DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7504 and Slc4a1ap

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	XP_038967837.1	Gene:	Slc4a1ap / 298805	RGDID:	1307080	Length:	738	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	141/734 - (19%)
Similarity:	246/734 - (33%)	Gaps:	242/734 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GARLILHNGTNLMGRHSRCRIILGGQYQFVSREHANIIVSEKGVE-------------VESLNPL 64
            |.|.:......|.||.:.|.|.|  ::..|||.||  ::..:|.:             :..|...
  Rat   125 GTRTLKDTSYCLFGRLASCDICL--EHPSVSRYHA--VLQHRGSDPSGDSEDQGQGFYLYDLGST 185

  Fly    65 NGLFINGGKLGDKINRLAVAEGSTISLGVTGVNLNEITGIHAIFILKKKEPVVEEIVLSSDDDDT 129
            :|.|:|..::..: ....|..|..|..|          |...:|||:..|         .|.:..
  Rat   186 HGTFLNKTRIPPR-TYCRVHVGHVIRFG----------GSTRLFILQGPE---------EDREAE 230

  Fly   130 TPLPAVRCPTGTQPTEFNLKQQI----PNFGGKQDPGQEEEVLPSSSNLHLPKLTEVKQEIVKHT 190
            :.|      |.||..|...:||.    ...|  :|..:|:|...::..              ::|
  Rat   231 SEL------TVTQLKELRKQQQALLEKKMLG--EDSDEEDEADTTAGK--------------RNT 273

  Fly   191 S---EEIQNIFGEPSDAILNSVLELNPYLYNKLTNKTANNEITRKKIHDGDCIELDTDTDRRS-- 250
            |   ||:...:|...||:.:.. |.||                         |.|:...||.:
  Rat   274 SGQDEEMGCTWGMGEDAVEDEA-EENP-------------------------IALEFQQDREAFY 312

  Fly   251 ISEAQKAEDPSAEREVDD-EEEYDE-------------------SFAMSQAVIREMKAEMHVSDG 295
            |.:.:||.....:||.:: |.|:||                   ...:::|:....|.|..:...
  Rat   313 IKDPKKALQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMIQCS 377

  Fly   296 EEDFLLTNGMGNLPEGSPSNQA-----YDDIVYVSDSDDDELYDK--VADWSKLLSQKVVPDVIE 353
            .|...:.:.:|.|.:.:.|.:.     .|:..|  |||||...|:  :.:..:|...|....:.|
  Rat   378 LEACRILDTLGLLRQEAVSRKRKAKNWEDEDFY--DSDDDTFLDRTGLVEKKRLNRMKKAGKIDE 440

  Fly   354 MSQTY-PLENEHKDSDSDLDIGAKKPKRTLRI-SSSSDEDSADEVIVHQTKQKGRRSKSKSPNDH 416
            ..:|: .|..:..|::.:|...:::.|.:.:: |.||.:||.|..:        ...||.|..|.
  Rat   441 KPETFESLVAKLNDAERELSEISERLKASSKVQSESSSQDSLDAFM--------SEMKSGSTLDG 497

  Fly   417 VVRQ-------------------ADSTTP-DLPAVRKLSVSSIDSVYENKQTKLNSKLKSCLKSP 461
            |.|:                   .....| ::|.::|..:.:.::  |||..||...|...:|..
  Rat   498 VSRKKLHLRTFELRKEQQRLKGLIKLVKPAEIPELKKTELQTTNA--ENKTKKLALPLFGAMKGG 560

  Fly   462 TKTSVDNMENMTETKSCSNRQREQIVASRNEPTNICPQKIETNKTSTRKRFVSTTSRDELSTTSK 526
            :|..:                                      ||.|..:.  ...|.||.....
  Rat   561 SKFKL--------------------------------------KTGTVGKL--PPKRPELPPALM 585

  Fly   527 EIKDAPKNNVEPPKKMLRSRSKSCYIDRPVELDEHITKNEVPLKKKYESVDNS--------KEEL 583
            ::||.|:                      ||.:|...:.|...::..|.|::.        :.|.
  Rat   586 QMKDEPE----------------------VEEEEEEEEEEKAKEEHEEGVEDGGVRLSQGPEPEP 628

  Fly   584 IVTLEAPAMLTTPTKSKTQCVKKKATQTRGRRKTIHSRDEIRSLTAEAEENKKISPAKQTNEEIP 648
            ....|.|.....|:.||         :|:...|..|...     :...:|..||.|:::.....|
  Rat   629 EAAGEHPGAPPEPSCSK---------ETKSHEKHSHMEQ-----SKGYQEMGKIMPSREDPSAAP 679

  Fly   649 IPTKSPLKRNARLLNRSKS 667
               ::..|::...|.:.||
  Rat   680 ---ENECKKDRDELKKKKS 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017	22/95 (23%)
		FHA	<10..101	CDD:224630	22/100 (22%)
		AAA_11	1171..1428	CDD:289831
		AAA_19	1194..1251	CDD:289986
		YtxH	<1293..1347	CDD:295162
		AAA_12	1435..1626	CDD:289832
Slc4a1ap	XP_038967837.1	minC	<12..>121	CDD:178806
		FHA	113..221	CDD:238017	25/110 (23%)
		DSRM_Kanadaptin	309..391	CDD:380685	14/81 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910