DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7504 and Helz2

DIOPT Version :9

Sequence 1:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster
Sequence 2:	NP_001292205.1	Gene:	Helz2 / 296474	RGDID:	1306056	Length:	2944	Species:	Rattus norvegicus

Alignment Length:	992	Identity:	209/992 - (21%)
Similarity:	365/992 - (36%)	Gaps:	297/992 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   838 KKPVPKQPPAIETFSQQLQAA----------------DKAVLHPQPQCSRPVERKEAELARNQRT 886
            |.|:|....:.:..:|.:.||                ..|::..|.:.||  :|::|::  :|..
  Rat  2036 KLPLPHLGTSFDPLTQTIDAALWMKLLVLLKEERWPEVAALIQEQDKLSR--QREKAQV--HQSR 2096

  Fly   887 CNKVTFAEMELYHQKAEDSKKLQ--KKLRKVHFNDDVKVHCIERVKGASSKVQGRKECIKLRLSS 949
            |..  |.|: .|...:.|:.::|  ..|::......:::..:         |.|...|::
  Rat  2097 CGH--FIEV-AYELGSGDTLQVQLGSSLQRGFLAPTLQLWTV---------VPGFSLCLE----- 2144

  Fly   950 YRERRE--WIRRENKPVND----IRQHSRSILKWANQWLKHGSVDAVAEQD--VLMPIPPEFDSF 1006
            :.||..  :....::|:.|    :.|:|.   .|..:......:.||||.|  ||..:...:|:.
  Rat  2145 HMERPGDCFSGHVHQPLQDQYLEVSQYSG---VWGPRCALESLMSAVAENDSIVLQDVHIYWDTS 2206

  Fly  1007 KNYREIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKP---------- 1061
            :.           :|..|.:.:.....:...::..      ..|| |..|:...|
  Rat  2207 QE-----------QLQGTFQLEAAFLQEKCINIHF------GCCY-LCIRLEGLPLPLASSLPGP 2253

  Fly  1062 --FGKFV-----LYTLYCCGMLKE-------------------------TFANLLELKFVSGNVF 1094
              .|.|:     .||....|:..:                         .|.:.:.::.|...|.
  Rat  2254 SDLGPFLNIDPNTYTWVAHGLSGDWDHELAGDWDQECVDDRQEVPKQVHFFIHHMTMEKVPEEVL 2318

  Fly  1095 ----DLTFEILKQDI----SEEKLKNIKQLTARPVVDSLRVELGALS--------------AVHQ 1137
                ..|.|:|.:.:    .||.::.:|  .|.|:|.|:.:.|..|.              ..||
  Rat  2319 RPSTRFTVEVLSKQLPDLRKEEAVRGLK--NASPLVISIALGLPILEPHWPIPEPRHQISWPRHQ 2381

  Fly  1138 LR------SSPL--------------------CRRILKPTQTVNEVSLPKQPFTFK-------GC 1169
            :.      |.|.                    |||...|..:..:|  |...|..:       |.
  Rat  2382 ISWPRHPISGPCLPVSGLCLPVSGLCHPIPEPCRRGWPPQHSSRKV--PTSRFLERKNYNIPGGH 2444

  Fly  1170 HKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCL--------QTLYGNAAKTL 1226
            ||||:.|:..|...       ||...|:|||||||||:.|...:..        |...|::....
  Rat  2445 HKLNQSQDKAVRSA-------LQKQFTVIQGPPGTGKTVVGFHIVYWFHRSNQEQMPTGSSPSEE 2502

  Fly  1227 DRK----ILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLR-FGMHEKMSHYSRP-FSLEAHFNK 1285
            ::.    :|.|..||.:||.:.|||     :..:.:...|| :|...:.:.:..| .|..:.|.|
  Rat  2503 EKLGGPCVLYCGPSNKSVDVLGGLL-----LRKKTEMRPLRVYGEQAEATEFPLPGVSNRSLFGK 2562

  Fly  1286 AKE-----QKLQRVSKENAEILKKQHNDLKDEIQ----QLKEKTNLTSTYLL--QQLQQKEKKLQ 1339
            ..:     |.|:.::..:.  :::..|....||:    ||:|....:...||  :::..|.:|.:
  Rat  2563 ISQEGRPNQSLRSITLHHR--IRQAPNPYAAEIRKFDAQLREGKIFSKDDLLVYRRVLGKARKYE 2625

  Fly  1340 LISNQLSPPLTQREEFEISHMCVTRANIICT---TLSSCVKLANYVDFFDICIVDEATQCTEPWT 1401
            |..:.:                     |:||   ..|..:|..|....    ::|||...|||.|
  Rat  2626 LERHSV---------------------ILCTCSCAASGSLKALNVRQI----LIDEAGMATEPET 2665

  Fly  1402 LLPM-RFGLTH-MVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKL 1464
            |:|: .|..|. :||:||.:||..||.:::..:.|:..|:|:|                 .|...
  Rat  2666 LIPLVCFSKTEKVVLLGDHKQLRPVVKNEQLRNLGMDRSLFER-----------------YHRDA 2713

  Fly  1465 FKLSTQYRMHPEICRWPNQYFYEDQLI----------------NAECTARFASPLIPYCVINLKY 1513
            ..|.||||||.:||.:|:..||..:|.                ...|...|.| :..|   ..|.
  Rat  2714 IMLDTQYRMHKDICSFPSMEFYGGKLKTWSDLKRPPSLLGHVGKQSCPVIFGS-VQGY---EQKL 2774

  Fly  1514 TCDSNGAQNKSISNNEEARFVAKLLTE--MDKHMPSKRFSYGLISPYQNQCYALSQVIPSH--MN 1574
            ...:......|.:|.||...|.:::.:  :|:.:..|  ...:::||..|..|:|:.:...  ..
  Rat  2775 LVSTEEGNENSRANPEEVTEVVRIIKQLTLDRTVDPK--DVAVLTPYNAQAAAISRGLMQRGVTG 2837

  Fly  1575 ITPQTVDSYQGLEKDVIIISNART----------------RGCGFLTNYQRLNVALTRPRRCLVI 1623
            :|..::...||.|...:|:|..||                :..||:.:..::|||:||.:..|.|
  Rat  2838 VTVTSITKSQGSEWRYVIVSTVRTCPRSDMDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEGLCI 2902

  Fly  1624 CGNFEDLKSVEMWRNLL 1640
            .|:...|:...:|..||
  Rat  2903 IGDHLLLRCCPLWHRLL 2919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	74/286 (26%)
		AAA_19	1194..1251	CDD:289986	22/68 (32%)
		YtxH	<1293..1347	CDD:295162	11/59 (19%)
		AAA_12	1435..1626	CDD:289832	51/226 (23%)
Helz2	NP_001292205.1	DEAD-like_helicase_N	759..989	CDD:421690
		AAA_12	961..1160	CDD:404073
		RNB	1565..1923	CDD:214935
		DEXXc_HELZ2-C	2446..2721	CDD:350798	82/330 (25%)
		AAA_12	2701..2906	CDD:404073	52/227 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341682
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930