSHLLIKGLPGTGK 665

  Fly  1207 SRVISELCLQTLYGNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMS 1271
            ::.:..| ::.|:     .|.:.:||.|.:::|||:::              ..||.||:
  Fly   666 TQTLVAL-VRLLH-----LLGKSVLITAQTHSAVDNLI--------------MRLLPFGL----- 705

  Fly  1272 HYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLK--DEIQQLKEKTNLTSTYLLQQLQQK 1334
                |.......::..:| |:.:|:|.   |.|   |.|  :|:::...:.::.....|
  Fly   706 ----PMMRLGSGSRIHKQ-LEEISEER---LTK---DCKTVEELEKALGQPSIVGVTCL------ 753

  Fly  1335 EKKLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLANYVDFFDICIVDEATQCTEP 1399
                     ....||.||.:                              ||.||||||||..:|
  Fly   754 ---------GCGHPLFQRRQ------------------------------FDYCIVDEATQVLQP 779

  Fly  1400 WTLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKL 1464
            ..|.|: ...:..|||||.:|||.:|.||:|...|...::|.|:.....|.:
  Fly   780 TVLRPL-IHCSKFVLVGDPEQLPPIVRSKEARQRGADETLFQRLDSEKATAV------------- 830

  Fly  1465 FKLSTQYRMHPEICRWPNQYFY----------------EDQLIN--------------------- 1492
              ||.||||:..|.|..|:..|                |.:|:|
  Fly   831 --LSLQYRMNKTITRLANELTYGGDLKCASDEVSGARFEVELLNEAPRWVQRALTTHLEQAVTLI 893

  Fly  1493 --AECTAR-----FASP-LIPYC-VINLKYTCDSNG----AQNKSIS---NNEEARFVAKLLTEM 1541
              .:|..|     :||. |:..| .|...::.|.:.    ...|.:|   |..||..|..||..:
  Fly   894 NTGDCLERCQEFVYASQRLVDTCSSIEQSFSEDKDEIRKLTSKKRVSKYTNYCEAGIVMHLLRYL 958

  Fly  1542 DK--HMPSKRFSYGLISPYQNQCYALSQVIPSHM--NITPQTVDSYQGLEKDVIIISNARTRG-- 1600
            .|  :..|:   .|:|:||:.| ..|.:.:.|.:  ::...|||.:||.:|::||.|.::|.|
  Fly   959 LKSGYEASR---IGVIAPYRAQ-VELFKKLASKLDTDLECNTVDQFQGRDKNLIIYSCSKTGGDF 1019

  Fly  1601 --------CGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNL-----------LDDARKR 1646
                    ...|.:.:||.||:||.:..|::.|:.:.|:....:|.|           |::.|..
  Fly  1020 SDMERSREAEILEDQRRLTVAITRAKNKLILLGDIKCLEQYGPFRQLFKHIPDRCRLKLEEGRME 1084

  Fly  1647 KVYFNLDRDDVNDLD 1661
            ..:..:..|.|..:|
  Fly  1085 FGWQRIQEDLVGLMD 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	64/258 (25%)
		AAA_19	1194..1251	CDD:289986	18/56 (32%)
		YtxH	<1293..1347	CDD:295162	8/55 (15%)
		AAA_12	1435..1626	CDD:289832	60/257 (23%)
CG2990	NP_727386.1	Dna2	99..297	CDD:285859	41/257 (16%)
		Cas4_I-A_I-B_I-C_I-D_II-B	<283..415	CDD:294426	27/141 (19%)
		TIGR00376	480..1069	CDD:273041	172/803 (21%)
		P-loop_NTPase	636..859	CDD:304359	81/325 (25%)
		AAA_12	815..1055	CDD:289832	61/258 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438964
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840