DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Mov10

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_001101181.1	Gene:	Mov10 / 310756	RGDID:	1598327	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	917	Identity:	208/917 - (22%)
Similarity:	334/917 - (36%)	Gaps:	277/917 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   849 ETF--SQQLQAADKAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKK 911
            |||  ::.|.|...:.|..|.:.:.|.:| ...|.||..:.|::...|..
  Rat   230 ETFYIARFLAAVAHSPLAAQLKPTTPFKR-PPRLTRNPVSTNRIEEGERP--------------- 278

  Fly   912 LRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSSY----RERR--------EWIRRENKPV 964
                           :|.||...:       :.|.|.:|    |.|:        ..|....|.|
  Rat   279 ---------------DRAKGYELE-------LSLALGTYYPPIRLRQLLPTLLQGPSIFTSPKEV 321

  Fly   965 NDIRQHSRSILKWANQWLKHGSV----DAVAEQDV----LMPIPPEFDSF-KNYREIFVPLMKLE 1020
            .:|:....:.||..|..:|...:    :...|.|:    |..:|..:|.. :|.|     |:.||
  Rat   322 AEIKAQLETTLKSRNYEVKLRLLLHLEELQMEHDIRHYDLESVPMTWDPVDQNPR-----LLTLE 381

  Fly  1021 LLSTIE-RDYKINNKNTFSVSLINVETQD-MCYR-LVTRVNSKPFGKFVLYTLYCCGMLKETFAN 1082
            :....| |...:...:.|::....::.:| :.|: .|.:|.              ...:|.:|:.
  Rat   382 VPGVTESRPSVLRGDHLFALLSSEIQQEDPVTYKGFVHKVE--------------LDRVKLSFSP 432

  Fly  1083 LLELKFVSGNVFDLTFEILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRI 1147
            .|..:||.|..|.:.|...:|                    .|||:..||....        |.:
  Rat   433 SLLSRFVDGLTFKVNFTFNRQ--------------------PLRVQHRALELTG--------RWV 469

  Fly  1148 LKPT---QTVNEVSLPKQPFTFKGCHK-LNEHQENIVLHTYQRII-DDLQPSLTLIQGPPGTGKS 1207
            |.||   .....|||......||...: |..:.|.  |...:.|: ...:|:..:|.|||||||:
  Rat   470 LWPTLFPVASRGVSLLPSDVKFKLYDRSLESNPEQ--LQAMKHIVRGTTRPAPYIIFGPPGTGKT 532

  Fly  1208 RVISELCLQTLYGNAAKTLDR-KILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMS 1271
            ..:.|...|.:     |.|.: .||.|..||:..|    ||...|||      ||
  Rat   533 VTLVEAIKQVV-----KHLPKAHILACTPSNSGAD----LLCQRLRV------HL---------- 572

  Fly  1272 HYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEK 1336
                |.|:         .:|...|::    ::....|:|.......:|.        :.:...:|
  Rat   573 ----PSSI---------YRLLAPSRD----IRMVPEDIKTCCNWDPKKG--------EYVYPAKK 612

  Fly  1337 KLQLISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLANY---VDFFDICIVDEATQCTE 1398
            .||                        :..::.|||.:..:|.:.   :|.|....:|||..|.|
  Rat   613 HLQ------------------------QYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCME 653

  Fly  1399 PWTLLPMRFGLT----------HMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDK 1453
            |.:|:.:. ||.          .:||.||.:||..|:.|..|...||..|:.:|:.
  Rat   654 PESLVAIA-GLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERLL--------- 708

  Fly  1454 PGSYHLMHTK---------LFKLSTQYRMHPEICRWPNQYFYEDQL------INAECTARFAS-- 1501
              :|:.::.|         :.||...||.||.|...|||.:|:.:|      ::.|...|:..
  Rat   709 --TYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLP 771

  Fly  1502 ----PLIPYCVINLKYTCDSNGAQNKSISNNEEARFVAKLLTEM-------DKHMPSKRFSYGLI 1555
                |:|.:.|:..    |.....:.|..|.|||..|...|.::       .|...|.| |.|:|
  Rat   772 QQGFPIIFHGVMGK----DEREGNSPSFFNPEEAATVTSYLRQLLAPSSKKGKARLSPR-SVGVI 831

  Fly  1556 SPYQNQC----YALSQV------IPSHMNITPQTVDSYQGLEKDVIIISNARTR----------G 1600
            |||:.|.    |.::::      :....::...:|:.:||.|:.||:||..|:.          .
  Rat   832 SPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFN 896

  Fly  1601 CGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVY------FNLDRDDVND 1659
            .|||.|.:|.|||:||.:..|::.||...|.....|:..|:..::...|      ..||.....|
  Rat   897 LGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQGQD 961

  Fly  1660 LDRSLIK 1666
            |.:.|.|
  Rat   962 LLQGLSK 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	62/272 (23%)
		AAA_19	1194..1251	CDD:289986	20/57 (35%)
		YtxH	<1293..1347	CDD:295162	7/53 (13%)
		AAA_12	1435..1626	CDD:289832	61/238 (26%)
Mov10	NP_001101181.1	DEXXQc_Helz-like	499..734	CDD:350796	71/322 (22%)
Mov10	NP_001101181.1	SF1_C_Upf1	735..940	CDD:350195	57/209 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810